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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2024
Income Taxes |
Schedule of Gross Deferred Tax Asset and Related Valuation Allowance | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2024 |  | 2023 |
Deferred income tax assets: | ​ | ​ | ​ | ​ | ​ | ​ | ​
Net operating loss carryforward | ​ | $ | 96,811,786 | ​ | $ | 88,746,869 | ​
Research and orphan drug credits | ​ |  | 54,937,994 | ​ |  | 53,152,849 | ​
Capitalized research costs | ​ |  | 11,861,613 | ​ |  | 10,748,355 | ​
Capitalized start-up costs | ​ |  | 339,138 | ​ |  | 532,931 | ​
Patent amortization | ​ |  | 27,071 | ​ |  | 42,541 | ​
Stock-based compensation | ​ |  | 6,699,628 | ​ |  | 7,324,617 | ​
Accrued bonus | ​ | ​ | 25,356 | ​ | ​ | 704,974 | ​
Operating lease liabilities | ​ | ​ | 18,394 | ​ | ​ | 222,452 | ​
Other | ​ | ​ | 1,303 | ​ | ​ | 87,097 | ​
Gross deferred income tax assets | ​ |  | 170,722,283 | ​ |  | 161,562,685 | ​
Valuation allowance | ​ |  | (170,722,283) | ​ |  | (161,351,398) | ​
Net deferred income tax assets | ​ |  | — | ​ |  | 211,287 | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Deferred income tax liabilities: | ​ | ​ | ​ | ​ | ​ | ​ | ​
Operating lease right-of-use assets | ​ |  | — | ​ |  | (211,287) | ​
Gross deferred income tax liabilities | ​ |  | — | ​ |  | (211,287) | ​
Net deferred income tax asset/(liability) | ​ | $ | — | ​ | $ | — | ​
Schedule of Reconciliations Between Statutory Federal Income Tax Rate and Effective Income Tax Rate of Income Tax Expense | ​
​ | ​ | ​ | ​ | ​ | ​
​ |  | 2024 |  | 2023 |
U.S. Federal statutory tax rate |  | 21.0 | % | 21.0 | %
State taxes |  | 5.9 |  | 6.3 |
Research credit |  | 0.4 |  | 0.7 |
Orphan drug credit |  | 4.1 |  | 4.1 |
Stock-based compensation | ​ | (5.1) | ​ | 2.3 | ​
Executive compensation | ​ | (1.2) | ​ | (0.1) | ​
Other | ​ | (0.4) | ​ | (3.5) | ​
Change in valuation allowance |  | (24.7) |  | (30.8) |
Provision for income taxes |  | — | % | — | %
​

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-2 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 231 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482663/740-10-55-231 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12A -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12A Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 + Details
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