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Stockholders Equity (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2022
Weighted-Average Fair Value of Options Granted | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2022 | ​ | 2021 | ​ | 2020
Expected term |  | 6.25 years | ​ | 6.25 years | ​ | 6.25 years
Expected volatility |  | 84.66% | ​ | 84.19% | ​ | 84.40%
Risk-free interest rate |  | 1.90% | ​ | 0.78% | ​ | 1.41%
Expected dividend yield |  | 0% | ​ | 0% | ​ | 0%
Stock-Based Compensation Expense | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  |  | 2022 |  | 2021 |  | 2020
Research and development expense | ​ | ​ | $ | 1,059,591 | ​ | $ | 2,214,848 | ​ | $ | 2,946,952
General and administrative expense | ​ | ​ |  | 2,797,989 | ​ |  | 3,872,438 | ​ |  | 3,954,806
Total stock-based compensation expense | ​ | ​ | $ | 3,857,580 | ​ | $ | 6,087,286 | ​ | $ | 6,901,758
2003 Stock Incentive Plan |
Company's Stock Option Activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ | ​ | ​ | ​ | ​ | WEIGHTED- | ​ | AGGREGATE
​ |  | ​ | ​ | WEIGHTED- | ​ | AVERAGE | ​ | INTRINSIC
​ |  | ​ | ​ | AVERAGE | ​ | REMAINING | ​ | VALUE
​ |  | OUTSTANDING | ​ | EXERCISE | ​ | CONTRACTUAL | ​ | (IN
​ | ​ | OPTIONS |  | PRICE |  | TERM (YEARS) |  | THOUSANDS)
Outstanding as of December 31, 2021 | ​ | 93,465 | ​ | $ | 2.00 |  | 0.3 | ​ | ​ | ​
Options forfeited | ​ | (93,465) | ​ |  | 2.00 | ​ | ​ | ​ | ​ | ​
Outstanding, Vested and Exercisable as of December 31, 2022 | ​ | — | ​ |  | — |  | — | ​ | $ | —
​
2013 Equity Incentive Plan |
Company's Stock Option Activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | WEIGHTED- | ​ | AGGREGATE
​ |  | ​ | ​ | WEIGHTED- | ​ | AVERAGE | ​ | INTRINSIC
​ |  | ​ | ​ | AVERAGE | ​ | REMAINING | ​ | VALUE
​ |  | OUTSTANDING | ​ | EXERCISE | ​ | CONTRACTUAL | ​ | (IN
​ |  | OPTIONS |  | PRICE |  | TERM (YEARS) |  | THOUSANDS)
Outstanding as of December 31, 2021 | ​ | 5,655,457 | ​ | $ | 8.30 | ​ | 6.0 | ​ | ​ | ​
Options granted | ​ | 2,020,800 | ​ | ​ | 1.06 | ​ | ​ | ​ | ​ | ​
Options forfeited | ​ | (901,465) | ​ | ​ | 6.56 | ​ | ​ | ​ | ​ | ​
Outstanding as of December 31, 2022 | ​ | 6,774,792 | ​ | ​ | 6.37 | ​ | 6.1 | ​ | $ | 3,506
Vested or expected to vest as of December 31, 2022 | ​ | 6,585,192 | ​ | ​ | 6.52 | ​ | 6.0 | ​ | ​ | 3,142
Exercisable as of December 31, 2022 | ​ | 4,449,925 | ​ | ​ | 8.72 | ​ | 4.7 | ​ | ​ | 37
​
Summary of RSU Activity | The following is a summary of RSU activity for the 2013 Plan for the year ended December 31, 2022: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ | ​ | Weighted-Average |
​ | ​ | Number of Shares | ​ | Grant Date |
​ | ​ | Underlying RSUs |  | Fair Value |
Unvested at December 31, 2021 | ​ | 345,600 | ​ | $ | 3.70 | ​
Forfeited | ​ | (30,765) | ​ |  | 3.81 | ​
Vested | ​ | (110,050) | ​ |  | 3.45 | ​
Unvested at December 31, 2022 | ​ | 204,785 | ​ |  | 3.81 | ​
Inducement Plan |
Company's Stock Option Activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | WEIGHTED- | ​ | AGGREGATE
​ |  | ​ | ​ | WEIGHTED- | ​ | AVERAGE | ​ | INTRINSIC
​ |  | ​ | ​ | AVERAGE | ​ | REMAINING | ​ | VALUE
​ |  | OUTSTANDING | ​ | EXERCISE | ​ | CONTRACTUAL | ​ | (IN
​ |  | OPTIONS |  | PRICE |  | TERM (YEARS) |  | THOUSANDS)
Outstanding as of December 31, 2021 | ​ | 1,813,600 | ​ | $ | 2.08 | ​ | 9.6 | ​ | ​ | ​
Options granted | ​ | 535,000 | ​ | ​ | 0.98 | ​ | ​ | ​ | ​ | ​
Options forfeited | ​ | (15,075) | ​ | ​ | 3.67 | ​ | ​ | ​ | ​ | ​
Outstanding as of December 31, 2022 | ​ | 2,333,525 | ​ | ​ | 1.82 | ​ | 8.7 | ​ | $ | 2,867
Vested or expected to vest as of December 31, 2022 | ​ | 1,749,325 | ​ | ​ | 1.76 | ​ | 8.8 | ​ | ​ | 2,249
Exercisable as of December 31, 2022 | ​ | 425,104 | ​ | ​ | 2.13 | ​ | 8.5 | ​ | ​ | 402

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