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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($) | Dec. 31, 2024 | Dec. 31, 2023
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Deferred income tax assets: |  |
Net operating loss carryforward | $ 96,811,786 | $ 88,746,869
Research and orphan drug credits | 54,937,994 | 53,152,849
Capitalized research costs | 11,861,613 | 10,748,355
Capitalized start-up costs | 339,138 | 532,931
Patent amortization | 27,071 | 42,541
Stock-based compensation | 6,699,628 | 7,324,617
Accrued bonus | 25,356 | 704,974
Operating lease liabilities | 18,394 | 222,452
Other | 1,303 | 87,097
Gross deferred income tax assets | 170,722,283 | 161,562,685
Valuation allowance | (170,722,283) | (161,351,398)
Net deferred income tax assets |  | 211,287
Deferred income tax liabilities: |  |
Operating lease right-of-use assets |  | (211,287)
Gross deferred income tax liabilities |  | (211,287)
Net deferred income tax asset/(liability) |  |

X
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