Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenue:
Net revenue	$ 211,042	$ 326,551	$ 475,824
Costs and expenses:
Cost of goods sold	70,083	57,591	37,667
Research and development	199,358	363,105	142,759
Selling, general and administrative	198,481	169,713	139,079
Total costs and expenses	467,922	590,409	319,505
(Loss) income from operations	(256,880)	(263,858)	156,319
Interest expense	(32,474)	(22,959)	(21,166)
Loss on debt extinguishment	(6,222)
Other income (expense), net	3,822	(283)	554
(Loss) income before income taxes	(291,754)	(287,100)	135,707
Income tax provision	0	0	3,463
Net (loss) income	$ (291,754)	$ (287,100)	$ 132,244
Net (loss) income per share:
Basic (In dollar per share)	$ (3.76)	$ (3.81)	$ 1.85
Diluted (In dollar per share)	$ (3.76)	$ (3.81)	$ 1.62
Weighted-average number of shares used in computing basic and diluted net (loss) income per share:
Basic (In shares)	77,630,020	75,449,632	71,411,705
Diluted (In shares)	77,630,020	75,449,632	83,491,898

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 924
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 11.L)
-URI https://asc.fasb.org/extlink&oid=6472922&loc=d3e499488-122856

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.2(a),(d))
-URI https://asc.fasb.org/extlink&oid=126953954&loc=SL114868664-224227