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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($)	Dec. 31, 2024	Dec. 31, 2023
Deferred income tax assets:
Net operating loss carryforward	$ 96,811,786	$ 88,746,869
Research and orphan drug credits	54,937,994	53,152,849
Capitalized research costs	11,861,613	10,748,355
Capitalized start-up costs	339,138	532,931
Patent amortization	27,071	42,541
Stock-based compensation	6,699,628	7,324,617
Accrued bonus	25,356	704,974
Operating lease liabilities	18,394	222,452
Other	1,303	87,097
Gross deferred income tax assets	170,722,283	161,562,685
Valuation allowance	(170,722,283)	(161,351,398)
Net deferred income tax assets		211,287
Deferred income tax liabilities:
Operating lease right-of-use assets		(211,287)
Gross deferred income tax liabilities		(211,287)
Net deferred income tax asset/(liability)

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- Definition

Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from Accrued bonus.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences capitalized research costs.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences capitalized start up costs.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences patent amortization.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences from research and orphan drug credits.

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- Definition

Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from operating lease liabilities.

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No definition available.

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- Definition

Amount of deferred tax liability attributable to taxable temporary differences from operating lease right-of-use assets.

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Amount of deferred tax liability attributable to taxable temporary differences.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.

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Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences, classified as other.

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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

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