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Stock-based Compensation - Incentive Plans (Details) - USD ($) | 1 Months Ended | 12 Months Ended | 24 Months Ended |
--- | --- | --- | --- | ---
May 31, 2022 | Jan. 31, 2022 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2023 | Jan. 09, 2014
Incentive plans |  |  |  |  |  |  |  |
Intrinsic value of options exercised |  |  | $ 82,300 |  |  |  |  |
2003 Stock Incentive Plan |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Period from date of termination that any vested options shall expire |  |  | 60 days |  |  |  |  |
Expiration period |  |  | 10 years |  |  |  |  |
Intrinsic value of options exercised |  |  |  |  | $ 8,668 |  |  |
Cash proceeds from exercise of stock options |  |  | $ 4,239 |  |  |  |  |
Shares issued from exercise of stock options |  |  |  |  | 3,785 |  | 0 |
2003 Stock Incentive Plan | Upon first anniversary of start date |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Percent of shares subject to option grant that will vest |  |  | 25.00% |  |  |  |  |
2003 Stock Incentive Plan | Each month after the first anniversary |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Percent of shares subject to option grant that will vest |  |  | 2.083% |  |  |  |  |
2013 Equity Incentive Plan |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Period from date of termination that any vested options shall expire |  |  | 90 days |  |  |  |  |
Expiration period |  |  | 10 years |  |  |  |  |
Unrecognized compensation expense related to unvested options |  |  | $ 4,200,069 |  |  |  | $ 4,200,069 |
Period for unrecognized compensation expense related to unvested options yet has not been recognized |  |  | 2 years 8 months 12 days |  |  |  |  |
Cash proceeds from exercise of stock options |  |  | $ 116,497 |  |  |  |  |
Shares issued from exercise of stock options |  |  | 100,960 | 0 | 0 | 0 |  |
Fair value of shares vested |  |  | $ 1,710,938 | $ 3,306,412 | $ 5,936,641 |  |  |
2013 Equity Incentive Plan | Stock options vesting based on performance | Employees |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Maximum fair value of option excluded from the unrecognized compensation expense |  | $ 113,520 |  |  |  |  |  |
Authorized shares |  |  |  |  |  |  |  |
Shares available for future grants |  | 141,900 |  |  |  |  |  |
2013 Equity Incentive Plan | Upon first anniversary of start date |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Percent of shares subject to option grant that will vest |  |  | 25.00% |  |  |  |  |
2013 Equity Incentive Plan | Each month after the first anniversary |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Percent of shares subject to option grant that will vest |  |  | 2.083% |  |  |  |  |
2013 Equity Incentive Plan | Vesting upon FDA Approval | Stock options vesting based on performance | Employees |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Percent of shares subject to option grant that will vest |  | 50.00% |  |  |  |  |  |
2013 Equity Incentive Plan | Vesting upon First Commercial Sale | Stock options vesting based on performance | Employees |  |  |  |  |  |  |  |
Incentive plans |  |  |  |  |  |  |  |
Percent of shares subject to option grant that will vest |  | 50.00% |  |  |  |  |  |
Common Stock | 2013 Equity Incentive Plan |  |  |  |  |  |  |  |
Authorized shares |  |  |  |  |  |  |  |
Common stock authorized |  |  | 11,681,878 |  |  |  | 11,681,878 | 1,000,000
Shares available for future grants |  |  | 2,531,613 |  |  |  | 2,531,613 |
Maximum number of shares that may be issued pursuant to exercise of incentive stock |  |  |  |  |  |  |  | 20,000,000
Increase in number of shares of common stock | 2,619,622 |  |  |  |  |  |  |
Maximum percentage of shares of common stock issued and outstanding on the immediately preceding fiscal year, or such lesser number of shares as determined by the board of directors or the compensation committee |  |  | 4.00% |  |  |  | 4.00% |

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