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Related Party Transactions - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 26, 2025
Apr. 28, 2025
Mar. 18, 2025
Oct. 11, 2024
Sep. 19, 2024
Oct. 31, 2024
Sep. 30, 2024
Mar. 31, 2027
Mar. 31, 2026
Dec. 31, 2024
Sep. 30, 2025
Dec. 31, 2026
Dec. 31, 2025
Paragon Option Agreements | Paragon Therapeutics                          
Related Party Transaction [Line Items]                          
Accounts payable and other current liabilities                     $ 6,300    
Paragon Option Agreements | Paragon Therapeutics | Forecast                          
Related Party Transaction [Line Items]                          
Percent of outstanding shares               1.00% 1.00%     1.00% 1.00%
CR-001 | Paragon Option Agreements | Paragon Therapeutics | License Agreement Terms                          
Related Party Transaction [Line Items]                          
Non-refundable milestone payments     $ 22,000       $ 22,000            
Milestone payment   $ 2,500                      
CR-002 | Paragon Option Agreements | Paragon Therapeutics | License Agreement Terms                          
Related Party Transaction [Line Items]                          
Development costs incurred                   $ 800      
Accounts payable and other current liabilities                   $ 800      
Non-refundable milestone payments $ 46,000           $ 46,000            
RSAs                          
Related Party Transaction [Line Items]                          
Granted (in shares)           296,104       296,104 20,164    
Consultant Providing Regulatory And Strategic Services | RSAs                          
Related Party Transaction [Line Items]                          
Granted (in shares)           19,740              
Fairmount Convertible Note Purchase Agreement | Convertible Notes Payable                          
Related Party Transaction [Line Items]                          
Convertible notes payable           $ 37,500         $ 0    
Paragon Therapeutics | CR-001 | Paragon Option Agreements | Paragon Therapeutics | License Agreement Terms                          
Related Party Transaction [Line Items]                          
Development costs incurred                   $ 4,700      
Related Party                          
Related Party Transaction [Line Items]                          
Accounts payable and other current liabilities                   $ 7,221 $ 6,273    
Related Party | Paragon Option Agreements | Paragon Therapeutics | Forecast                          
Related Party Transaction [Line Items]                          
Percent of outstanding shares                   1.00%      
Related Party | Paragon Option Agreements | Paragon Therapeutics | License Agreement Terms                          
Related Party Transaction [Line Items]                          
Accounts payable and other current liabilities                   $ 7,200      
Related Party | CR-001 | Paragon Option Agreements | Paragon Therapeutics | License Agreement Terms                          
Related Party Transaction [Line Items]                          
Accounts payable and other current liabilities                   6,200      
Non-refundable milestone payments                   12,000      
Milestone payment                   10,000      
Related Party | CR-002 | Paragon Option Agreements | Paragon Therapeutics | License Agreement Terms                          
Related Party Transaction [Line Items]                          
Non-refundable milestone payments                   26,000      
Milestone payment                   $ 20,000      
Related Party | RSAs | Chief Executive Officer                          
Related Party Transaction [Line Items]                          
Granted (in shares)       197,404                  
Cost paid       $ 200                  
RSAs purchased (in shares)       148,053                  
Related Party | Ordinary Shares                          
Related Party Transaction [Line Items]                          
Granted (in shares)       763,913                  
Related Party | Consultant Providing Regulatory And Strategic Services | RSAs                          
Related Party Transaction [Line Items]                          
Granted (in shares)       19,740                  
Related Party | Fairmount Convertible Note Purchase Agreement | Convertible Notes Payable                          
Related Party Transaction [Line Items]                          
Convertible notes payable           15,000              
Related Party | Crescent Biopharma | Paragon Therapeutics                          
Related Party Transaction [Line Items]                          
Ownership percentage (less than for Paragon and Parascent, and more than for Fairmount) (in percent)                   9.00% 5.00%    
Related Party | Crescent Biopharma | Parascent Holding LLC                          
Related Party Transaction [Line Items]                          
Ownership percentage (less than for Paragon and Parascent, and more than for Fairmount) (in percent)                   9.00% 5.00%    
Related Party | Crescent Biopharma | Fairmount Healthcare Fund II L.P.                          
Related Party Transaction [Line Items]                          
Ownership percentage (less than for Paragon and Parascent, and more than for Fairmount) (in percent)                   74.00% 5.00%    
Related Party | Paragon Therapeutics | Fairmount Healthcare Fund II L.P.                          
Related Party Transaction [Line Items]                          
Ownership percentage (less than for Paragon and Parascent, and more than for Fairmount) (in percent)                     5.00%    
Related Party | Fairmount Healthcare Fund II L.P. | Fairmount Convertible Note Purchase Agreement | Convertible Notes Payable                          
Related Party Transaction [Line Items]                          
Convertible notes payable           $ 15,000              
Related Party | Fairmount Healthcare Fund II L.P. | Series Seed Convertible Preferred Stock                          
Related Party Transaction [Line Items]                          
Convertible preferred stock, issued (in shares)         20,000,000   20,000,000            
Convertible preferred stock, purchase price (in dollars per share)         $ 0.20   $ 0.20            
Issuance of Series Seed convertible preferred stock         $ 4,000   $ 4,000