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Stockholders' Equity - Stock-Based Compensation Expense (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Stock-based compensation expense
Total stock-based compensation expense	$ 3,857,580	$ 6,087,286	$ 6,901,758
Research and Development
Stock-based compensation expense
Total stock-based compensation expense	1,059,591	2,214,848	2,946,952
General and Administrative Expense
Stock-based compensation expense
Total stock-based compensation expense	$ 2,797,989	$ 3,872,438	$ 3,954,806

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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