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Net (Loss) Income Per Share - Outstanding Dilutive Potential Shares Excluded from Calculation of Diluted Net (loss) Income Per Share (Details) - shares
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Antidilutive securities excluded from computation of EPS      
Antidilutive securities excluded from the calculation of diluted net (loss) income per share 37,635,124 38,122,727 14,002,963
Stock options, including shares subject to ESPP      
Antidilutive securities excluded from computation of EPS      
Antidilutive securities excluded from the calculation of diluted net (loss) income per share 22,214,875 19,895,097 9,521,403
Restricted Stock Units      
Antidilutive securities excluded from computation of EPS      
Antidilutive securities excluded from the calculation of diluted net (loss) income per share 2,399,465 1,811,607 7,689
8.2% Convertible Notes due 2022 | Shares Issuable Upon Conversion of Convertible Notes      
Antidilutive securities excluded from computation of EPS      
Antidilutive securities excluded from the calculation of diluted net (loss) income per share 1,078,632 4,473,871 4,473,871
1.5% Convertible Senior Subordinated Notes due 2026 | Shares Issuable Upon Conversion of Convertible Notes      
Antidilutive securities excluded from computation of EPS      
Antidilutive securities excluded from the calculation of diluted net (loss) income per share 11,942,152 11,942,152