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Balance Sheet Components | 12 Months Ended
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Dec. 31, 2022
Balance Sheet Components |
Balance Sheet Components | 5.Balance Sheet Components Property and Equipment, Net Property and equipment, net consisted of the following: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31,
(in thousands) | ​ | 2022 | ​ | 2021
Machinery and equipment | ​ | $ | 12,944 | ​ | $ | 11,876
Computer equipment and software | ​ |  | 3,183 | ​ |  | 3,033
Furniture and fixtures | ​ |  | 1,258 | ​ |  | 1,129
Leasehold improvements | ​ |  | 6,198 | ​ |  | 5,942
Finance lease right of use assets | ​ | ​ | 4,632 | ​ | ​ | 2,294
Construction in progress | ​ |  | 696 | ​ |  | 388
Total property and equipment | ​ |  | 28,911 | ​ |  | 24,662
Accumulated depreciation and amortization | ​ |  | (20,157) | ​ |  | (16,849)
Property and equipment, net | ​ | $ | 8,754 | ​ | $ | 7,813
​ Depreciation and amortization expense related to property and equipment, net was $3.6 million, $3.5 million, and $2.9 million in 2022, 2021 and 2020, respectively. There were no material impairments of property and equipment in 2022, 2021 and 2020. As of December 31, 2022 and 2021, the net book value of software implementation costs related to hosting arrangements was $3.5 million and $1.3 million, respectively, and the amortization expense was immaterial for all periods presented. Accrued and Other Current Liabilities Accrued and other current liabilities consisted of the following:
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31,
(in thousands) | ​ | 2022 | ​ | 2021
Accrued commercial and research and development manufacturing | ​ | $ | 21,774 | ​ | $ | 30,541
Accrued co-development costs payable to Junshi Biosciences | ​ | ​ | 8,356 | ​ | ​ | 1,926
Lease liabilities, current | ​ | ​ | 4,318 | ​ | ​ | 3,492
Accrued other | ​ |  | 15,649 | ​ |  | 12,168
Total Accrued and other current liabilities | ​ | $ | 50,097 | ​ | $ | 48,127
​

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- Definition The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -URI https://asc.fasb.org/topic&trid=2122208 + Details
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