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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Deferred income tax assets:
Net operating loss carryforward	$ 88,746,869	$ 82,784,742
Research and orphan drug credits	53,152,849	51,184,585
Capitalized research costs	10,748,355	7,125,276
Capitalized start-up costs	532,931	726,724
Patent amortization	42,541	58,010
Stock-based compensation	7,324,617	7,247,715
Accrued bonus	704,974	733,235
Operating lease liabilities	222,452	252,777
Other	87,097	210,237
Gross deferred income tax assets	161,562,685	150,323,301
Valuation allowance	(161,351,398)	(149,972,514)
Net deferred income tax assets	211,287	350,787
Deferred income tax liabilities:
Operating lease right-of-use assets	(211,287)	(206,704)
Property and equipment		(144,083)
Gross deferred income tax liabilities	(211,287)	(350,787)
Net deferred income tax asset/(liability)

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from operating lease liabilities.

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Amount of deferred tax liability attributable to taxable temporary differences from operating lease right-of-use assets.

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