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Description of the Business (Details) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 29, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Description of the Business |  |  |  |
Accumulated deficit |  | $ 419,585,792 | $ 372,896,990 |
Issuance of common stock, net of issuance costs |  | $ 4,157,408 | $ 10,699,317 | $ 17,824,717
Common Stock |  |  |  |
Description of the Business |  |  |  |
Issuance of common stock, net of issuance costs, shares |  | 1,953,854 | 3,092,603 | 5,161,502
Issuance of common stock, net of issuance costs |  | $ 1,954 | $ 3,092 | $ 5,163
Subsequent Event | 2023 Sales Agreement | Common Stock |  |  |  |
Description of the Business |  |  |  |
Issuance of common stock, net of issuance costs, shares | 9,822,930 |  |  |
Weighted average price per share issued | $ 3.01 |  |  |
Issuance of common stock, net of issuance costs | $ 28,700,000 |  |  |

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