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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($) | Dec. 31, 2022 | Dec. 31, 2021
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Deferred income tax assets: |  |
Net operating loss carryforward | $ 82,784,742 | $ 79,788,146
Research and orphan drug credits | 51,184,585 | 47,976,370
Capitalized research costs | 7,125,276 |
Capitalized start-up costs | 726,724 | 920,516
Patent amortization | 58,010 | 73,480
Stock-based compensation | 7,247,715 | 7,102,947
Accrued bonus | 733,235 | 592,260
Operating lease liabilities | 252,777 | 528,340
Other | 210,237 | 209,580
Gross deferred income tax assets | 150,323,301 | 137,191,639
Valuation allowance | (149,972,514) | (136,613,829)
Net deferred income tax assets | 350,787 | 577,810
Deferred tax liabilities: |  |
Operating lease right-of-use assets | (206,704) | (433,727)
Property and equipment | (144,083) | (144,083)
Gross deferred income tax liabilities | (350,787) | (577,810)
Net deferred income tax asset/(liability) |  |

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