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Description of the Business (Details) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 29, 2023	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Description of the Business
Accumulated deficit		$ 419,585,792	$ 372,896,990
Issuance of common stock, net of issuance costs		$ 4,157,408	$ 10,699,317	$ 17,824,717
Common Stock
Description of the Business
Issuance of common stock, net of issuance costs, shares		1,953,854	3,092,603	5,161,502
Issuance of common stock, net of issuance costs		$ 1,954	$ 3,092	$ 5,163
Subsequent Event | 2023 Sales Agreement | Common Stock
Description of the Business
Issuance of common stock, net of issuance costs, shares	9,822,930
Weighted average price per share issued	$ 3.01
Issuance of common stock, net of issuance costs	$ 28,700,000

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