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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($) | Dec. 31, 2023 | Dec. 31, 2022
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Deferred income tax assets: |  |
Net operating loss carryforward | $ 88,746,869 | $ 82,784,742
Research and orphan drug credits | 53,152,849 | 51,184,585
Capitalized research costs | 10,748,355 | 7,125,276
Capitalized start-up costs | 532,931 | 726,724
Patent amortization | 42,541 | 58,010
Stock-based compensation | 7,324,617 | 7,247,715
Accrued bonus | 704,974 | 733,235
Operating lease liabilities | 222,452 | 252,777
Other | 87,097 | 210,237
Gross deferred income tax assets | 161,562,685 | 150,323,301
Valuation allowance | (161,351,398) | (149,972,514)
Net deferred income tax assets | 211,287 | 350,787
Deferred income tax liabilities: |  |
Operating lease right-of-use assets | (211,287) | (206,704)
Property and equipment |  | (144,083)
Gross deferred income tax liabilities | (211,287) | (350,787)
Net deferred income tax asset/(liability) |  |

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