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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2024 | Dec. 31, 2025
Cash flows from operating activities: |  |  |
Net loss |  | $ (17,867) | $ (153,942)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Share-based compensation expense | [1] | 1,134 | 13,300
Research and development license expense |  | 0 | 80,000
Depreciation expense |  | 0 | 84
Non-cash interest expense | [2] | 2 | 2,185
Non-cash research and development expense related to Paragon option agreement |  | 1,000 | 0
Non-cash lease expense |  | 0 | 212
Changes in operating assets and liabilities |  |  |
Accrued expenses and other current liabilities | [3] | 2,172 | 5,363
Deferred revenue |  | 0 | 4,156
Deposit liability |  | 0 | 5,000
Operating lease liability |  | 0 | (37)
Accounts receivable |  | 0 | (18,000)
Prepaid expenses and other current assets |  | (38) | (5,015)
Other assets |  | 0 | 162
Net cash used in operating activities |  | (6,269) | (71,532)
Cash flows from investing activities: |  |  |
Purchase of research and development license |  | 0 | (72,000)
Purchases of property and equipment |  | 0 | (919)
Net cash used in investing activities |  | 0 | (72,919)
Cash flows from financing activities: |  |  |
Proceeds from the Pre-Closing Financing, net |  | 0 | 143,007
Proceeds from the private placement financing, net |  | 0 | 178,880
Cash acquired in connection with the reverse recapitalization |  | 0 | 1,269
Proceeds from early exercise of options |  | 0 | 5
Proceeds from issuance of common stock |  | 315 | 0
Proceeds from issuance of Series Seed convertible preferred stock |  | 4,000 | 0
Proceeds from the issuance of notes payable, net of issuance costs | [4] | 37,480 | 0
Payment of deferred offering costs |  | (760) | 0
Repurchase of equity awards |  | 0 | (177)
Net cash provided by financing activities |  | 41,035 | 322,984
Net increase in cash, cash equivalents, and restricted cash |  | 34,766 | 178,533
Cash at beginning of period |  | 0 | 34,766
Cash, cash equivalents, and restricted cash at end of period |  | 34,766 | 213,299
Supplemental disclosure of non-cash operating and financing activities: |  |  |
Operating lease liability arising from obtaining operating right-of-use asset |  | 0 | 1,681
Assets acquired in connection with the reverse recapitalization |  | 0 | 1,710
Other liabilities assumed in connection with the reverse recapitalization |  | 0 | (2,454)
Purchases of property and equipment included in accounts payable and accrued expenses |  | 0 | 11
Deferred financing costs included in accounts payable and accrued expenses |  | 53 | 6,945
Convertible note principal and non-cash accrued interest converted to ordinary shares |  | 0 | 40,515
Non-cash exchange of Pre-Merger Crescent Series Seed Preferred Stock for Series A Non-Voting Convertible Preferred Shares |  | 0 | 4,000
Nonrelated Party |  |  |
Changes in operating assets and liabilities |  |  |
Accounts payable |  | 107 | 2,081
Related Party |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Share-based compensation expense |  | 61 | 4,297
Non-cash interest expense |  | 0 | 865
Changes in operating assets and liabilities |  |  |
Accrued expenses and other current liabilities |  | 341 | 0
Related party accounts payable and other current liabilities |  | 7,221 | (7,081)
Cash flows from financing activities: |  |  |
Proceeds from the issuance of notes payable, net of issuance costs |  | $ 14,993 | $ 0
[1] | Includes related party amounts of $4,297 for the twelve months ended December 31, 2025 and $61 for the period from September 19, 2024 (inception) through December 31, 2024.
[2] | Includes related party amounts of $865 for the twelve months ended December 31, 2025 and $0 for the period from September 19, 2024 (inception) through December 31, 2024.
[3] | Includes related party amounts of $0 for the twelve months ended December 31, 2025 and $341 for the period from September 19, 2024 (inception) through December 31, 2024.
[4] | Includes related party amounts of $0 for the twelve months ended December 31, 2025 and $14,993 for the period from September 19, 2024 (inception) through December 31, 2024

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