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v3.22.2.2

Condensed Consolidated Statements of Cash Flows - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Operating activities |  |
Net loss | $ (232,884,000) | $ (241,375,000)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |  |
Depreciation and amortization | 2,649,000 | 2,618,000
Stock-based compensation expense | 39,011,000 | 40,418,000
Write-off of prepaid manufacturing services related to the termination of CHS-2020 | 0 | 3,210,000
Write-downs of inventory | 26,000,000 | 5,192,000
Non-cash interest expense from amortization of debt discount & issuance costs | 5,631,000 | 3,150,000
Upfront and option payments to Junshi Biosciences | 35,000,000 | 136,000,000
Loss on debt extinguishment | 6,222,000 |
Other non-cash adjustments, net | 1,844,000 | 2,708,000
Changes in operating assets and liabilities: |  |
Trade receivables, net | 31,849,000 | 20,722,000
Inventory | (37,556,000) | 2,936,000
Prepaid manufacturing | (6,967,000) | (2,884,000)
Other prepaid, current and non-current assets | (12,509,000) | (4,590,000)
Accounts payable | (6,149,000) | 30,495,000
Accrued rebates, fees and reserves | (25,006,000) | 3,215,000
Accrued compensation | (623,000) | (3,451,000)
Accrued and other current and non-current liabilities | 32,317,000 | 16,526,000
Net cash (used in) provided by operating activities | (141,171,000) | 14,890,000
Investing activities |  |
Purchases of property and equipment | (1,952,000) | (821,000)
Purchases of investments in marketable securities |  | (171,779,000)
Proceeds from maturities of investments in marketable securities |  | 62,700,000
Upfront and option payments to Junshi Biosciences | (35,000,000) | (136,000,000)
Net cash used in investing activities | (36,952,000) | (245,900,000)
Financing activities |  |
Proceeds from 2027 Term Loans, net of debt discount & issuance costs | 240,679,000 |
Proceeds from issuance of common stock to Junshi Biosciences, net of issuance costs |  | 40,903,000
Proceeds from issuance of common stock upon exercise of stock options | 631,000 | 9,726,000
Proceeds from purchase under the employee stock purchase plan | 1,655,000 | 1,985,000
Taxes paid related to net share settlement of RSUs | (3,621,000) | (1,730,000)
Repayment of 2022 Convertible Notes and premiums | (109,000,000) |
Repayment of 2025 Term Loan, premiums and exit fees | (81,750,000) |
Other financing activities | (861,000) | (492,000)
Net cash provided by financing activities | 47,733,000 | 50,392,000
Net decrease in cash, cash equivalents and restricted cash | (130,390,000) | (180,618,000)
Cash, cash equivalents and restricted cash at beginning of period | 417,635,000 | 541,598,000
Cash, cash equivalents and restricted cash at end of period | $ 287,245,000 | $ 360,980,000

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