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Statements of Operations and Comprehensive Loss - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Statements of Operations and Comprehensive Loss      
Revenue from collaboration and license agreements $ 75,000 $ 1,159,767 $ 10,162,935
Costs and expenses:      
Research and development expense 28,390,879 47,491,567 44,929,198
General and administrative expense 19,087,443 17,115,405 16,743,127
Total costs and expenses 47,478,322 64,606,972 61,672,325
Loss from operations (47,403,322) (63,447,205) (51,509,390)
Interest income 714,520 19,768 482,487
Net loss and comprehensive loss $ (46,688,802) $ (63,427,437) $ (51,026,903)
Basic net loss per common share (in dollars per share) $ (0.89) $ (1.23) $ (1.12)
Diluted net loss per common share (in dollars per share) $ (0.89) $ (1.23) $ (1.12)
Basic weighted-average number of common shares outstanding (in shares) 52,531,173 51,453,204 45,721,139
Diluted weighted-average number of common shares outstanding (in shares) 52,531,173 51,453,204 45,721,139