<SEC-DOCUMENT>0001104659-23-099828.txt : 20230912
<SEC-HEADER>0001104659-23-099828.hdr.sgml : 20230912
<ACCEPTANCE-DATETIME>20230912060428
ACCESSION NUMBER:		0001104659-23-099828
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230912
DATE AS OF CHANGE:		20230912

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Coherus BioSciences, Inc.
		CENTRAL INDEX KEY:			0001512762
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				273615821
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-268252
		FILM NUMBER:		231248942

	BUSINESS ADDRESS:	
		STREET 1:		C/O DENNIS M. LANFEAR
		STREET 2:		333 TWIN DOLPHIN DR, SUITE 600
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94065
		BUSINESS PHONE:		(650) 649-3530

	MAIL ADDRESS:	
		STREET 1:		C/O DENNIS M. LANFEAR
		STREET 2:		333 TWIN DOLPHIN DR, SUITE 600
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94065

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BioGenerics, Inc.
		DATE OF NAME CHANGE:	20110210
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>tm2315859-2_424b5.htm
<DESCRIPTION>424B5
<TEXT>
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    <title>tm2315859-2_424b5 - none - 4.515614s</title>
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  <body style="margin-left:auto;margin-right:auto;width:595.31pt;">
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="margin-top:27.85pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:right; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.125pt;">&#8202;</font><font style="letter-spacing:-0.022pt;">Filed Pursuant to Rule&#160;424(b)(5)</font>&#8203;</div>
        <div style="margin-top:2pt; text-align:right; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.125pt;">&#8202;</font><font style="letter-spacing:-0.022pt;">Registration No. 333-268252</font>&#8203;</div>
        <div style="margin-top:6pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.125pt;">PROSPECTUS </font>
        </div>
        <div style="margin-top:4.3pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 3pt; line-height: 0pt; border-bottom: 3pt solid #000000; ">&#8203;</div>
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        <div style="margin-top:14pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-size:14pt;">
          <font style="letter-spacing:-0.175pt;">U</font><font style="letter-spacing:-0.032pt;">p to</font><font style="letter-spacing:-0.175pt;"> $78,407,207</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="position:relative;margin-top:7.8pt; text-align:center; width:456pt;">
          <img src="lg_coherusbio-4c.jpg" alt="[MISSING IMAGE: lg_coherusbio-4c.jpg]" height="68" width="126" >
        </div>
        <div style="margin-top:16.6pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-size:14pt;">
          <font style="letter-spacing:-0.175pt;">C</font><font style="letter-spacing:-0.032pt;">ommon</font><font style="letter-spacing:-0.175pt;"> S</font><font style="letter-spacing:-0.032pt;">tock</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:6pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We previously entered into a sales agreement with Cowen and Company, LLC, or TD Cowen, dated as of November 8, 2022 and as amended on May 15, 2023 and September 11, 2023, relating to shares of our common stock, $0.0001 par value per share, offered by this prospectus supplement and the accompanying prospectus. In accordance with the terms of the sales agreement, as amended, we may offer and sell from time to time shares of our common stock having an aggregate offering price of up to&#160;$92,500,000 through TD Cowen acting as our agent. The amendment to the sales agreement,&#160;dated May 15, 2023, or Amendment No. 1, reduced the aggregate offering price under the sales agreement from $150,000,000 to $63,750,000. The second amendment to the Sales Agreement, or Amendment No.&#160;2, dated September 11, 2023 increased the aggregate offering price under the sales agreement from $63,750,000 to $92,500,000. Through the date of this prospectus supplement, we have issued 2,048,334 shares of common stock pursuant to the sales agreement for gross proceeds of $14.1 million. As of the date of this prospectus supplement, $78,407,207 of shares of common stock remains available for sale under the sales agreement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:5pt; width:456pt; line-height:10.5pt;">
          <font style="letter-spacing:-0.025pt;">Our common stock is listed on the Nasdaq Global Market under the symbol &#8220;CHRS.&#8221; On September&#160;8, 2023, the last reported sale price of our common stock on the Nasdaq Global Market was $4.89 per share.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:5pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Subject to the terms and conditions of the sales agreement, TD Cowen may sell the common stock by any methods deemed to be an &#8220;at the market&#8221; offering as defined in Rule&#160;415 promulgated under the Securities Act of 1933, as amended, or the Securities Act, including sales made directly on the Nasdaq Global Market, or as otherwise agreed upon by TD Cowen and us. TD Cowen is not required to sell any specific amount of securities, but will act as sales agent using its commercially reasonable efforts consistent with its normal trading and sales practices, on mutually agreed terms between TD Cowen and us. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:5pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The compensation to TD Cowen for sales of common stock sold pursuant to the sales agreement will be an amount up to 3.0% of the gross proceeds of any shares of common stock sold under the sales agreement. In connection with the sale of the common stock on our behalf, TD Cowen will be deemed to be an &#8220;underwriter&#8221; within the meaning of the Securities Act and the compensation of TD Cowen will be deemed to be underwriting commissions or discounts. We have agreed to reimburse TD Cowen for certain of its out-of-pocket expenses. We have also agreed to provide indemnification and contribution to TD Cowen with respect to certain liabilities, including liabilities under the Securities Act or the Securities Exchange Act of 1934, as amended, or the Exchange Act.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:-4.1pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&nbsp;&nbsp;&nbsp;</font>
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        <div style="margin-top:2.4pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #5ACE5A; ">&#8203;</div>
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        <div style="text-indent:20pt; margin-top:9.9pt; width:456pt; line-height:11.5pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Investing in our common stock involves a high degree of risk. Before making an investment decision, please read the information under &#8220;Risk Factors&#8221; beginning on page </font><font style="letter-spacing:-0.125pt;"><a href="#sRIFA">S-6</a></font><font style="letter-spacing:-0.022pt;"> of this prospectus and in the documents incorporated by reference into this prospectus.</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:5pt; width:456pt; line-height:11.5pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:18pt;font-weight:bold;font-size:16pt;">
          <font style="letter-spacing:-0.2pt;">TD </font><font style="letter-spacing:-0.036pt;">Cowen</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.32pt;"> </font>
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        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">The date of this prospectus is September </font><font style="letter-spacing:-0.125pt;">11, 2023.</font>
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        <div style="margin-top:-4.1pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&nbsp;&nbsp;&nbsp;</font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #5ACE5A; ">&#8203;</div>
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      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="TOC">&#8203;</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;height:660pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">TABLE OF CONTENTS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <table style="width:456pt;height:175pt;margin-top:20pt;border-collapse: collapse;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sATP"><font style="letter-spacing:-0.025pt;">ABOUT THIS PROSPECTUS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sATP">S-2</a></font> <a href="#sATP"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sPRSU"><font style="letter-spacing:-0.025pt;">PROSPECTUS SUMMARY </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sPRSU">S-3</a></font> <a href="#sPRSU"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sTHOF"><font style="letter-spacing:-0.025pt;">THE OFFERING </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sTHOF">S-5</a></font> <a href="#sTHOF"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sRIFA"><font style="letter-spacing:-0.025pt;">RISK FACTORS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sRIFA">S-6</a></font> <a href="#sRIFA"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sCNRF"><font style="letter-spacing:-0.025pt;">CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sCNRF">S-8</a></font> <a href="#sCNRF"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sUOP"><font style="letter-spacing:-0.025pt;">USE OF PROCEEDS </font></a>
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            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sUOP">S-10</a></font> <a href="#sUOP"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sDIL"><font style="letter-spacing:-0.025pt;">DILUTION </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sDIL">S-11</a></font> <a href="#sDIL"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sPOD"><font style="letter-spacing:-0.025pt;">PLAN OF DISTRIBUTION </font></a>
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            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:22.5pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#sPOD">S-13</a></font> <a href="#sPOD"></a></td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:431pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#sLEMA"><font style="letter-spacing:-0.025pt;">LEGAL MATTERS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.445pt;width:0pt;">&#8203;</td>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">EXPLANATORY NOTE</font>
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          <font style="letter-spacing:-0.025pt;">We previously entered into a sales agreement with TD Cowen, dated November 8, 2022, or the sales agreement, pursuant to which we may offer and sell up to $150,000,000 of shares of our common stock from time to time through TD Cowen acting as agent. On May 15, 2023, we amended our sales agreement with TD Cowen, pursuant to which we reduced the aggregate offering price under the sales agreement from $150,000,000 to $63,750,000. On September 11, 2023, we further amended our sales agreement with TD Cowen, pursuant to which we increased the aggregate offering price under the sales agreement from $63,750,000 to $92,500,000. Additionally, as of the date of this prospectus supplement, we have issued 2,048,334 shares of common stock pursuant to the sales agreement for gross proceeds of $14.1&#160;million. Therefore, as of the date of this prospectus, there is $78,407,207 of shares of our common stock available for issuance pursuant to the sales agreement, which may be offered and sold under this prospectus supplement. This prospectus supplement amends and restates our previous prospectus supplement filed in connection with the sales agreement on November 17, 2022 with the Securities and Exchange Commission, or the SEC.</font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">ABOUT THIS PROSPECTUS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">This prospectus relates to the offering of our common stock. Before buying any of the common stock that we are offering, we urge you to carefully read this prospectus, together with the information incorporated by reference as described under the headings &#8220;Where You Can Find More Information&#8221; and &#8220;Information Incorporated by Reference&#8221; in this prospectus. These documents contain important information that you should consider when making your investment decision.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">This prospectus describes the terms of this offering of common stock and also adds to and updates information contained in the documents incorporated by reference into this prospectus. To the extent there is a conflict between the information contained in this prospectus, on the one hand, and the information contained in any document incorporated by reference into this prospectus that was filed with the SEC before the date of this prospectus, on the other hand, you should rely on the information in this prospectus. If any statement in one of these documents is inconsistent with a statement in another document having a later date (for example, a document incorporated by reference into this prospectus) the statement in the document having the later date modifies or supersedes the earlier statement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">We have not, and the sales agent has not, authorized anyone to provide you with information in addition to or different from that contained in this prospectus. We are not, and the sales agent is not, making an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. You should assume that the information appearing in this prospectus, the documents incorporated by reference in this prospectus, and in any free writing prospectus that we have authorized for use in connection with this offering, is accurate only as of the date of those respective documents. Our business, financial condition, results of operations and prospects may have changed since those dates. You should read this prospectus, the documents incorporated by reference in this prospectus, and any free writing prospectus that we have authorized for use in connection with this offering, in their entirety before making an investment decision.</font>
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            <font style="text-transform:uppercase;letter-spacing:-0.125pt;">PROSPECTUS SUMMARY</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
          </div>
          <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:11.5pt;font-style:italic;">This summary does not contain all of the information you should consider before buying our common stock. You should read the entire prospectus carefully, especially the &#8220;Risk Factors&#8221; section beginning on page <a href="#sRIFA">S-6</a>, our most recent annual report on Form 10-K as well as in our most recent quarterly report on Form 10-Q and our consolidated financial statements and the related notes incorporated by reference into this prospectus, before deciding to invest in our common stock.<font style="font-style:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
          <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
            <font style="letter-spacing:-0.022pt;">The Company</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:11.5pt;">
            <font style="letter-spacing:-0.025pt;">We are a commercial-stage biopharmaceutical company focused on the research, development and commercialization of innovative immunotherapies to treat cancer. Our strategy is to build a leading immuno-oncology franchise funded with cash generated from net sales of our diversified portfolio of therapeutics approved by the United States Food and Drug Administration, or FDA.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">Our commercial portfolio includes three FDA-approved biosimilar products. Our first product, UDENYCA</font><font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:-0.019pt;">&#174;</font><font style="letter-spacing:-0.025pt;">, a biosimilar to Neulasta</font><font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:-0.019pt;">&#174;</font><font style="letter-spacing:-0.025pt;">, a long-acting granulocyte-colony stimulating factor, or G-CSF, was launched commercially in the United States in January&#160;2019. The FDA approved the prior approval supplement, or PAS, for an autoinjector, or AI, presentation of UDENYCA on March 3, 2023, and on May 22, 2023 we announced the availability of UDENYCA AI for commercial sale. The FDA review of the PAS for our third pegfilgrastim presentation, the UDENYCA</font><font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:-0.019pt;">&#174;</font><font style="letter-spacing:-0.025pt;"> on-body injector, or OBI, is ongoing, and we plan to launch the UDENYCA OBI commercially pending potential approval, which we expect to receive later this year. Our second product, CIMERLI (ranibizumab-eqrn), was approved by the FDA in August 2022 as a biosimilar product interchangeable with Lucentis (ranibizumab injection) for the treatment of neovascular (wet) age-related macular degeneration, macular edema following retinal vein occlusion, diabetic macular edema, diabetic retinopathy, and myopic choroidal neovascularization. The FDA also granted CIMERLI 12 months of first interchangeable exclusivity. We launched CIMERLI commercially in the United States in October 2022. We launched our third product, YUSIMRY (adalimumab-aqvh), a biosimilar to Humira (adalimumab), in the United States in July 2023.</font>
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          <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">In addition to our three FDA-approved biosimilar products, we also have an original biologic license application, or original BLA, submitted under Section&#160;351(a) of the Public Health Service Act under review by the FDA for toripalimab. The original BLA for toripalimab is seeking approval for the use of toripalimab in combination with gemcitabine and cisplatin for first-line treatment of adults with metastatic or recurrent locally advanced nasopharyngeal carcinoma, or NPC, and for use as a monotherapy in the second- or later-line treatment of patients with recurrent unresectable or metastatic NPC that have progressed on or after a platinum-containing chemotherapy. The FDA completed manufacturing facility inspections in May 2023 and has scheduled the inspection of clinical sites (biomedical research monitoring inspections) in the third quarter of 2023. We anticipate a potential approval decision on the original BLA for toripalimab in the United States in the second half of 2023. If approved, toripalimab would be launched using our existing oncology commercial infrastructure.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">We have built an experienced and robust oncology sales, market access, key account management and medical affairs capability in the United States, which have supported the successful commercialization of UDENYCA and CIMERLI and the recent commercial launch of YUSIMRY. We expect to leverage these capabilities as we build and launch our immuno-oncology franchise, continue to grow our ophthalmology product portfolio and launch the commercialization of other biosimilar products.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">On June 15, 2023, we entered into an Agreement and Plan of Merger, or the Merger Agreement, by and among us, Crimson Merger Sub I, Inc., a Delaware corporation and our wholly owned subsidiary, or Merger Sub I, Crimson Merger Sub II, LLC, a Delaware limited liability company and our wholly owned subsidiary, or Merger Sub II and together with Merger Sub I, the Merger Subs, and Surface Oncology, Inc., a Delaware corporation, or Surface. Pursuant to the Merger Agreement, and subject to the terms and conditions set forth therein, Merger Sub I merged with and into Surface, or the First Merger, with Surface surviving such First Merger as our wholly owned subsidiary and, as part of the same overall transaction, promptly after the First Merger, the surviving corporation of the First Merger merged </font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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            <font style="letter-spacing:-0.025pt;">with and into Merger Sub II, or the Second Merger and together with the First Merger, the Mergers, with Merger Sub II surviving the Second Merger, or the Surviving Entity. Merger Sub II&#39;s name was changed to Surface Oncology, LLC. The acquisition of Surface closed on September 8, 2023.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">Through our acquisition of Surface, our immuno-oncology pipeline now includes multiple antibody immunotherapy candidates. Casdozokitug (formerly SRF388) is a novel anti-IL-27 antibody currently being evaluated in Phase 1/2 clinical trials in lung and liver cancer. CHS-114 (formerly SRF114) is a highly selective, competitively positioned anti-CCR8 antibody currently in a Phase 1/2 study as a monotherapy in patients with advanced solid tumors. We also have two out-licensed next-generation cancer therapy partnership programs with Novartis Institutes for Biomedical Research, Inc. and GlaxoSmithKline Intellectual Property (No. 4) Limited.</font>
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            <font style="letter-spacing:-0.025pt;">Our earlier-stage immuno-oncology pipeline includes CHS-006, a TIGIT-targeted antibody currently being evaluated in a Phase 1/2 clinical trial in combination with toripalimab, and CHS-1000, a preclinical program targeting the novel pathway ILT4.</font>
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          <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">We were incorporated in the State of Delaware in September&#160;2010 under the name BioGenerics, Inc. We subsequently changed the name of the corporation in April&#160;2012 to Coherus BioSciences, Inc. Our principal executive offices are located at 333 Twin Dolphin Drive, Suite 600, Redwood City, California&#160;94065, and our telephone number is (650) 649-3530. Our website address is https://&#160;www.coherus.com. The information contained in or that can be accessed through our website is not part of this prospectus. We also use our website as a means of disclosing material non-public information and for complying with our disclosure obligations under Regulation&#160;FD. </font>
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            <font style="text-transform:uppercase;letter-spacing:-0.125pt;">THE OFFERING</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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              <font style="letter-spacing:-0.025pt;">Common stock offered by us </font>
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          <div style="margin-left:145pt; margin-top:-12pt; width:311pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">Shares of our common stock having an aggregate offering price of up to $78,407,207.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:-0.025pt;">Common stock to be outstanding after this </font>
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              <font style="letter-spacing:-0.025pt;">offering </font>
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          <div style="margin-left:145pt; margin-top:-12pt; width:311pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">110,476,207 shares, assuming sales of 16,034,193 shares of our common stock in this offering at an offering price of $4.89 per share, which was the last reported sale price of our common stock on the Nasdaq Global Market on September 8, 2023. The actual number of shares issued will vary depending on the sales price under this offering. </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:-0.025pt;">Plan of Distribution </font>
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          <div style="margin-left:145pt; margin-top:-12pt; width:311pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">&#8220;At the market offering&#8221; that may be made from time to time through our sales agent, TD Cowen. See &#8220;Plan of Distribution&#8221; on page <a href="#sPOD">S-13</a>.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:-0.025pt;">Use of Proceeds </font>
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          <div style="margin-left:145pt; margin-top:-12pt; width:311pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">We intend to use the net proceeds from this offering, if any, for general corporate purposes. See &#8220;Use of Proceeds&#8221; on page <a href="#sUOP">S-10</a>.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:-0.025pt;">Risk Factors </font>
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          <div style="margin-left:145pt; margin-top:-12pt; width:311pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">You should read the &#8220;Risk Factors&#8221; section of this prospectus and in the documents incorporated by reference in this prospectus for a discussion of factors to consider before deciding to purchase shares of our common stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <div style="margin-left:10pt; text-indent:-10pt; margin-top:6pt; line-height:12pt;">
              <font style="letter-spacing:-0.025pt;">Symbol on the Nasdaq Global Market </font>
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            <font style="letter-spacing:-0.025pt;">&#8220;CHRS&#8221;</font>
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          <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
            <font style="letter-spacing:-0.025pt;">The number of shares of common stock to be outstanding after this offering is based on 94,442,014 shares of our common stock outstanding as of June 30, 2023, and excludes:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:-0.025pt;">24,351,670 shares of common stock issuable upon the exercise of outstanding stock options having a weighted-average exercise price of $13.4731 per share and 2,209,182 shares of common stock issuable upon the vesting of restricted stock&#160;units, granted under our 2010 Equity Incentive Plan, as amended, our 2014 Equity Incentive Award Plan and our 2016 Employment Commencement Incentive Plan;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:-0.025pt;">2,124,048 shares of common stock reserved for issuance pursuant to future awards under our 2014 Equity Incentive Award Plan and any future increases in the number of shares of our common stock reserved for future issuance under this plan, as well as our 2016 Employment Commencement Incentive Plan;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:-0.025pt;">2,850,445 shares of common stock reserved for future issuance under our 2014 Employee Stock Purchase Plan, as well as any future increases in the number of shares of our common stock reserved for future issuance under this plan;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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            <font style="letter-spacing:-0.025pt;">11,942,152 shares of common stock issuable upon the conversion of our senior subordinated convertible notes. The senior subordinated convertible notes are convertible at the option of the holder at any time prior to the close of business on the second scheduled trading day immediately preceding April&#160;15, 2026 at the initial conversion rate of 51.9224 shares of common stock per $1,000 principal amount of senior convertible notes, which is equivalent to an initial conversion price of approximately $19.26 per share, and is subject to adjustment in certain events; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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            <font style="letter-spacing:-0.025pt;">approximately 12.2 million shares of common stock to be issued to the holders of outstanding common stock, restricted stock units and options to purchase common stock of Surface in connection with our acquisition of Surface that closed on September 8, 2023.</font>
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          <font style="letter-spacing:-0.025pt;">S-5</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="sRIFA">&#8203;</a>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">RISK FACTORS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;font-style:italic;">You should consider carefully the risks described below and discussed under the section captioned &#8220;Risk Factors&#8221; contained in our most recent annual report on Form 10-K and quarterly report on Form 10-Q, as updated by our subsequent filings under the Exchange Act, each of which is incorporated by reference in this prospectus in their entirety, together with other information in this prospectus, and the information and documents incorporated by reference in this prospectus, and any free writing prospectus that we have authorized for use in connection with this offering before you make a decision to invest in our common stock. If any of the following events actually occur, our business, operating results, prospects or financial condition could be materially and adversely affected. This could cause the trading price of our common stock to decline and you may lose all or part of your investment. The risks described below are not the only ones that we face. Additional risks not presently known to us or that we currently deem immaterial may also affect our business operations.<font style="font-style:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Risks Relating to this Offering</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:4pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;">Our management team may invest or spend the proceeds of this offering in ways with which you may not agree or in ways which may not yield a significant return.<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Our management will have broad discretion over the use of proceeds from this offering. We intend to use the net proceeds from this offering for general corporate purposes, which may include, among other things, increasing our working capital and funding research and development, commercial activities, and capital expenditures. Our management will have considerable discretion in the application of the net proceeds, and you will not have the opportunity, as part of your investment decision, to assess whether the proceeds are being used appropriately. The net proceeds may be used for corporate purposes that do not increase our operating results or enhance the value of our common stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:4pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;">You may experience immediate and substantial dilution in the net tangible book value per share of the common stock you purchase in this offering.<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The price per share of our common stock being offered may be higher than the net tangible book value per share of our common stock outstanding prior to this offering. Assuming that an aggregate of 16,034,193 shares are sold at a price of $4.89 per share, the last reported sale price of our common stock on the Nasdaq Global Market on September 8, 2023, for aggregate proceeds of approximately $78.4 million in this offering, and after deducting commissions and estimated aggregate offering expenses payable by us, you will suffer immediate and substantial dilution of $5.84 per share, representing the difference between the as-adjusted net tangible book value per share of our common stock as of June&#160;30, 2023 after giving effect to this offering and the assumed offering price. See the section entitled &#8220;Dilution&#8221; below for a more detailed discussion of the dilution you will incur if you purchase common stock in this offering.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:4pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;">You may experience future dilution as a result of future equity offerings.<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">In order to raise additional capital, we may in the future offer additional shares of our common stock or other securities convertible into or exchangeable for our common stock. We cannot assure you that we will be able to sell shares or other securities in any other offering at a price per share that is equal to or greater than the price per share paid by investors in this offering, and investors purchasing shares or other securities in the future could have rights superior to existing stockholders. The price per share at which we sell additional shares of our common stock or other securities convertible into or exchangeable for our common stock in future transactions may be higher or lower than the price per share in this offering.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:4pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;">The actual number of shares of common stock we will issue under the sales agreement, at any one time or in total, is uncertain.<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Subject to certain limitations in the sales agreement and compliance with applicable law, we have the discretion to deliver a placement notice to our sales agent at any time throughout the term of the sales agreement. The per share price of the shares of common stock that are sold by the sales agent after delivering a placement notice will fluctuate based on the market price of our common stock during the sales period and limits we set with our sales agent. Because the price per share of each share of </font>
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          <font style="letter-spacing:-0.025pt;">S-6</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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      <div style="margin-top:6pt;margin-bottom:478pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">common stock sold will fluctuate based on the market price of our common stock during the sales period, it is not possible at this stage to predict the number of shares of common stock that will ultimately be issued.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:4pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;">The common stock offered hereby will be sold in &#8220;at the market offerings,&#8221; and investors who purchase shares at different times will likely pay different prices.<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Investors who purchase shares in this offering at different times will likely pay different prices, and therefore may experience different outcomes in their investment results. Although we will act in good faith in the best interests of the Company, we will have discretion, subject to market demand, to vary the timing, prices and number of shares sold. In addition, subject to any restrictions we may place in any applicable placement notice delivered to TD Cowen, there is no minimum or maximum sales price for shares to be sold in this offering. Investors may experience a decline in the value of their shares as a result of share sales made at prices lower than the prices they paid. </font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="sCNRF">&#8203;</a>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">This prospectus and the documents incorporated by reference herein contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 concerning our business, operations and financial performance and condition, as well as our plans, objectives and expectations for our business operations and financial performance and condition. Any statements contained or incorporated by reference herein that are not statements of historical facts may be deemed to be forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as &#8220;aim,&#8221; &#8220;anticipate,&#8221; &#8220;assume,&#8221; &#8220;believe,&#8221; &#8220;contemplate,&#8221; &#8220;continue,&#8221; &#8220;could,&#8221; &#8220;due,&#8221; &#8220;estimate,&#8221; &#8220;expect,&#8221; &#8220;goal,&#8221; &#8220;intend,&#8221; &#8220;may,&#8221; &#8220;objective,&#8221; &#8220;plan,&#8221; &#8220;predict,&#8221; &#8220;potential,&#8221; &#8220;positioned,&#8221; &#8220;seek,&#8221; &#8220;should,&#8221; &#8220;target,&#8221; &#8220;will,&#8221; &#8220;would&#8221; and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. These forward-looking statements include, but are not limited to, statements about:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">whether we will be able to continue to maintain or increase sales for our products;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">our expectations regarding our ability to develop and commercialize toripalimab, CHS-006 and our other product candidates in the United States and Canada, including whether the trial results, data package or biologics license application for toripalimab will be sufficient to support regulatory approval;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">our ability to address comments raised in the complete response letter for the original BLA for toripalimab and timing of the review for the original BLA resubmission for toripalimab;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" margin-top:2.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our ability to receive marketing authorization for the on-body injector presentation of UDENYCA, including the timing of receiving such marketing authorization, if approved;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our ability to maintain regulatory approval for our products and our ability to obtain and maintain regulatory approval of our product candidates, if and when approved;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our expectations regarding government and third-party payer coverage and reimbursement;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.09pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.09pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">our ability to realize the anticipated benefits from the acquisition of Surface;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our ability to manufacture our product candidates in conformity with regulatory requirements and to scale up manufacturing capacity of these products for commercial supply;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our reliance on third-party contract manufacturers to supply our products and product candidates for us;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our expectations regarding the potential market size and the size of the patient populations for our products and product candidates, if approved for commercial use;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our expectations about making required future interest and principal payments as they become due in connection with our debt obligations;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our financial performance, including, but not limited to, projected future performance of our gross margins, research and development expenses and selling and general administrative expenses;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the implementation of strategic plans for our business, products and product candidates;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the initiation, timing, progress and results of future preclinical and clinical studies and our research and development programs;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the scope of protection we are able to establish and maintain for intellectual property rights covering our products and product candidates;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">our ability to finalize the definitive agreements contemplated by the binding term sheet between us and Klinge Biopharma GmbH for the exclusive commercialization rights to FYB203, a biosimilar candidate to Eylea</font><font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:-0.019pt;">&#174;</font><font style="letter-spacing:-0.025pt;"> (aflibercept), in the United States or close on the transactions contemplated by them;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our expectations regarding the scope or enforceability of third-party intellectual property rights, or the applicability of such rights to our products and product candidates;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the cost, timing and outcomes of litigation involving our products and product candidates;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">our reliance on third-party contract research organizations to conduct clinical trials of our product candidates;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the benefits of the use of our products and product candidates;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">S-8</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:350pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the rate and degree of market acceptance of our current or any future products and product candidates;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">our ability to compete with companies currently producing competitor products, including Neulasta, Humira and Lucentis and other biosimilar products made by other companies;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">developments and projections relating to our competitors, our market opportunity and our industry; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the potential impact of COVID-19 and the continuation of the war in Ukraine on our business and prospects.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">These forward-looking statements are based on management&#8217;s current expectations, estimates, forecasts and projections about our business and the industry in which we operate and management&#8217;s beliefs and assumptions and are not guarantees of future performance or development and involve known and unknown risks, uncertainties and other factors that are in some cases beyond our control. As a result, any or all of our forward-looking statements in this prospectus may turn out to be inaccurate. Factors that may cause actual results to differ materially from current expectations include, among other things, those listed under the section titled &#8220;Risk Factors&#8221; and elsewhere in this prospectus and the documents incorporated by reference herein. Potential investors are urged to consider these factors carefully in evaluating the forward-looking statements. These forward-looking statements speak only as of the date of this prospectus. Except as required by law, we assume no obligation to update or revise these forward-looking statements for any reason, even if new information becomes available in the future. You should, however, review the factors and risks we describe in the reports we will file from time to time with the SEC after the date of this prospectus. See the section titled &#8220;Where You Can Find More Information.&#8221; </font>
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      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">S-9</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="sUOP">&#8203;</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-bottom:470pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">USE OF PROCEEDS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The amount of proceeds from this offering will depend upon the number of shares of our common stock sold and the market price at which they are sold. There can be no assurance that we will be able to sell any shares under or fully utilize the sale agreement with TD Cowen as a source of financing. We intend to use the net proceeds, if any, from this offering for general corporate purposes.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The amounts and timing of our actual expenditures will depend on numerous factors as well as the amount of cash used in our operations. We therefore cannot estimate with certainty the amount of net proceeds to be used for the purposes described above. We may find it necessary or advisable to use the net proceeds for other purposes, and we will have broad discretion in the application of the net proceeds. Pending the uses described above, we plan to invest the net proceeds from this offering in short-term, investment-grade, interest-bearing securities. </font>
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      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">S-10</font>
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      <hr >
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="sDIL">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">DILUTION</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Our net tangible book value (deficit) as of June 30, 2023 was approximately ($180.6) million, or ($1.91) per share. Net tangible book value per share is determined by dividing our total tangible assets, less total liabilities, by the number of shares of our common stock outstanding at June&#160;30, 2023 of 94,442,014. Dilution in net tangible book value per share represents the difference between the amount per share paid by purchasers of shares of common stock in this offering and the as adjusted net tangible book value per share of our common stock immediately after giving effect to this offering.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">After giving effect to the assumed sale of our common stock in the aggregate amount of $78,407,207 in this offering at an assumed offering price of $4.89, the last reported sale price of our common stock on the Nasdaq Global Market on September 8, 2023, and after deducting commissions and estimated aggregate offering expenses payable by us, our as adjusted net tangible book value as of June&#160;30, 2023 would have been approximately $(104.6)&#160;million, or $(0.95) per share. This represents an immediate increase in net tangible book value of $0.97 per share to existing stockholders and immediate dilution in net tangible book value of $5.84 per share to new investors purchasing our common stock in this offering. The following table illustrates this dilution on a per share basis:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <table style="width:456pt;height:95pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; width:385.33pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:-0.025pt;">Assumed public offering price per share </font>
              </div>
            </td>
            <td style="padding:0pt; width:1pt;">&#8203;</td>
            <td style="padding:0pt; width:1pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:6pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:21.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; min-width:6pt; text-align:right; ">$</td>
            <td style="padding:0pt 0pt 1pt 0pt; min-width:21.75pt; text-align:right; white-space:nowrap;">4.89 </td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:385.33pt;text-align:left;">
              <div style="margin-left:10pt;">
                <font style="letter-spacing:-0.025pt;">Net tangible book value (deficit) per share as of June 30, 2023 </font>
              </div>
            </td>
            <td style="padding:0pt; width:1pt;">&#8203;</td>
            <td style="padding:0pt; width:1pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:6pt; text-align:right; ">$</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:21.75pt; text-align:right; white-space:nowrap;">(1.91<font style="position:absolute;">)</font></td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:6pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt; min-width:21.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:0pt;">&#8203;</td>
            <td style="border-bottom:1px solid #CCEEFF;padding:2.167pt 0pt 1.833pt 0pt; width:385.33pt;white-space:normal;text-align:left;">
              <div style="margin-left:20pt; text-indent:-10pt;">
                <font style="letter-spacing:-0.025pt;">Increase in net tangible book value per share attributable to new investors in this offering </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:1pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:1pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:2.167pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:6pt; text-align:right; ">&#8203;</td>
            <td style="padding:2.167pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:21.75pt; text-align:right; white-space:nowrap;">0.97 </td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt;border-bottom:1px solid #CCEEFF; min-width:6pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt;border-bottom:1px solid #CCEEFF; min-width:21.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #CCEEFF;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #CCEEFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:12pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
            <td style="border-bottom:1px solid #FFFFFF;padding:1.917pt 0pt 1.833pt 0pt; width:385.33pt;text-align:left;">
              <div style="margin-left:10pt; text-indent:-10pt;">
                <font style="letter-spacing:-0.025pt;">As adjusted net tangible book value per share as of June 30, 2023 after this </font>
                <br >
                <font style="letter-spacing:-0.025pt;">offering </font>
              </div>
            </td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:1pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:1pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #FFFFFF;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt;border-bottom:1px solid #FFFFFF; min-width:6pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt;border-bottom:1px solid #FFFFFF; min-width:21.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #FFFFFF;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:1.917pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:6pt; text-align:right; ">&#8203;</td>
            <td style="padding:1.917pt 0pt 1.833pt 0pt;border-bottom:1px solid #000000; min-width:21.75pt; text-align:right; white-space:nowrap;">(0.95<font style="position:absolute;">) </font></td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:1px solid #000000;">&#8203;</td>
            <td style="padding:0pt;border-bottom:1px solid #FFFFFF; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.25pt 0pt 3.25pt 0pt; width:385.33pt;text-align:left;">
              <div style="white-space:nowrap;">
                <font style="letter-spacing:-0.025pt;">Dilution per share to new investors purchasing shares in this offering </font>
              </div>
            </td>
            <td style="padding:0pt; width:1pt;">&#8203;</td>
            <td style="padding:0pt; width:1pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt;padding-bottom:1.75pt; min-width:6pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 0.5pt 0pt;padding-bottom:1.75pt; min-width:21.75pt; text-align:right; white-space:nowrap;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt; width:6pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:3pt double #000000;">&#8203;</td>
            <td style="padding:3.25pt 0pt 2.5pt 0pt;border-bottom:3pt double #000000; min-width:6pt; text-align:right; ">$</td>
            <td style="padding:3.25pt 0pt 2.5pt 0pt;border-bottom:3pt double #000000; min-width:21.75pt; text-align:right; white-space:nowrap;">5.84</td>
            <td style="padding:0pt;padding-left:0pt;width:0pt;border-bottom:3pt double #000000;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
        </table>
        <div style="text-indent:20pt; margin-top:13.3pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The shares sold in this offering, if any, will be sold from time to time at various prices. An increase of $1.00 per share in the price at which the shares are sold from the assumed offering price of $4.89 per share shown in the table above, assuming all of our common stock in the aggregate amount of $78,407,207 is sold at that price, would decrease our as adjusted net tangible book value per share after the offering to $(0.97) per share and would increase the dilution in net tangible book value per share to new investors to $6.86 per share, after deducting commissions and estimated aggregate offering expenses payable by us. A decrease of $1.00 per share in the price at which the shares are sold from the assumed offering price of $4.89 per share shown in the table above, assuming all of our common stock in the aggregate amount of $78,407,207 is sold at that price, would increase our as adjusted net tangible book value per share after the offering to $(0.91) per share and would decrease the dilution in net tangible book value per share to new investors to $4.80 per share, after deducting commissions and estimated aggregate offering expenses payable by us. This information is supplied for illustrative purposes only.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">To the extent that outstanding options or warrants are exercised or outstanding restricted stock&#160;units vest, investors purchasing our common stock in this offering will experience further dilution. In addition, we may choose to raise additional capital due to market conditions or strategic considerations even if we believe we have sufficient funds for our current or future operating plans. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the issuance of these securities could result in further dilution to our stockholders.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The foregoing table and calculations (other than historical net tangible book value) are based on 94,442,014 shares of our common stock outstanding as of June 30, 2023, and excludes:</font>
        </div>
        <div style=" float:left; line-height:12pt; margin-top:2.2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
        </div>
        <div style=" margin-top:2.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">24,351,670 shares of common stock issuable upon the exercise of outstanding stock options having a weighted-average exercise price of $13.4731 per share and 2,209,182 shares of common stock issuable upon the vesting of restricted stock units, granted under our 2010 Equity Incentive Plan, as amended, our 2014 Equity Incentive Award Plan and our 2016 Employment Commencement Incentive Plan;</font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
      </div>
      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">S-11</font>
          <br >
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:430pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
        </div>
        <div style=" line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">2,124,048 shares of common stock reserved for issuance pursuant to future awards under our 2014 Equity Incentive Award Plan and any future increases in the number of shares of our common stock reserved for future issuance under this plan, as well as our 2016 Employment Commencement Incentive Plan;</font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
        </div>
        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">2,850,445 shares of common stock reserved for future issuance under our 2014 Employee Stock Purchase Plan, as well as any future increases in the number of shares of our common stock reserved for future issuance under this plan;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
        </div>
        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">11,942,152 shares of common stock issuable upon the conversion of our senior subordinated convertible notes. The senior subordinated convertible notes are convertible at the option of the holder at any time prior to the close of business on the second scheduled trading day immediately preceding April 15, 2026 at the initial conversion rate of 51.9224 shares of common stock per $1,000 principal amount of senior convertible notes, which is equivalent to an initial conversion price of approximately $19.26 per share, and is subject to adjustment in certain events; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
        </div>
        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">approximately 12.2 million shares of common stock to be issued to the holders of outstanding common stock, restricted stock units and options to purchase common stock of Surface in connection with our acquisition of Surface that closed on September 8, 2023. </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">S-12</font>
          <br >
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="sPOD">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">PLAN OF DISTRIBUTION</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We have entered into a sales agreement with TD Cowen, as amended by Amendment No. 1 and Amendment No. 2, under which we may issue and sell from time to time up to $92,500,000 of our common stock through or to TD Cowen as our sales agent or principal, of which $78,407,207 remains available for sale at the time of this prospectus supplement. Sales of our common stock, if any, will be made at market prices by any method that is deemed to be an &#8220;at the market offering&#8221; as defined in Rule&#160;415 under the Securities Act.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:5pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">TD Cowen will offer our common stock subject to the terms and conditions of the sales agreement on a daily basis or as otherwise agreed upon by us and TD Cowen. We will designate the maximum amount of common stock to be sold through TD Cowen on a daily basis or otherwise determine such maximum amount together with TD Cowen. Subject to the terms and conditions of the sales agreement, TD Cowen will use its commercially reasonable efforts to sell on our behalf all of the shares of common stock requested to be sold by us. We may instruct TD Cowen not to sell common stock if the sales cannot be effected at or above the price designated by us in any such instruction. TD Cowen or we may suspend the offering of our common stock being made through TD Cowen under the sales agreement upon proper notice to the other party. TD Cowen and we each have the right, by giving written notice as specified in the sales agreement, to terminate the sales agreement in each party&#8217;s sole discretion at any time.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:5pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The aggregate compensation payable to TD Cowen as sales agent up to 3.0% of the gross sales price of the shares sold through it pursuant to the sales agreement. We have also agreed to reimburse TD Cowen up to $75,000 of actual outside legal expenses incurred by TD Cowen in connection with this offering. We estimate that the total expenses of the offering payable by us, excluding commissions payable to TD Cowen under the sales agreement, will be approximately $450,000.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The remaining sales proceeds, after deducting any expenses payable by us and any transaction fees imposed by any governmental, regulatory, or self-regulatory organization in connection with the sales, will equal our net proceeds for the sale of such common stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">TD Cowen will provide written confirmation to us following the close of trading on the Nasdaq Global Market on each day in which common stock is sold through it as sales agent under the sales agreement. Each confirmation will include the number of shares of common stock sold through it as sales agent on that day, the volume weighted average price of the shares sold and the net proceeds to us.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We will report at least quarterly the number of shares of common stock sold through TD Cowen under the sales agreement, the net proceeds to us and the compensation paid by us to TD Cowen in connection with the sales of common stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Settlement for sales of common stock will occur, unless the parties agree otherwise, on the second business day that is also a trading day following the date on which any sales were made in return for payment of the net proceeds to us. There is no arrangement for funds to be received in an escrow, trust or similar arrangement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">In connection with the sales of our common stock on our behalf, TD Cowen will be deemed to be an &#8220;underwriter&#8221; within the meaning of the Securities Act, and the compensation paid to TD Cowen will be deemed to be underwriting commissions or discounts. We have agreed in the sales agreement to provide indemnification and contribution to TD Cowen against certain liabilities, including liabilities under the Securities Act. As sales agent, TD Cowen will not engage in any transactions that stabilizes our common stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Our common stock is listed on the Nasdaq Global Market and trades under the symbol &#8220;CHRS.&#8221; The transfer agent of our common stock is Equiniti Trust Company Shareowner Services.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">TD Cowen and/or its affiliates have provided, and may in the future provide, various investment banking and other financial services for us for which services they have received and, may in the future receive, customary fees. </font>
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          <font style="letter-spacing:-0.025pt;">S-13</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="sLEMA">&#8203;</a><a name="sEXP">&#8203;</a><a name="sWYCF">&#8203;</a><a name="sIIBR">&#8203;</a>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">LEGAL MATTERS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Latham &amp; Watkins LLP will pass upon certain legal matters relating to the issuance and sale of the securities offered hereby on behalf of Coherus BioSciences, Inc. Cowen and Company, LLC is being represented in connection with this offering by Davis Polk &amp; Wardell LLP, Menlo Park, California.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">EXPERTS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Ernst &amp; Young LLP, independent registered public accounting firm, has audited our consolidated financial statements included in our <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023002917/chrs-20221231x10k.htm">Annual Report on Form 10-K for the year ended December&#160;31, 2022,</a> and the effectiveness of our internal control over financial reporting as of December&#160;31, 2022, as set forth in their reports, which are incorporated by reference in this prospectus and elsewhere in the registration statement. Our financial statements are incorporated by reference in reliance on Ernst &amp; Young LLP&#8217;s reports, given on their authority as experts in accounting and auditing.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">WHERE YOU CAN FIND MORE INFORMATION</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We have filed with the SEC a registration statement on Form S-3 under the Securities Act, of which this prospectus forms a part. The rules and regulations of the SEC allow us to omit from this prospectus certain information included in the registration statement. For further information about us and the securities we are offering under this prospectus, you should refer to the registration statement and the exhibits and schedules filed with the registration statement. With respect to the statements contained in this prospectus regarding the contents of any agreement or any other document, in each instance, the statement is qualified in all respects by the complete text of the agreement or document, a copy of which has been filed as an exhibit to the registration statement or otherwise filed with the&#160;SEC. </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We file reports, proxy statements and other information with the SEC under the Exchange Act. The SEC maintains an Internet website that contains reports, proxy statements and other information about issuers, like us, that file electronically with the SEC. The address of that website is </font><font style="font-style:italic;">www.sec.gov</font><font style="letter-spacing:-0.025pt;">.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">INFORMATION INCORPORATED BY REFERENCE</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The SEC allows us to &#8220;incorporate by reference&#8221; the information we file with them which means that we can disclose important information to you by referring you to those documents instead of having to repeat the information in this prospectus. The information incorporated by reference is considered to be part of this prospectus, and later information that we file with the SEC will automatically update and supersede this information. We incorporate by reference the documents listed below and any future information filed (rather than furnished) with the SEC under Sections&#160;13(a), 13(c), 14, or 15(d) of the Exchange Act between the date of this prospectus and the termination of this offering, provided, however, that we are not incorporating any information furnished under Item&#160;2.02 or Item&#160;7.01 of any current report on Form 8-K:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">This prospectus and any accompanying prospectus supplement incorporate by reference the documents set forth below that have previously been filed with the SEC:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023002917/chrs-20221231x10k.htm">Our Annual Report on Form 10-K for the year ended December 31, 2022, filed with the SEC on March 6, 2023.</a>
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          <font style="letter-spacing:-0.025pt;">Our Quarterly Reports on Form 10-Q for the quarters ended March 31, 2023 and June 30, 2023, filed with the SEC on <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023008529/chrs-20230331x10q.htm">May 8, 2023</a> and <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023012915/chrs-20230630x10q.htm">August 2, 2023</a>, respectively.</font>
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          <font style="letter-spacing:-0.025pt;"><a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023006050/chrs-20230607xdef14a.htm">Our Definitive Proxy Statement on Schedule 14A, filed with the SEC on April 17, 2023</a>, but only to the extent incorporated by reference in our <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023002917/chrs-20221231x10k.htm">Annual Report on Form 10-K for the year ended December&#160;31, 2022.</a></font>
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          <font style="letter-spacing:-0.025pt;">Our Current Reports on Form 8-K filed with the SEC on <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312523007361/d403906d8k.htm">January 13, 2023</a>, <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023002912/chrs-20230302x8k.htm">March 6, 2023, </a><a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312523145220/d443156d8k.htm">May 15, 2023</a><a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312523145220/d443156d8k.htm">,</a> <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312523148266/d480273d8k.htm">May 18, 2023</a>, <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023010652/chrs-20230531x8k.htm">May 31, 2023</a>, <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023010962/chrs-20230607x8k.htm">June 9, 2023</a>, <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312523167305/d492086d8k.htm">June 15, 2023</a>, <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312523168448/d523169d8k.htm">June 16, 2023,</a> <a style="-sec-extract:exhibit" href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023012028/chrs-20230718x8k.htm">July 20, 2023</a> and <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837023015582/chrs-20230908x8k.htm">September 8, 2023</a>.</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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          <a style="-sec-extract:exhibit" href="http://www.sec.gov/Archives/edgar/data/1512762/000119312514393922/d814871d8a12b.htm">The description of our Common Stock contained in our registration statement on Form 8-A, filed with the SEC on November&#160;3, 2014, and any amendment or report filed with the SEC for the purpose of updating the description.</a><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">All reports and other documents we subsequently file pursuant to Section&#160;13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, which we refer to as the &#8220;Exchange Act&#8221; in this prospectus, prior to the termination of this offering but excluding any information furnished to, rather than filed with, the SEC, will also be incorporated by reference into this prospectus and deemed to be part of this prospectus from the date of the filing of such reports and documents.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">You may request a free copy of any of the documents incorporated by reference in this prospectus by writing or telephoning us at the following address:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:8pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Coherus BioSciences, Inc.</font>
          <br >
          <font style="letter-spacing:-0.025pt;">333 Twin Dolphin Drive, Suite 600</font>
          <br >
          <font style="letter-spacing:-0.025pt;">Redwood City, CA 94065</font>
          <br >
          <font style="letter-spacing:-0.025pt;">(650) 649-3530</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Exhibits to the filings will not be sent, however, unless those exhibits have specifically been incorporated by reference in this prospectus or any accompanying prospectus supplement.</font>
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          <font style="letter-spacing:-0.025pt;">S-15</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
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          <font style="letter-spacing:-0.125pt;">PROSPECTUS </font>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 3pt; line-height: 0pt; border-bottom: 3pt solid #000000; ">&#8203;</div>
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          <font style="text-transform:uppercase;letter-spacing:-0.225pt;">Coherus BioSciences, Inc.</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.36pt;"> </font>
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          <font style="text-transform:uppercase;letter-spacing:-0.175pt;">$150,000,000</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.28pt;"> </font>
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          <img src="lg_coherusbio-4c.jpg" alt="[MISSING IMAGE: lg_coherusbio-4c.jpg]" height="102" width="190" >
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          <font style="text-transform:uppercase;letter-spacing:-0.175pt;">Common Stock</font>
          <br >
          <font style="text-transform:uppercase;letter-spacing:-0.175pt;">Preferred Stock</font>
          <br >
          <font style="text-transform:uppercase;letter-spacing:-0.175pt;">Debt Securities</font>
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          <font style="text-transform:uppercase;letter-spacing:-0.175pt;">Warrants</font>
          <br >
          <font style="text-transform:uppercase;letter-spacing:-0.175pt;">Units</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.28pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We may offer and sell up to $150.0&#160;million in the aggregate of the securities identified above from time to time in one or more offerings. This prospectus provides you with a general description of the securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Each time we offer and sell securities, we will provide a supplement to this prospectus that contains specific information about the offering and the amounts, prices and terms of the securities. The supplement may also add, update or change information contained in this prospectus with respect to that offering. You should carefully read this prospectus and the applicable prospectus supplement before you invest in any of our securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We may offer and sell the securities described in this prospectus and any prospectus supplement to or through one or more underwriters, dealers and agents, or directly to purchasers, or through a combination of these methods. If any underwriters, dealers or agents are involved in the sale of any of the securities, their names and any applicable purchase price, fee, commission or discount arrangement between or among them will be set forth, or will be calculable from the information set forth, in the applicable prospectus supplement. See the sections of this prospectus entitled &#8220;About this Prospectus&#8221; and &#8220;Plan of Distribution&#8221; for more information. No securities may be sold without delivery of this prospectus and the applicable prospectus supplement describing the method and terms of the offering of such securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.125pt;">INVESTING IN OUR SECURITIES INVOLVES RISKS. SEE THE &#8220;RISK FACTORS&#8221; ON PAGE <a href="#bRIFA">6</a> OF&#160;THIS PROSPECTUS AND ANY SIMILAR SECTION CONTAINED IN THE APPLICABLE PROSPECTUS SUPPLEMENT CONCERNING FACTORS YOU SHOULD CONSIDER BEFORE INVESTING IN OUR SECURITIES.</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Our common stock is listed on the Nasdaq Global Market under the symbol &#8220;CHRS.&#8221; On November&#160;16, 2022, the last reported sale price of our common stock on the Nasdaq Global Market was $7.35 per share.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="margin-top:48pt; text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">The date of this prospectus is November&#160;17, 2022.</font>
        </div>
      </div>
      <hr >
    </div>
    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a><a name="TOC2">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;height:660pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">TABLE OF CONTENTS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <table style="width:456pt;height:220pt;margin-top:10pt;border-collapse: collapse;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; width:440pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#bATP"><font style="letter-spacing:-0.025pt;">ABOUT THIS PROSPECTUS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:0pt 0pt 1pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bATP">1</a></font> <a href="#bATP"></a></td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:440pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#bCNRF"><font style="letter-spacing:-0.025pt;">CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bCNRF">2</a></font> <a href="#bCNRF"></a></td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
          </tr>
          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:440pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#bWYCF"><font style="letter-spacing:-0.025pt;">WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCE </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bWYCF">3</a></font> <a href="#bWYCF"></a></td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:10pt;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:440pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#bTHCO"><font style="letter-spacing:-0.025pt;">THE COMPANY </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bTHCO">5</a></font> <a href="#bTHCO"></a></td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; width:440pt;text-align:left;">
              <div style="white-space:nowrap;">
                <a href="#bRIFA"><font style="letter-spacing:-0.025pt;">RISK FACTORS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bRIFA">6</a></font> <a href="#bRIFA"></a></td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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              <div style="white-space:nowrap;">
                <a href="#bUOP"><font style="letter-spacing:-0.025pt;">USE OF PROCEEDS </font></a>
              </div>
            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bUOP">7</a></font> <a href="#bUOP"></a></td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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          <tr style="line-height:10pt;background-color:#CCEEFF;white-space:nowrap;text-align:center;vertical-align:bottom;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
            <td style="padding:0pt; width:0pt;">&#8203;</td>
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                <a href="#bDOCS"><font style="letter-spacing:-0.025pt;">DESCRIPTION OF CAPITAL STOCK </font></a>
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            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bDOCS">8</a></font> <a href="#bDOCS"></a></td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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              <div style="white-space:nowrap;">
                <a href="#bDODS"><font style="letter-spacing:-0.025pt;">DESCRIPTION OF DEBT SECURITIES </font></a>
              </div>
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            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bDODS">11</a></font> <a href="#bDODS"></a></td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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              <div style="white-space:nowrap;">
                <a href="#bDOOS"><font style="letter-spacing:-0.025pt;">DESCRIPTION OF OTHER SECURITIES </font></a>
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            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:15pt; text-align:right; white-space:nowrap;">
              <font style="letter-spacing:-0.025pt;"><a href="#bDOOS">18</a></font> <a href="#bDOOS"></a></td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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              <div style="white-space:nowrap;">
                <a href="#bDOW"><font style="letter-spacing:-0.025pt;">DESCRIPTION OF WARRANTS </font></a>
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            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
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              <font style="letter-spacing:-0.025pt;"><a href="#bDOW">19</a></font> <a href="#bDOW"></a></td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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                <a href="#bDOU"><font style="letter-spacing:-0.025pt;">DESCRIPTION OF UNITS </font></a>
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            </td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt; width:0.5pt;">&#8203;</td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
            <td style="padding:3.5pt 0pt 1.5pt 0pt; min-width:0pt; text-align:right; ">&#8203;</td>
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              <font style="letter-spacing:-0.025pt;"><a href="#bDOU">20</a></font> <a href="#bDOU"></a></td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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                <a href="#bGLSE"><font style="letter-spacing:-0.025pt;">GLOBAL SECURITIES </font></a>
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              <font style="letter-spacing:-0.025pt;"><a href="#bGLSE">21</a></font> <a href="#bGLSE"></a></td>
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            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
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              <font style="letter-spacing:-0.025pt;"><a href="#bPOD">25</a></font> <a href="#bPOD"></a></td>
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            <td style="padding:0pt; width:0pt;">&#8203;</td>
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                <a href="#bLEMA"><font style="letter-spacing:-0.025pt;">LEGAL MATTERS </font></a>
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              <font style="letter-spacing:-0.025pt;"><a href="#bLEMA">27</a></font> <a href="#bLEMA"></a></td>
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              <font style="letter-spacing:-0.025pt;"><a href="#bEXP">27</a></font>
            </td>
            <td style="padding:0pt;padding-left:1.945pt;width:0pt;">&#8203;</td>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bATP">&#8203;</a>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">ABOUT THIS PROSPECTUS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">This prospectus is part of a registration statement that we filed with the U.S. Securities and Exchange Commission, or the SEC, using a &#8220;shelf&#8221; registration process. By using a shelf registration statement, we may sell securities from time to time and in one or more offerings up to a total dollar amount of $150.0&#160;million as described in this prospectus. Each time that we offer and sell securities, we will provide a prospectus supplement to this prospectus that contains specific information about the securities being offered and sold and the specific terms of that offering. We may also authorize one or more free writing prospectuses to be provided to you that may contain material information relating to these offerings. The prospectus supplement or free writing prospectus may also add, update or&#160;change information contained in this prospectus with respect to that offering. If there is any inconsistency between the information in this prospectus and the applicable prospectus supplement or free writing prospectus, you should rely on the prospectus supplement or free writing prospectus, as applicable. Before&#160;purchasing any securities, you should carefully read both this prospectus and the applicable prospectus supplement (and any applicable free writing prospectuses), together with the additional information described under the heading &#8220;Where You Can Find More Information; Incorporation by Reference.&#8221;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We have not authorized anyone to provide you with any information or to make any representations other than those contained in this prospectus, any applicable prospectus supplement or any free writing prospectuses prepared by or on behalf of us or to which we have referred you. We take no responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. We will not make an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. You should assume that the information appearing in this prospectus and the applicable prospectus supplement to this prospectus is accurate only as of the date on its respective cover, that the information appearing in any applicable free writing prospectus is accurate only as of the date of that free writing prospectus, and that any information incorporated by reference is accurate only as of the date of the document incorporated by reference, unless we indicate otherwise. Our business, financial condition, results of operations and prospects may have changed since those dates. This prospectus incorporates by reference, and any prospectus supplement or free writing prospectus may contain and incorporate by reference, market data and industry statistics and forecasts that are based on independent industry publications and other publicly available information. Although we believe these sources are reliable, we do not guarantee the accuracy or completeness of this information and we have not independently verified this information. In addition, the market and industry data and forecasts that may be included or incorporated by reference in this prospectus, any prospectus supplement or any applicable free writing prospectus may involve estimates, assumptions and other risks and uncertainties and are subject to change based on various factors, including those discussed under the heading &#8220;Risk Factors&#8221; contained in this prospectus, the applicable prospectus supplement and any applicable free writing prospectus, and under similar headings in other documents that are incorporated by reference into this prospectus. Accordingly, investors should not place undue reliance on this information.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">When we refer to &#8220;Coherus,&#8221; &#8220;we,&#8221; &#8220;our,&#8221; &#8220;us&#8221; and the &#8220;Company&#8221; in this prospectus, we mean Coherus BioSciences, Inc. and its consolidated subsidiaries, unless otherwise specified. When we refer to &#8220;you,&#8221; we mean the potential holders of the applicable series of securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Coherus BioSciences</font><font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:-0.019pt;">&#174;</font><font style="letter-spacing:-0.025pt;">, our logo and our other trade names, trademarks or service marks appearing in this prospectus are the property of Coherus. This prospectus and the documents incorporated by reference herein also include trademarks, tradenames and service marks that are the property of other organizations. Solely for convenience, our trademarks and tradenames referred to in this prospectus appear without the </font><font style=" position:relative; bottom:4.25pt;font-size:7.5pt;letter-spacing:-0.019pt;">&#174;</font><font style="letter-spacing:-0.025pt;"> and &#8482; symbols, but those references are not intended to indicate, in any way, that we will not assert, to the fullest extent under applicable law, our rights or the right of the applicable licensor to these trademarks and tradenames. </font>
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          <font style="letter-spacing:-0.025pt;">1</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bCNRF">&#8203;</a>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">This prospectus contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained or incorporated by reference in this prospectus other than statements of historical fact, including statements regarding our future operating results and financial position, our ability to develop and commercialize our product candidates, our business strategy and plans, potential acquisitions, market growth and trends, and our objectives for future operations, are forward-looking statements. The words &#8220;believe,&#8221; &#8220;may,&#8221; &#8220;will,&#8221; &#8220;estimate,&#8221; &#8220;continue,&#8221; &#8220;anticipate,&#8221; &#8220;intend,&#8221; &#8220;expect,&#8221; &#8220;could,&#8221; &#8220;would,&#8221; &#8220;project,&#8221; &#8220;plan,&#8221; &#8220;potentially,&#8221; &#8220;preliminary,&#8221; &#8220;likely,&#8221; and similar expressions are intended to identify forward-looking statements. We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy, short-term and long-term business operations and objectives, and financial needs. These forward-looking statements are subject to a number of risks, uncertainties, and assumptions, including the risk factors incorporated herein by reference from our most recent Quarterly Report on Form 10-Q and any subsequent Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q or Current Reports on Form 8-K we file after the date of this prospectus, and all other information contained or incorporated by reference into this prospectus, as updated by our subsequent filings under the Exchange Act and in our other filings with the SEC, that may cause our actual results, performance or achievements to differ materially and adversely from those expressed or implied by the forward-looking statements.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Any forward-looking statements made herein speak only as of the date of this prospectus, and you should not rely on forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, performance, or achievements reflected in the forward-looking statements will be achieved or occur. We undertake no obligation to update any of these forward-looking statements for any reason after the date of prospectus or to conform these statements to actual results or revised expectations. </font>
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          <font style="letter-spacing:-0.025pt;">2</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bWYCF">&#8203;</a>
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        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCE</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Available Information</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We file reports, proxy statements and other information with the SEC. The SEC maintains a web site that contains reports, proxy and information statements and other information about issuers, such as us, who file electronically with the SEC. The address of that website is </font><font style="font-style:italic;">http://www.sec.gov</font><font style="letter-spacing:-0.025pt;">.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Our web site address is </font><font style="font-style:italic;">https://www.coherus.com</font><font style="letter-spacing:-0.025pt;">. The information on our web site, however, is not, and should not be deemed to be, a part of this prospectus. We also use our website as a means of disclosing material non-public information and for complying with our disclosure obligations under Regulation&#160;FD.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">This prospectus and any prospectus supplement are part of a registration statement that we filed with the SEC and do not contain all of the information in the registration statement. The full registration statement may be obtained from the SEC or us, as provided below. Forms of the indenture and other documents establishing the terms of the offered securities are or may be filed as exhibits to the registration statement or documents incorporated by reference in the registration statement. Statements in this prospectus or any prospectus supplement about these documents are summaries and each statement is qualified in all respects by reference to the document to which it refers. You should refer to the actual documents for a more complete description of the relevant matters. You may inspect a copy of the registration statement through the SEC&#8217;s website, as provided above.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Incorporation by Reference</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The SEC&#8217;s rules allow us to &#8220;incorporate by reference&#8221; information into this prospectus, which means that we can disclose important information to you by referring you to another document filed separately with the SEC. The information incorporated by reference is deemed to be part of this prospectus, and subsequent information that we file with the SEC will automatically update and supersede that information. Any statement contained in this prospectus or a previously filed document incorporated by reference will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus, prospectus supplement or a subsequently filed document incorporated by reference modifies or replaces that statement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">This prospectus and any accompanying prospectus supplement incorporate by reference the documents set forth below that have previously been filed with the SEC:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837022001764/chrs-20211231x10k.htm">Our Annual Report on Form 10-K for the year ended December&#160;31, 2021, filed with the SEC on February&#160;23, 2022.</a><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <a style="-sec-extract:exhibit" href="http://www.sec.gov/Archives/edgar/data/1512762/000155837022005048/tmb-20220517xdef14a.htm">The information specifically incorporated by reference into our Annual Report on Form 10-K from our Definitive Proxy Statement on Schedule&#160;14A, filed with the SEC on April&#160;4, 2022.</a><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">Our Quarterly Reports on Form 10-Q for the quarter ended March&#160;31, 2022, filed with the SEC on <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837022007420/chrs-20220331x10q.htm">May&#160;5, 2022,</a> for the quarter ended June&#160;30, 2022, filed with the SEC on <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837022012251/chrs-20220630x10q.htm">August&#160;4, 2022,</a> and for the quarter ended September&#160;30, 2022, filed with the SEC on <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837022016850/chrs-20220930x10q.htm">November&#160;8, 2022.</a></font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">Our Current Reports on Form 8-K filed with the SEC on <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522004051/d231535d8k.htm">January&#160;7, 2022,</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522008717/d282880d8k.htm">January&#160;13, 2022,</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522029787/d298250d8k.htm">February&#160;7, 2022</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522093655/d343517d8k.htm">April&#160;1, 2022,</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837022007404/chrs-20220503x8k.htm">May&#160;5, 2022,</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522146410/d328049d8k.htm">May&#160;10, 2022,</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522150187/d287872d8k.htm">May&#160;13, 2022,</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522156321/d343606d8k.htm">May&#160;20, 2022,</a> <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522242031/d385883d8k.htm">September&#160;9, 2022,</a> and <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522245659/d337325d8k.htm">September&#160;15, 2022,</a> and our Current Report on Form 8-K/A filed on <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000119312522258849/d293967d8ka.htm">October&#160;6, 2022.</a></font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <a style="-sec-extract:exhibit" href="http://www.sec.gov/Archives/edgar/data/1512762/000119312514393922/d814871d8a12b.htm">The description of our Common Stock contained in our registration statement on Form 8-A, filed with the SEC on November&#160;3, 2014, and any amendment or report filed with the SEC for the purpose of updating the description.</a><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">All reports and other documents we subsequently file pursuant to Section&#160;13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, which we refer to as the &#8220;Exchange Act&#8221; in this prospectus, prior to the termination of this offering, including all such documents we may file with the SEC after the date of the initial registration statement and prior to the effectiveness of the registration statement, but excluding any information furnished to, rather than filed with, the SEC, will also be incorporated by reference into this prospectus and deemed to be part of this prospectus from the date of the filing of such reports and documents.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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          <font style="letter-spacing:-0.025pt;">You may request a free copy of any of the documents incorporated by reference in this prospectus by writing or telephoning us at the following address:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">Coherus BioSciences, Inc.</font>
          <br >
          <font style="letter-spacing:-0.025pt;">333 Twin Dolphin Drive, Suite 600</font>
          <br >
          <font style="letter-spacing:-0.025pt;">Redwood City, CA 94065</font>
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          <font style="letter-spacing:-0.025pt;">(650) 649-3530</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">Exhibits to the filings will not be sent, however, unless those exhibits have specifically been incorporated by reference in this prospectus or any accompanying prospectus supplement. </font>
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          <font style="letter-spacing:-0.025pt;">4</font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">THE COMPANY</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We are a commercial-stage biopharmaceutical company focused on the research, development and commercialization of innovative cancer treatments and the commercialization of our portfolio of FDA-approved biosimilars. Our strategy is to build a leading immuno-oncology franchise funded with cash generated through net sales of our diversified portfolio of FDA-approved therapeutics.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">We were incorporated in the State of Delaware in September&#160;2010 under the name BioGenerics,&#160;Inc. We subsequently changed the name of the corporation in April&#160;2012 to Coherus BioSciences, Inc. Our principal executive offices are located at 333 Twin Dolphin Drive, Suite 600, Redwood City, California 94065, and our telephone number is (650) 649-3530. Our website address is https://&#160;www.coherus.com. The information contained in or that can be accessed through our website is not, and should not be deemed to be, part of this prospectus. We also use our website as a means of disclosing material non-public information and for complying with our disclosure obligations under Regulation&#160;FD.</font>
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          <font style="letter-spacing:-0.025pt;">5</font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">RISK FACTORS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Investment in any of our securities offered pursuant to this prospectus and the applicable prospectus supplement involves a high degree of risk. Before deciding whether to invest in our securities, you should carefully consider the risks described under the caption &#8220;Risk Factors&#8221; contained in our most recent Quarterly Report on Form 10-Q and any subsequent Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q or Current Reports on Form 8-K, and all other information contained or incorporated by reference into this prospectus, as updated by our subsequent filings under the Exchange Act, and the risks described under the caption &#8220;Risk Factors&#8221; and other information contained in the applicable prospectus supplement and any applicable free writing prospectus. The occurrence of any of these risks might cause you to lose all or part of your investment in the offered securities. There may be other unknown or unpredictable economic, business, competitive, regulatory or other factors that could have material adverse effects on our future results. Past financial performance may not be a reliable indicator of future performance, and historical trends should not be used to anticipate results or trends in future periods. If any of these risks actually occurs, our business, financial condition, results of operations or cash flow could be seriously harmed. This could cause the trading price of our securities to decline, resulting in a loss of all or part of your investment. Please also carefully read the section entitled &#8220;Cautionary Note Regarding Forward-Looking Statements&#8221; included in our most recent Annual Report on Form 10-K and any subsequent Quarterly Reports on Form 10-Q or Current Reports on Form 8-K. </font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">USE OF PROCEEDS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
          <font style="letter-spacing:-0.025pt;">We intend to use the net proceeds from the sale of the securities as set forth in the applicable prospectus supplement.</font>
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          <font style="letter-spacing:-0.025pt;">7</font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">DESCRIPTION OF CAPITAL STOCK</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. This description is summarized from, and qualified in its entirety by reference to, our amended and restated certificate of incorporation, or certificate of incorporation, and our amended and restated bylaws, or bylaws, both of which have been publicly filed with the SEC. See &#8220;Where You Can Find More Information; Incorporation by Reference.&#8221;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.022pt;">Common Stock</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">General<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The certificate of incorporation authorizes 300,000,000 shares of common stock, $0.0001 par value per share.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Voting Rights<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Each holder of common stock is entitled to one vote for each share on all matters submitted to a vote of the stockholders, including the election of directors. Our common stockholders do not have cumulative voting rights in the election of directors. Accordingly, holders of a majority of the voting shares are able to elect all of the directors.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Dividends<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Subject to preferences that may be applicable to any then outstanding preferred stock, holders of common stock are entitled to receive ratably those dividends, if any, as may be declared from time to time by the board of directors out of legally available funds.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Liquidation<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
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          <font style="letter-spacing:-0.025pt;">In the event of our liquidation, dissolution or winding up, holders of common stock will be entitled to share ratably in the net assets legally available for distribution to stockholders after the payment of all of our debts and other liabilities and the satisfaction of any liquidation preference granted to the holders of any then outstanding shares of preferred stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Rights and Preferences<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Holders of common stock have no preemptive, conversion, subscription, or other rights, and there are no redemption or sinking fund provisions applicable to the common stock. The rights, preferences and privileges of the holders of common stock are subject to, and may be adversely affected by the rights of the holders of shares of any series of preferred stock that we may designate in the future.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Fully Paid and Nonassessable<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
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          <font style="letter-spacing:-0.025pt;">All outstanding shares of common stock are fully paid and non-assessable.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Annual Stockholder Meetings</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The certificate of incorporation and bylaws provide that annual stockholder meetings will be held at a date, place (if any) and time as designated by resolution of the board of directors from time to time. To the extent permitted under applicable law, we may but are not obligated to conduct meetings by remote communications, including by webcast.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.022pt;">Anti-Takeover Effects of Provisions</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Some provisions of Delaware law and the certificate of incorporation and bylaws could make the following transactions difficult: acquisition by means of a tender offer; acquisition by means of a proxy contest or otherwise; or removal of incumbent officers and directors. It is possible that these provisions could make it more difficult to accomplish or could deter transactions that stockholders may otherwise consider to be in their best interest or in the best interests of the company, including transactions that might result in a premium over the market price for shares of common stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">These provisions, summarized below, are expected to discourage coercive takeover practices and inadequate takeover bids. These provisions are also designed to encourage persons seeking to acquire control to first negotiate with our board of directors. We believe that the benefits of protection to the company&#8217;s potential ability to negotiate with the proponent of an unfriendly or unsolicited proposal to </font>
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          <font style="letter-spacing:-0.025pt;">8</font>
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          <font style="letter-spacing:-0.025pt;">acquire or restructure the company outweigh the disadvantages of discouraging these proposals because negotiation of these proposals could result in an improvement of their terms.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Delaware Anti-Takeover Statute<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Section&#160;203 of the DGCL prohibits persons deemed &#8220;interested stockholders&#8221; from engaging in a &#8220;business combination&#8221; with a publicly-held Delaware corporation for three&#160;years following the date these persons become interested stockholders unless the business combination is, or the transaction in which the person became an interested stockholder was, approved in a prescribed manner or another prescribed exception applies. Generally, an &#8220;interested stockholder&#8221; is a person who, together with affiliates and associates, owns, or within three&#160;years prior to the determination of interested stockholder status did own, 15% or more of a corporation&#8217;s voting stock and a &#8220;business combination&#8221; includes a merger, asset or stock sale, or other transaction resulting in a financial benefit to the interested stockholder. The existence of this provision may have an anti-takeover effect with respect to transactions not approved in advance by the board of directors, such as discouraging takeover attempts that might result in a premium over the market price of our common stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Undesignated Preferred Stock<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
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          <font style="letter-spacing:-0.025pt;">Under the certificate of incorporation, our board of directors has the authority, without action by our stockholders, to designate and issue up to 5,000,000 shares of preferred stock, par value $0.0001&#160;per share, in one or more series and to designate the rights, preferences and privileges of each series, any or all of which may be greater than the rights of our common stock. It is not possible to state the actual effect of the issuance of any shares of preferred stock upon the rights of holders of our common stock until our board of directors determines the specific rights of the holders of preferred stock. However, the effects might include, among other things, restricting dividends on the common stock, diluting the voting power of the common stock, impairing the liquidation rights of the common stock and delaying or preventing a change in control of our common stock without further action by our stockholders and may adversely affect the market price of our common stock. As of September&#160;30, 2022, no shares of our preferred stock were outstanding.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Special Stockholder Meetings<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The bylaws provide that a special meeting of stockholders may be called by our corporate secretary only at the direction of the board of directors pursuant to a resolution adopted by a majority of the board of directors.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Requirements for Advance Notification of Stockholder Nominations and Proposals<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The bylaws set forth advance notice procedures with respect to stockholder proposals and the nomination of candidates for election as directors, other than nominations made by or at the direction of the board of directors or a committee of the board of directors.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;font-style:italic;font-weight:bold;">Composition of the Board of Directors; Election and Removal of Directors; Filling Vacancies </div>
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          <font style="letter-spacing:-0.025pt;">Our board of directors is divided into three classes. The directors in each class will serve for a three-year term, one class being elected each year by our stockholders, with staggered three-year terms. Only one class of directors will be elected at each annual meeting of our stockholders, with the other classes continuing for the remainder of their respective three-year terms. Furthermore, the size of the board of directors shall be determined from time to time exclusively by the board of directors pursuant to a resolution adopted by the board of directors, provided the board of directors may not consist of fewer than one member. In addition, a vote of the majority of all the then outstanding shares of voting stock is required for removal of a director with cause and not less than sixty-six and two-thirds&#160;percent (66&#160;</font><font style=" position:relative; bottom:2.66pt;font-size:7pt;letter-spacing:-0.018pt;">2</font><font style="letter-spacing:-0.025pt;">&#8725;</font><font style="font-size:7pt;letter-spacing:-0.018pt;">3</font><font style="letter-spacing:-0.025pt;">%) of all the then outstanding shares of voting stock is required for removal of a director without cause. Furthermore, any vacancy on the board of directors, including a vacancy resulting from an increase in the size of the board, may be filled only by a majority vote of the board of directors then in office, although less than a quorum, or by a sole remaining director. This system of electing and removing directors and filling vacancies may tend to discourage a third party from making a tender offer or otherwise attempting to obtain control of the company, because it generally makes it more difficult for stockholders to replace a majority of the directors.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Amendment of the Certificate of Incorporation and Bylaws<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
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          <font style="letter-spacing:-0.025pt;">Amendment of any of the above anti-takeover provisions set forth in the certificate of incorporation, except for the provision making it possible for the board to issue &#8220;blank check&#8221; preferred stock, would </font>
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          <font style="letter-spacing:-0.025pt;">9</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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          <font style="letter-spacing:-0.025pt;">require approval by holders of at least sixty-six and two-thirds&#160;percent (66 </font><font style=" position:relative; bottom:2.66pt;font-size:7pt;letter-spacing:-0.018pt;">2</font><font style="letter-spacing:-0.025pt;">&#8725;</font><font style="font-size:7pt;letter-spacing:-0.018pt;">3</font><font style="letter-spacing:-0.025pt;">%) of the voting power of the then outstanding voting stock. Subject to limitations set forth in the bylaws or the certificate of incorporation, the board is expressly empowered to adopt, amend or repeal the bylaws. Stockholders shall have the power to amend the bylaws provided that any such amendment would require approval by holders of at least sixty-six and two-thirds&#160;percent (66 </font><font style=" position:relative; bottom:2.66pt;font-size:7pt;letter-spacing:-0.018pt;">2</font><font style="letter-spacing:-0.025pt;">&#8725;</font><font style="font-size:7pt;letter-spacing:-0.018pt;">3</font><font style="letter-spacing:-0.025pt;">%) of the voting power of the then outstanding voting stock.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The provisions of the DGCL, the certificate of incorporation and bylaws could have the effect of discouraging others from attempting hostile takeovers and, as a consequence, they may also inhibit temporary fluctuations in the market price of our common stock that often result from actual or rumored hostile takeover attempts. These provisions may also have the effect of preventing changes in the management of our company. It is possible that these provisions could make it more difficult to accomplish transactions that stockholders may otherwise deem to be in their best interests.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.022pt;">Limitations of Liability and Indemnification Matters</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">The certificate of incorporation contains provisions that limit the liability of the directors and officers for monetary damages to the fullest extent permitted by Delaware law. Consequently, directors and officers are not personally liable to us or our stockholders for monetary damages for any breach of fiduciary duties as directors, except liability for:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">any breach of the director&#8217;s or officer&#8217;s duty of loyalty to us or our stockholders;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">unlawful payments of dividends or unlawful stock repurchases or redemptions as provided in Section&#160;174 of the DGCL; or</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:-0.025pt;">any transaction from which the director or officer derived an improper personal benefit.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">Each of the certificate of incorporation and bylaws provides that we are required to indemnify the directors and officers, in each case to the fullest extent permitted by Delaware law. The bylaws also obligate us to advance expenses incurred by a director or officer in advance of the final disposition of any action or proceeding, and permit us to secure insurance on behalf of any officer, director, employee or other agent for any liability arising out of his or her actions in that capacity regardless of whether we would otherwise be permitted to indemnify him or her under Delaware law. We have entered into agreements to indemnify the directors, executive officers and other employees as determined by the board of directors. With specified exceptions, these agreements provide for indemnification for related expenses including, among other things, attorneys&#8217; fees, judgments, fines and settlement amounts incurred by any of these individuals in any action or proceeding to the fullest extent permitted by applicable law. We believe that these bylaw provisions and indemnification agreements are necessary to attract and retain qualified persons as directors and officers. We also maintain directors&#8217; and officers&#8217; liability insurance.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The limitation of liability and indemnification provisions in the certificate of incorporation and bylaws may discourage stockholders from bringing a lawsuit against the directors and officers for breach of their fiduciary duty. They may also reduce the likelihood of derivative litigation against the directors and officers, even though an action, if successful, might benefit us and our stockholders. Furthermore, a stockholder&#8217;s investment may be adversely affected to the extent that we pay the costs of settlement and damage.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.022pt;">Stock Exchange Listing</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">The shares of common stock are listed on Nasdaq under the symbol &#8220;CHRS.&#8221;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.022pt;">No Sinking Fund</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">The shares of common stock have no sinking fund provisions.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.022pt;">Transfer Agent and Registrar</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">The transfer agent and registrar for our common stock is Equiniti Trust Company Shareowner Services. The transfer agent and registrar&#8217;s address is Equiniti Trust Company Shareowner Services, P.O. Box 64854, St. Paul, MN 55164-0854. </font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bDODS">&#8203;</a>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">DESCRIPTION OF DEBT SECURITIES</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">The following description, together with the additional information we include in any applicable prospectus supplement or free writing prospectus, summarizes certain general terms and provisions of the debt securities that we may offer under this prospectus. When we offer to sell a particular series of debt securities, we will describe the specific terms of the series in a supplement to this prospectus. We will also indicate in the supplement to what extent the general terms and provisions described in this prospectus apply to a particular series of debt securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We may issue debt securities either separately, or together with, or upon the conversion or exercise of or in exchange for, other securities described in this prospectus. Debt securities may be our senior, senior subordinated or subordinated obligations and, unless otherwise specified in a supplement to this prospectus, the debt securities will be our direct, unsecured obligations and may be issued in one or more series.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The debt securities will be issued under an indenture between us and a trustee. We have summarized select portions of the indenture below. The summary is not complete. The form of the indenture has been filed as an exhibit to the registration statement and you should read the indenture for provisions that may be important to you. In the summary below, we have included references to the section numbers of the indenture so that you can easily locate these provisions. Capitalized terms used in the summary and not defined herein have the meanings specified in the indenture.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">As used in this section only, &#8220;Coherus,&#8221; &#8220;we,&#8221; &#8220;our&#8221; or &#8220;us&#8221; refer to Coherus BioSciences, Inc. excluding our subsidiaries, unless expressly stated or the context otherwise requires.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">General</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">The terms of each series of debt securities will be established by or pursuant to a resolution of our board of directors and set forth or determined in the manner provided in a resolution of our board of directors, in an officer&#8217;s certificate or by a supplemental indenture. (Section&#160;2.2) The particular terms of each series of debt securities will be described in a prospectus supplement relating to such series (including any pricing supplement or term sheet).</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">We can issue an unlimited amount of debt securities under the indenture that may be in one or more series with the same or various maturities, at par, at a premium, or at a discount. (Section&#160;2.1) We will set forth in a prospectus supplement (including any pricing supplement or term sheet) relating to any series of debt securities being offered, the aggregate principal amount and the following terms of the debt securities, if applicable:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">the title and ranking of the debt securities (including the terms of any subordination provisions);</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">the price or prices (expressed as a&#160;percentage of the principal amount) at which we will sell the debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">any limit on the aggregate principal amount of the debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">the date or dates on which the principal of the securities of the series is payable;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">the rate or rates (which may be fixed or variable) per annum or the method used to determine the rate or rates (including any commodity, commodity index, stock exchange index or financial index) at which the debt securities will bear interest, the date or dates from which interest will accrue, the date or dates on which interest will commence and be payable and any regular record date for the interest payable on any interest payment date;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:1.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:1.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the place or places where principal of, and interest, if any, on the debt securities will be payable (and the method of such payment), where the securities of such series may be surrendered for registration of transfer or exchange, and where notices and demands to us in respect of the debt securities may be delivered;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:1.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:1.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the period or periods within which, the price or prices at which and the terms and conditions upon which we may redeem the debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:1.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">any obligation we have to redeem or purchase the debt securities pursuant to any sinking fund or analogous provisions or at the option of a holder of debt securities and the period or periods within </font>
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          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">11</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-left:20pt; width:436pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">which, the price or prices at which and in the terms and conditions upon which securities of the series shall be redeemed or purchased, in whole or in part, pursuant to such obligation;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.69pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.69pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the dates on which and the price or prices at which we will repurchase debt securities at the option of the holders of debt securities and other detailed terms and provisions of these repurchase obligations;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.7pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.7pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the denominations in which the debt securities will be issued, if other than denominations of $1,000 and any integral multiple thereof;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.69pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.69pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">whether the debt securities will be issued in the form of certificated debt securities or global debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.8pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.8pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the portion of principal amount of the debt securities payable upon declaration of acceleration of the maturity date, if other than the principal amount;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.79pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.79pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the currency of denomination of the debt securities, which may be United States Dollars or any foreign currency, and if such currency of denomination is a composite currency, the agency or organization, if any, responsible for overseeing such composite currency;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.8pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.8pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the designation of the currency, currencies or currency&#160;units in which payment of principal of, premium and interest on the debt securities will be made;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.8pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.8pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">if payments of principal of, premium or interest on the debt securities will be made in one or more currencies or currency&#160;units other than that or those in which the debt securities are denominated, the manner in which the exchange rate with respect to these payments will be determined;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.79pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.79pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the manner in which the amounts of payment of principal of, premium, if any, or interest on the debt securities will be determined, if these amounts may be determined by reference to an index based on a currency or currencies or by reference to a commodity, commodity index, stock exchange index or financial index;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.79pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">any provisions relating to any security provided for the debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.8pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">any addition to, deletion of or change in the Events of Default described in this prospectus or in the indenture with respect to the debt securities and any change in the acceleration provisions described in this prospectus or in the indenture with respect to the debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.79pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.79pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">any addition to, deletion of or change in the covenants described in this prospectus or in the indenture with respect to the debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.8pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.8pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">any depositaries, interest rate calculation agents, exchange rate calculation agents or other agents with respect to the debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.79pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.79pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the provisions, if any, relating to conversion or exchange of any debt securities of such series, including if applicable, the conversion or exchange price and period, provisions as to whether conversion or exchange will be mandatory, the events requiring an adjustment of the conversion or exchange price and provisions affecting conversion or exchange;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.79pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">any other terms of the debt securities, which may supplement, modify or delete any provision of the indenture as it applies to that series, including any terms that may be required under applicable law or regulations or advisable in connection with the marketing of the securities; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.8pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">whether any of our direct or indirect subsidiaries will guarantee the debt securities of that series, including the terms of subordination, if any, of such guarantees. (Section&#160;2.2)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We may issue debt securities that provide for an amount less than their stated principal amount to be due and payable upon declaration of acceleration of their maturity pursuant to the terms of the indenture. We will provide you with information on the federal income tax considerations and other special considerations applicable to any of these debt securities in the applicable prospectus supplement. </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">If we denominate the purchase price of any of the debt securities in a foreign currency or currencies or a foreign currency unit or&#160;units, or if the principal of and any premium and interest on any series of debt securities is payable in a foreign currency or currencies or a foreign currency unit or&#160;units, we will provide you with information on the restrictions, elections, general tax considerations, specific terms and other information with respect to that issue of debt securities and such foreign currency or currencies or foreign currency unit or&#160;units in the applicable prospectus supplement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:-0.025pt;">12</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:-0.022pt;">Transfer and Exchange</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Each debt security will be represented by either one or more global securities registered in the name of The Depository Trust Company, or the Depositary, or a nominee of the Depositary (we will refer to any debt security represented by a global debt security as a &#8220;book-entry debt security&#8221;), or a certificate issued in definitive registered form (we will refer to any debt security represented by a certificated security as a &#8220;certificated debt security&#8221;) as set forth in the applicable prospectus supplement. Except as set forth under the heading &#8220;Global Debt Securities and Book-Entry System&#8221; below, book-entry debt securities will not be issuable in certificated form.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Certificated Debt Securities. You may transfer or exchange certificated debt securities at any office we maintain for this purpose in accordance with the terms of the indenture. (Section&#160;2.4) No service charge will be made for any transfer or exchange of certificated debt securities, but we may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection with a transfer or exchange. (Section&#160;2.7)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">You may effect the transfer of certificated debt securities and the right to receive the principal of, premium and interest on certificated debt securities only by surrendering the certificate representing those certificated debt securities and either reissuance by us or the trustee of the certificate to the new holder or the issuance by us or the trustee of a new certificate to the new holder.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Global Debt Securities and Book-Entry System. Each global debt security representing book-entry debt securities will be deposited with, or on behalf of, the Depositary, and registered in the name of the Depositary or a nominee of the Depositary. Please see &#8220;Global Securities.&#8221;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Covenants</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We will set forth in the applicable prospectus supplement any restrictive covenants applicable to any issue of debt securities. (Article&#160;IV)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">No Protection in the Event of a Change of Control</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Unless we state otherwise in the applicable prospectus supplement, the debt securities will not contain any provisions which may afford holders of the debt securities protection in the event we have a change in control or in the event of a highly leveraged transaction (whether or not such transaction results in a change in control) which could adversely affect holders of debt securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Consolidation, Merger and Sale of Assets</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We may not consolidate with or merge with or into, or convey, transfer or lease all or substantially all of our properties and assets to any person, or a successor person, unless:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">we are the surviving entity or the successor person (if other than Coherus) is a corporation, partnership, trust or other entity organized and validly existing under the laws of any U.S. domestic jurisdiction and expressly assumes our obligations on the debt securities and under the indenture; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">immediately after giving effect to the transaction, no Default or Event of Default, shall have occurred and be continuing.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Notwithstanding the above, any of our subsidiaries may consolidate with, merge into or transfer all or part of its properties to us. (Section&#160;5.1)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Events of Default</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#8220;Event of Default&#8221; means with respect to any series of debt securities, any of the following:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">default in the payment of any interest upon any debt security of that series when it becomes due and payable, and continuance of such default for a period of 30&#160;days (unless the entire amount of the payment is deposited by us with the trustee or with a paying agent prior to the expiration of the 30-day period);</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">default in the payment of principal of any security of that series at its maturity;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">13</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      </div>
      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">default in the performance or breach of any other covenant or warranty by us in the indenture (other than a covenant or warranty that has been included in the indenture solely for the benefit of a series of debt securities other than that series), which default continues uncured for a period of 60&#160;days after we receive written notice from the trustee or Coherus and the trustee receive written notice from the holders of not less than 25% in principal amount of the outstanding debt securities of that series as provided in the indenture;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">certain voluntary or involuntary events of bankruptcy, insolvency or reorganization of Coherus;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">any other Event of Default provided with respect to debt securities of that series that is described in the applicable prospectus supplement. (Section&#160;6.1)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">No Event of Default with respect to a particular series of debt securities (except as to certain events of bankruptcy, insolvency or reorganization) necessarily constitutes an Event of Default with respect to any other series of debt securities. (Section&#160;6.1) The occurrence of certain Events of Default or an acceleration under the indenture may constitute an event of default under certain indebtedness of ours or our subsidiaries outstanding from time to time.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We will provide the trustee written notice of any Default or Event of Default within 30&#160;days of becoming aware of the occurrence of such Default or Event of Default, which notice will describe in reasonable detail the status of such Default or Event of Default and what action we are taking or propose to take in respect thereof. (Section&#160;6.1)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">If an Event of Default with respect to debt securities of any series at the time outstanding occurs and is continuing, then the trustee or the holders of not less than 25% in principal amount of the outstanding debt securities of that series may, by a notice in writing to us (and to the trustee if given by the holders), declare to be due and payable immediately the principal of (or, if the debt securities of that series are discount securities, that portion of the principal amount as may be specified in the terms of that series) and accrued and unpaid interest, if any, on all debt securities of that series. In the case of an Event of Default resulting from certain events of bankruptcy, insolvency or reorganization, the principal (or such specified amount) of and accrued and unpaid interest, if any, on all outstanding debt securities will become and be immediately due and payable without any declaration or other act on the part of the trustee or any holder of outstanding debt securities. At any time after a declaration of acceleration with respect to debt securities of any series has been made, but before a judgment or decree for payment of the money due has been obtained by the trustee, the holders of a majority in principal amount of the outstanding debt securities of that series may rescind and annul the acceleration if all Events of Default, other than the non-payment of accelerated principal and interest, if any, with respect to debt securities of that series, have been cured or waived as provided in the indenture. (Section&#160;6.2) We refer you to the prospectus supplement relating to any series of debt securities that are discount securities for the particular provisions relating to acceleration of a portion of the principal amount of such discount securities upon the occurrence of an Event of Default.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The indenture provides that the trustee may refuse to perform any duty or exercise any of its rights or powers under the indenture unless the trustee receives indemnity satisfactory to it against any cost, liability or expense which might be incurred by it in performing such duty or exercising such right or power. (Section&#160;7.1(e)) Subject to certain rights of the trustee, the holders of a majority in principal amount of the outstanding debt securities of any series will have the right to direct the time, method and place of conducting any proceeding for any remedy available to the trustee or exercising any trust or power conferred on the trustee with respect to the debt securities of that series. (Section&#160;6.12)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">No holder of any debt security of any series will have any right to institute any proceeding, judicial or otherwise, with respect to the indenture or for the appointment of a receiver or trustee, or for any remedy under the indenture, unless:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">that holder has previously given to the trustee written notice of a continuing Event of Default with respect to debt securities of that series; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">the holders of not less than 25% in principal amount of the outstanding debt securities of that series have made written request, and offered indemnity or security satisfactory to the trustee, to the trustee to institute the proceeding as trustee, and the trustee has not received from the holders </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">14</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-left:20pt; width:436pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">of not less than a majority in principal amount of the outstanding debt securities of that series a direction inconsistent with that request and has failed to institute the proceeding within 60&#160;days. (Section&#160;6.7)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Notwithstanding any other provision in the indenture, the holder of any debt security will have an absolute and unconditional right to receive payment of the principal of, premium and any interest on that debt security on or after the due dates expressed in that debt security and to institute suit for the enforcement of payment. (Section&#160;6.8)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The indenture requires us, within 120&#160;days after the end of our fiscal year, to furnish to the trustee a statement as to compliance with the indenture. (Section&#160;4.3) If a Default or Event of Default occurs and is continuing with respect to the securities of any series and if it is known to a responsible officer of the trustee, the trustee shall mail to each Securityholder of the securities of that series notice of a Default or Event of Default within 90&#160;days after it occurs or, if later, after a responsible officer of the trustee has knowledge of such Default or Event of Default. The indenture provides that the trustee may withhold notice to the holders of debt securities of any series of any Default or Event of Default (except in payment on any debt securities of that series) with respect to debt securities of that series if the trustee determines in good faith that withholding notice is in the interest of the holders of those debt securities. (Section&#160;7.5)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Modification and Waiver</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We and the trustee may modify, amend or supplement the indenture or the debt securities of any series without the consent of any holder of any debt security:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2.2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to cure any ambiguity, defect or inconsistency;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to comply with covenants in the indenture described above under the heading &#8220;Consolidation, Merger and Sale of Assets&#8221;;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to provide for uncertificated securities in addition to or in place of certificated securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.19pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.19pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to add guarantees with respect to debt securities of any series or secure debt securities of any series;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to surrender any of our rights or powers under the indenture;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to add covenants or events of default for the benefit of the holders of debt securities of any series;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to comply with the applicable procedures of the applicable depositary;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to make any change that does not adversely affect the rights of any holder of debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to provide for the issuance of and establish the form and terms and conditions of debt securities of any series as permitted by the indenture;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">to effect the appointment of a successor trustee with respect to the debt securities of any series and to add to or change any of the provisions of the indenture to provide for or facilitate administration by more than one trustee; or</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">to comply with requirements of the SEC in order to effect or maintain the qualification of the indenture under the Trust Indenture Act. (Section&#160;9.1)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:-0.025pt;">We may also modify and amend the indenture with the consent of the holders of at least a majority in principal amount of the outstanding debt securities of each series affected by the modifications or amendments. We may not make any modification or amendment without the consent of the holders of each affected debt security then outstanding if that amendment will:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">reduce the amount of debt securities whose holders must consent to an amendment, supplement or waiver;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">reduce the rate of or extend the time for payment of interest (including default interest) on any debt security;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2.1pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">reduce the principal of or premium on or change the fixed maturity of any debt security or reduce the amount of, or postpone the date fixed for, the payment of any sinking fund or analogous obligation with respect to any series of debt securities;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2.1pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">reduce the principal amount of discount securities payable upon acceleration of maturity;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:-0.025pt;">15</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-bottom:2pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">waive a default in the payment of the principal of, premium or interest on any debt security (except a rescission of acceleration of the debt securities of any series by the holders of at least a majority in aggregate principal amount of the then outstanding debt securities of that series and a waiver of the payment default that resulted from such acceleration);</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">make the principal of or premium or interest on any debt security payable in currency other than that stated in the debt security;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">make any change to certain provisions of the indenture relating to, among other things, the right of holders of debt securities to receive payment of the principal of, premium and interest on those debt securities and to institute suit for the enforcement of any such payment and to waivers or amendments; or</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">waive a redemption payment with respect to any debt security. (Section&#160;9.3)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Except for certain specified provisions, the holders of at least a majority in principal amount of the outstanding debt securities of any series may on behalf of the holders of all debt securities of that series waive our compliance with provisions of the indenture. (Section&#160;9.2) The holders of a majority in principal amount of the outstanding debt securities of any series may on behalf of the holders of all the debt securities of such series waive any past default under the indenture with respect to that series and its consequences, except a default in the payment of the principal of, premium or any interest on any debt security of that series; provided, however, that the holders of a majority in principal amount of the outstanding debt securities of any series may rescind an acceleration and its consequences, including any related payment default that resulted from the acceleration. (Section&#160;6.13)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Defeasance of Debt Securities and Certain Covenants in Certain Circumstances</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="font-style:italic;">Legal Defeasance</font><font style="letter-spacing:-0.025pt;">.&nbsp;&nbsp;&nbsp;The indenture provides that, unless otherwise provided by the terms of the applicable series of debt securities, we may be discharged from any and all obligations in respect of the debt securities of any series (subject to certain exceptions). We will be so discharged upon the irrevocable deposit with the trustee, in trust, of money and/or U.S. government obligations or, in the case of debt securities denominated in a single currency other than U.S. Dollars, government obligations of the government that issued or caused to be issued such currency, that, through the payment of interest and principal in accordance with their terms, will provide money or U.S. government obligations in an amount sufficient in the opinion of a nationally recognized firm of independent public accountants or investment bank to pay and discharge each installment of principal, premium and interest on and any mandatory sinking fund payments in respect of the debt securities of that series on the stated maturity of those payments in accordance with the terms of the indenture and those debt securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">This discharge may occur only if, among other things, we have delivered to the trustee an opinion of counsel stating that we have received from, or there has been published by, the United States Internal Revenue Service a ruling or, since the date of execution of the indenture, there has been a change in the applicable United States federal income tax law, in either case to the effect that, and based thereon such opinion shall confirm that, the holders of the debt securities of that series will not recognize income, gain or loss for United States federal income tax purposes as a result of the deposit, defeasance and discharge and will be subject to United States federal income tax on the same amounts and in the same manner and at the same times as would have been the case if the deposit, defeasance and discharge had not occurred. (Section&#160;8.3)</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="font-style:italic;">Defeasance of Certain Covenants</font><font style="letter-spacing:-0.025pt;">.&nbsp;&nbsp;&nbsp;The indenture provides that, unless otherwise provided by the terms of the applicable series of debt securities, upon compliance with certain conditions:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">we may omit to comply with the covenant described under the heading &#8220;Consolidation, Merger and Sale of Assets&#8221; and certain other covenants set forth in the indenture, as well as any additional covenants which may be set forth in the applicable prospectus supplement; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">any omission to comply with those covenants will not constitute a Default or an Event of Default with respect to the debt securities of that series, or covenant defeasance. </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:-0.025pt;">16</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-bottom:72pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-left:20pt; width:436pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The conditions include:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">depositing with the trustee money and/or U.S. government obligations or, in the case of debt securities denominated in a single currency other than U.S. Dollars, government obligations of the government that issued or caused to be issued such currency, that, through the payment of interest and principal in accordance with their terms, will provide money in an amount sufficient in the opinion of a nationally recognized firm of independent public accountants or investment bank to pay and discharge each installment of principal of, premium and interest on and any mandatory sinking fund payments in respect of the debt securities of that series on the stated maturity of those payments in accordance with the terms of the indenture and those debt securities; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">delivering to the trustee an opinion of counsel to the effect that the holders of the debt securities of that series will not recognize income, gain or loss for United States federal income tax purposes as a result of the deposit and related covenant defeasance and will be subject to United States federal income tax on the same amounts and in the same manner and at the same times as would have been the case if the deposit and related covenant defeasance had not occurred. (Section&#160;8.4) </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">No Personal Liability of Directors, Officers, Employees or Securityholders</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">None of our past, present or future directors, officers, employees or securityholders, as such, will have any liability for any of our obligations under the debt securities or the indenture or for any claim based on, or in respect or by reason of, such obligations or their creation. By accepting a debt security, each holder waives and releases all such liability. This waiver and release is part of the consideration for the issue of the debt securities. However, this waiver and release may not be effective to waive liabilities under U.S. federal securities laws, and it is the view of the SEC that such a waiver is against public policy.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Governing Law</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The indenture and the debt securities, including any claim or controversy arising out of or relating to the indenture or the securities, will be governed by the laws of the State of New York.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The indenture will provide that we, the trustee and the holders of the debt securities (by their acceptance of the debt securities) irrevocably waive, to the fullest extent permitted by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to the indenture, the debt securities or the transactions contemplated thereby.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The indenture will provide that any legal suit, action or proceeding arising out of or based upon the indenture or the transactions contemplated thereby may be instituted in the federal courts of the United States of America located in the City of New York or the courts of the State of New York in each case located in the City of New York, and we, the trustee and the holder of the debt securities (by their acceptance of the debt securities) irrevocably submit to the non-exclusive jurisdiction of such courts in any such suit, action or proceeding. The indenture will further provide that service of any process, summons, notice or document by mail (to the extent allowed under any applicable statute or rule of court) to such party&#8217;s address set forth in the indenture will be effective service of process for any suit, action or other proceeding brought in any such court. The indenture will further provide that we, the trustee and the holders of the debt securities (by their acceptance of the debt securities) irrevocably and unconditionally waive any objection to the laying of venue of any suit, action or other proceeding in the courts specified above and irrevocably and unconditionally waive and agree not to plead or claim any such suit, action or other proceeding has been brought in an inconvenient forum. (Section&#160;10.10) </font>
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      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
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          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">17</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bDOOS">&#8203;</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">DESCRIPTION OF OTHER SECURITIES</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
          <font style="letter-spacing:-0.025pt;">We will set forth in the applicable prospectus supplement a description of any warrants or&#160;units issued by us that may be offered and sold pursuant to this prospectus. </font>
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          <font style="letter-spacing:-0.025pt;">&#160;</font>
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        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
          <font style="letter-spacing:-0.025pt;">18</font>
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      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bDOW">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">DESCRIPTION OF WARRANTS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:6pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We may issue warrants for the purchase of shares of our common stock or preferred stock or of debt securities. We may issue warrants independently or together with other securities, and the warrants may be attached to or separate from any offered securities. Each series of warrants will be issued under a separate warrant agreement to be entered into between us and the investors or a warrant agent. The following summary of material provisions of the warrants and warrant agreements are subject to, and qualified in their entirety by reference to, all the provisions of the warrant agreement and warrant certificate applicable to a particular series of warrants. The terms of any warrants offered under a prospectus supplement may differ from the terms described below. We urge you to read the applicable prospectus supplement and any related free writing prospectus, as well as the complete warrant agreements and warrant certificates that contain the terms of the warrants.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The particular terms of any issue of warrants will be described in the prospectus supplement relating to the issue. Those terms may include:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the number of shares of common stock or preferred stock purchasable upon the exercise of warrants to purchase such shares and the price at which such number of shares may be purchased upon such exercise;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the designation, stated value and terms (including, without limitation, liquidation, dividend, conversion and voting rights) of the series of preferred stock purchasable upon exercise of warrants to purchase preferred stock;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the principal amount of debt securities that may be purchased upon exercise of a debt warrant and the exercise price for the warrants, which may be payable in cash, securities or other property;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the date, if any, on and after which the warrants and the related debt securities, preferred stock or common stock will be separately transferable;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the terms of any rights to redeem or call the warrants;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the date on which the right to exercise the warrants will commence and the date on which the right will expire;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">United States Federal income tax consequences applicable to the warrants; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">any additional terms of the warrants, including terms, procedures, and limitations relating to the exchange, exercise and settlement of the warrants.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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          <font style="letter-spacing:-0.025pt;">Holders of equity warrants will not be entitled:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">to vote, consent or receive dividends;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">receive notice as shareholders with respect to any meeting of shareholders for the election of our directors or any other matter; or</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">exercise any rights as shareholders of Coherus.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Each warrant will entitle its holder to purchase the principal amount of debt securities or the number of shares of preferred stock or common stock at the exercise price set forth in, or calculable as set forth in, the applicable prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement, holders of the warrants may exercise the warrants at any time up to the specified time on the expiration date that we set forth in the applicable prospectus supplement. After the close of business on the expiration date, unexercised warrants will become void.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">A holder of warrant certificates may exchange them for new warrant certificates of different denominations, present them for registration of transfer and exercise them at the corporate trust office of the warrant agent or any other office indicated in the applicable prospectus supplement. Until any warrants to purchase debt securities are exercised, the holder of the warrants will not have any rights of holders of the debt securities that can be purchased upon exercise, including any rights to receive payments of principal, premium or interest on the underlying debt securities or to enforce covenants in the applicable indenture. Until any warrants to purchase common stock or preferred stock are exercised, the holders of the warrants will not have any rights of holders of the underlying common stock or preferred stock, including any rights to receive dividends or payments upon any liquidation, dissolution or winding up on the common stock or preferred stock, if any. </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">19</font>
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      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bDOU">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:294pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">DESCRIPTION OF UNITS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We may issue&#160;units consisting of any combination of the other types of securities offered under this prospectus in one or more series. We may evidence each series of&#160;units by unit certificates that we will issue under a separate agreement. We may enter into unit agreements with a unit agent. Each unit agent will be a bank or trust company that we select. We will indicate the name and address of the unit agent in the applicable prospectus supplement relating to a particular series of&#160;units.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The following description, together with the additional information included in any applicable prospectus supplement, summarizes the general features of the&#160;units that we may offer under this prospectus. You should read any prospectus supplement and any free writing prospectus that we may authorize to be provided to you related to the series of&#160;units being offered, as well as the complete unit agreements that contain the terms of the&#160;units. Specific unit agreements will contain additional important terms and provisions and we will file as an exhibit to the registration statement of which this prospectus is a part, or will incorporate by reference from another report that we file with the SEC, the form of each unit agreement relating to&#160;units offered under this prospectus.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">If we offer any&#160;units, certain terms of that series of&#160;units will be described in the applicable prospectus supplement, including, without limitation, the following, as applicable:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the title of the series of&#160;units;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
          <br >
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">identification and description of the separate constituent securities comprising the&#160;units;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        </div>
        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the price or prices at which the&#160;units will be issued;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        </div>
        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">the date, if any, on and after which the constituent securities comprising the&#160;units will be separately transferable;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        </div>
        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">a discussion of certain United States federal income tax considerations applicable to the&#160;units; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">any other terms of the&#160;units and their constituent securities.</font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">20</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bGLSE">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">GLOBAL SECURITIES</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-top:12pt; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="letter-spacing:-0.022pt;">Book-Entry, Delivery and Form</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:4pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Unless we indicate differently in any applicable prospectus supplement or free writing prospectus, the securities initially will be issued in book-entry form and represented by one or more global notes or global securities, or, collectively, global securities. The global securities will be deposited with, or on behalf of, The Depository Trust Company, New York, New York, as depositary, or DTC, and registered in the name of Cede &amp; Co., the nominee of DTC. Unless and until it is exchanged for individual certificates evidencing securities under the limited circumstances described below, a global security may not be transferred except as a whole by the depositary to its nominee or by the nominee to the depositary, or by the depositary or its nominee to a successor depositary or to a nominee of the successor depositary. </font>
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        <div style="margin-left:20pt; margin-top:8pt; width:436pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">DTC has advised us that it is:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:1.71pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:1.71pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">a limited-purpose trust company organized under the New York Banking Law;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:1.7pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">a &#8220;banking organization&#8221; within the meaning of the New York Banking Law;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:1.7pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">a member of the Federal Reserve System;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:1.7pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:1.7pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">a &#8220;clearing corporation&#8221; within the meaning of the New York Uniform Commercial Code; and</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:1.7pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <font style="letter-spacing:-0.025pt;">a &#8220;clearing agency&#8221; registered pursuant to the provisions of Section&#160;17A of the Exchange Act.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">DTC holds securities that its participants deposit with DTC. DTC also facilitates the settlement among its participants of securities transactions, such as transfers and pledges, in deposited securities through electronic computerized book-entry changes in participants&#8217; accounts, thereby eliminating the need for physical movement of securities certificates. &#8220;Direct participants&#8221; in DTC include securities brokers and dealers, including underwriters, banks, trust companies, clearing corporations and other organizations. DTC is a wholly-owned subsidiary of The Depository Trust &amp; Clearing Corporation, or DTCC. DTCC is the holding company for DTC, National Securities Clearing Corporation and Fixed Income Clearing Corporation, all of which are registered clearing agencies. DTCC is owned by the users of its regulated subsidiaries. Access to the DTC system is also available to others, which we sometimes refer to as indirect participants, that clear through or maintain a custodial relationship with a direct participant, either directly or indirectly. The rules applicable to DTC and its participants are on file with the SEC.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Purchases of securities under the DTC system must be made by or through direct participants, which will receive a credit for the securities on DTC&#8217;s records. The ownership interest of the actual purchaser of a security, which we sometimes refer to as a beneficial owner, is in turn recorded on the direct and indirect participants&#8217; records. Beneficial owners of securities will not receive written confirmation from DTC of their purchases. However, beneficial owners are expected to receive written confirmations providing details of their transactions, as well as periodic statements of their holdings, from the direct or indirect participants through which they purchased securities. Transfers of ownership interests in global securities are to be accomplished by entries made on the books of participants acting on behalf of beneficial owners. Beneficial owners will not receive certificates representing their ownership interests in the global securities, except under the limited circumstances described below.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">To facilitate subsequent transfers, all global securities deposited by direct participants with DTC will be registered in the name of DTC&#8217;s partnership nominee, Cede &amp; Co., or such other name as may be requested by an authorized representative of DTC. The deposit of securities with DTC and their registration in the name of Cede &amp; Co. or such other nominee will not change the beneficial ownership of the securities. DTC has no knowledge of the actual beneficial owners of the securities. DTC&#8217;s records reflect only the identity of the direct participants to whose accounts the securities are credited, which may or may not be the beneficial owners. The participants are responsible for keeping account of their holdings on behalf of their customers.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">So long as the securities are in book-entry form, you will receive payments and may transfer securities only through the facilities of the depositary and its direct and indirect participants. We will maintain an office or agency in the location specified in the prospectus supplement for the applicable securities, where notices and demands in respect of the securities and the indenture may be delivered to us and where certificated securities may be surrendered for payment, registration of transfer or exchange.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">21</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style="text-indent:20pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Conveyance of notices and other communications by DTC to direct participants, by direct participants to indirect participants and by direct participants and indirect participants to beneficial owners will be governed by arrangements among them, subject to any legal requirements in effect from time to time.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Redemption notices will be sent to DTC. If less than all of the securities of a particular series are being redeemed, DTC&#8217;s practice is to determine by lot the amount of the interest of each direct participant in the securities of such series to be redeemed.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Neither DTC nor Cede &amp; Co. (or such other DTC nominee) will consent or vote with respect to the securities. Under its usual procedures, DTC will mail an omnibus proxy to us as soon as possible after the record date. The omnibus proxy assigns the consenting or voting rights of Cede &amp; Co. to those direct participants to whose accounts the securities of such series are credited on the record date, identified in a listing attached to the omnibus proxy.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">So long as securities are in book-entry form, we will make payments on those securities to the depositary or its nominee, as the registered owner of such securities, by wire transfer of immediately available funds. If securities are issued in definitive certificated form under the limited circumstances described below and unless if otherwise provided in the description of the applicable securities herein or in the applicable prospectus supplement, we will have the option of making payments by check mailed to the addresses of the persons entitled to payment or by wire transfer to bank accounts in the United States designated in writing to the applicable trustee or other designated party at least 15&#160;days before the applicable payment date by the persons entitled to payment, unless a shorter period is satisfactory to the applicable trustee or other designated party.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Redemption proceeds, distributions and dividend payments on the securities will be made to Cede&#160;&amp; Co., or such other nominee as may be requested by an authorized representative of DTC. DTC&#8217;s practice is to credit direct participants&#8217; accounts upon DTC&#8217;s receipt of funds and corresponding detail information from us on the payment date in accordance with their respective holdings shown on DTC records. Payments by participants to beneficial owners will be governed by standing instructions and customary practices, as is the case with securities held for the account of customers in bearer form or registered in &#8220;street name.&#8221; Those payments will be the responsibility of participants and not of DTC or us, subject to any statutory or regulatory requirements in effect from time to time. Payment of redemption proceeds, distributions and dividend payments to Cede &amp; Co., or such other nominee as may be requested by an authorized representative of DTC, is our responsibility, disbursement of payments to direct participants is the responsibility of DTC, and disbursement of payments to the beneficial owners is the responsibility of direct and indirect participants.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Except under the limited circumstances described below, purchasers of securities will not be entitled to have securities registered in their names and will not receive physical delivery of securities. Accordingly, each beneficial owner must rely on the procedures of DTC and its participants to exercise any rights under the securities and the indenture.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The laws of some jurisdictions may require that some purchasers of securities take physical delivery of securities in definitive form. Those laws may impair the ability to transfer or pledge beneficial interests in securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">DTC may discontinue providing its services as securities depositary with respect to the securities at any time by giving reasonable notice to us. Under such circumstances, in the event that a successor depositary is not obtained, securities certificates are required to be printed and delivered.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">As noted above, beneficial owners of a particular series of securities generally will not receive certificates representing their ownership interests in those securities. However, if:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style=" float:left; line-height:12pt; margin-top:2pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:2pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
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          <font style="letter-spacing:-0.025pt;">DTC notifies us that it is unwilling or unable to continue as a depositary for the global security or securities representing such series of securities or if DTC ceases to be a clearing agency registered under the Exchange Act at a time when it is required to be registered and a successor depositary is not appointed within 90&#160;days of the notification to us or of our becoming aware of DTC&#8217;s ceasing to be so registered, as the case may be;</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">22</font>
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        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
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      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:6pt;margin-left:69.66pt;width:456pt;">
        <div style=" float:left; line-height:12pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">we determine, in our sole discretion, not to have such securities represented by one or more global securities; or</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style=" float:left; line-height:12pt; margin-top:1.9pt; margin-bottom:0pt; text-align:left; width:20pt;white-space:nowrap;">
          <font style="letter-spacing:-0.025pt;">&#8226;</font>
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        <div style=" margin-top:1.9pt; margin-bottom:0pt; line-height:12pt; text-align:left; margin-left:20pt;">
          <!--blacklining:none;-->
          <font style="letter-spacing:-0.025pt;">an Event of Default has occurred and is continuing with respect to such series of securities,</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="clear:both; padding:0pt; margin:0pt;font-size:0pt;line-height:0pt;">&#8203;</div>
        <div style="margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">we will prepare and deliver certificates for such securities in exchange for beneficial interests in the global securities. Any beneficial interest in a global security that is exchangeable under the circumstances described in the preceding sentence will be exchangeable for securities in definitive certificated form registered in the names that the depositary directs. It is expected that these directions will be based upon directions received by the depositary from its participants with respect to ownership of beneficial interests in the global securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="margin-left:20pt; margin-top:4pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Euroclear and Clearstream<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">If so provided in the applicable prospectus supplement, you may hold interests in a global security through Clearstream Banking S.A., which we refer to as &#8220;Clearstream,&#8221; or Euroclear Bank S.A./N.V., as operator of the Euroclear System, which we refer to as &#8220;Euroclear,&#8221; either directly if you are a participant in Clearstream or Euroclear or indirectly through organizations which are participants in Clearstream or Euroclear. Clearstream and Euroclear will hold interests on behalf of their respective participants through customers&#8217; securities accounts in the names of Clearstream and Euroclear, respectively, on the books of their respective U.S. depositaries, which in turn will hold such interests in customers&#8217; securities accounts in such depositaries&#8217; names on DTC&#8217;s books.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Clearstream and Euroclear are securities clearance systems in Europe. Clearstream and Euroclear hold securities for their respective participating organizations and facilitate the clearance and settlement of securities transactions between those participants through electronic book-entry changes in their accounts, thereby eliminating the need for physical movement of certificates.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Payments, deliveries, transfers, exchanges, notices and other matters relating to beneficial interests in global securities owned through Euroclear or Clearstream must comply with the rules and procedures of those systems. Transactions between participants in Euroclear or Clearstream, on one hand, and other participants in DTC, on the other hand, are also subject to DTC&#8217;s rules and procedures. </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Investors will be able to make and receive through Euroclear and Clearstream payments, deliveries, transfers and other transactions involving any beneficial interests in global securities held through those systems only on days when those systems are open for business. Those systems may not be open for business on days when banks, brokers and other institutions are open for business in the United States.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Cross-market transfers between participants in DTC, on the one hand, and participants in Euroclear or Clearstream, on the other hand, will be effected through DTC in accordance with the DTC&#8217;s rules on behalf of Euroclear or Clearstream, as the case may be, by their respective U.S. depositaries; however, such cross-market transactions will require delivery of instructions to Euroclear or Clearstream, as the case may be, by the counterparty in such system in accordance with the rules and procedures and within the established deadlines (European time) of such system. Euroclear or Clearstream, as the case may be, will, if the transaction meets its settlement requirements, deliver instructions to its U.S. depositary to take action to effect final settlement on its behalf by delivering or receiving interests in the global securities through DTC, and making or receiving payment in accordance with normal procedures for same-day fund settlement. Participants in Euroclear or Clearstream may not deliver instructions directly to their respective U.S. depositaries.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Due to time zone differences, the securities accounts of a participant in Euroclear or Clearstream purchasing an interest in a global security from a direct participant in DTC will be credited, and any such crediting will be reported to the relevant participant in Euroclear or Clearstream, during the securities settlement processing day (which must be a business day for Euroclear or Clearstream) immediately following the settlement date of DTC. Cash received in Euroclear or Clearstream as a result of sales of interests in a global security by or through a participant in Euroclear or Clearstream to a direct participant in DTC will be received with value on the settlement date of DTC but will be available in the relevant Euroclear or Clearstream cash account only as of the business day for Euroclear or Clearstream following DTC&#8217;s settlement date.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">23</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:458pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-left:20pt; width:436pt; line-height:12pt;font-style:italic;font-weight:bold;">Other<font style="font-style:normal;font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font></div>
        <div style="text-indent:20pt; margin-top:2pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The information in this section of this prospectus concerning DTC, Clearstream, Euroclear and their respective book-entry systems has been obtained from sources that we believe to be reliable, but we do not take responsibility for this information. This information has been provided solely as a matter of convenience. The rules and procedures of DTC, Clearstream and Euroclear are solely within the control of those organizations and could change at any time. Neither we nor the trustee nor any agent of ours or of the trustee has any control over those entities and none of us takes any responsibility for their activities. You are urged to contact DTC, Clearstream and Euroclear or their respective participants directly to discuss those matters. In addition, although we expect that DTC, Clearstream and Euroclear will perform the foregoing procedures, none of them is under any obligation to perform or continue to perform such procedures and such procedures may be discontinued at any time. Neither we nor any agent of ours will have any responsibility for the performance or nonperformance by DTC, Clearstream and Euroclear or their respective participants of these or any other rules or procedures governing their respective operations.</font>
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      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">24</font>
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          <font style="letter-spacing:-0.025pt;">We may sell the securities from time to time pursuant to underwritten public offerings, &#8220;at the market&#8221; offerings, negotiated transactions, block trades or a combination of these methods or through underwriters or dealers, through agents and/or directly to one or more purchasers. The securities may be distributed from time to time in one or more transactions:</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Each time that we sell securities covered by this prospectus, we will provide a prospectus supplement or supplements that will describe the method of distribution and set forth the terms and conditions of the offering of such securities, including the offering price of the securities and the proceeds to us, if applicable.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Offers to purchase the securities being offered by this prospectus may be solicited directly. Agents may also be designated to solicit offers to purchase the securities from time to time. Any agent involved in the offer or sale of our securities will be identified in a prospectus supplement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">If a dealer is utilized in the sale of the securities being offered by this prospectus, the securities will be sold to the dealer, as principal. The dealer may then resell the securities to the public at varying prices to be determined by the dealer at the time of resale.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">If an underwriter is utilized in the sale of the securities being offered by this prospectus, an underwriting agreement will be executed with the underwriter at the time of sale and the name of any underwriter will be provided in the prospectus supplement that the underwriter will use to make resales of the securities to the public. In connection with the sale of the securities, we or the purchasers of securities for whom the underwriter may act as agent, may compensate the underwriter in the form of underwriting discounts or commissions. The underwriter may sell the securities to or through dealers, and those dealers may receive compensation in the form of discounts, concessions or commissions from the underwriters and/or commissions from the purchasers for which they may act as agent. Unless otherwise indicated in a prospectus supplement, an agent will be acting on a best efforts basis and a dealer will purchase securities as a principal, and may then resell the securities at varying prices to be determined by the dealer.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Any compensation paid to underwriters, dealers or agents in connection with the offering of the securities, and any discounts, concessions or commissions allowed by underwriters to participating dealers will be provided in the applicable prospectus supplement. Underwriters, dealers and agents participating in the distribution of the securities may be deemed to be underwriters within the meaning of the Securities Act of 1933, as amended, and any discounts and commissions received by them and any profit realized by them on resale of the securities may be deemed to be underwriting discounts and commissions. We may enter into agreements to indemnify underwriters, dealers and agents against civil liabilities, including liabilities under the Securities Act of 1933, as amended, or to contribute to payments they may be required to make in respect thereof and to reimburse those persons for certain expenses.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:11.5pt;">
          <font style="letter-spacing:-0.025pt;">Any common stock will be listed on the Nasdaq Global Market, but any other securities may or may not be listed on a national securities exchange. To facilitate the offering of securities, certain persons participating in the offering may engage in transactions that stabilize, maintain or otherwise affect the price of the securities. This may include over-allotments or short sales of the securities, which involve the sale by persons participating in the offering of more securities than were sold to them. In these circumstances, these persons would cover such over-allotments or short positions by making purchases in the open market or by exercising their over-allotment option, if any. In addition, these persons may stabilize or maintain the price of the securities by bidding for or purchasing securities in the open market or by imposing penalty bids, whereby selling concessions allowed to dealers participating in the offering may be reclaimed if securities sold by them are repurchased in connection with </font>
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      <div style="margin-top:2.00000000000002pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">25</font>
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      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:352pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">stabilization transactions. The effect of these transactions may be to stabilize or maintain the market price of the securities at a level above that which might otherwise prevail in the open market. These transactions may be discontinued at any time.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">We may engage in at the market offerings into an existing trading market in accordance with Rule&#160;415(a)(4) under the Securities Act of 1933, as amended. In addition, we may enter into derivative transactions with third parties, or sell securities not covered by this prospectus to third parties in privately negotiated transactions. If the applicable prospectus supplement so indicates, in connection with those derivatives, the third parties may sell securities covered by this prospectus and the applicable prospectus supplement, including in short sale transactions. If so, the third party may use securities pledged by us or borrowed from us or others to settle those sales or to close out any related open borrowings of stock, and may use securities received from us in settlement of those derivatives to close out any related open borrowings of stock. The third party in such sale transactions will be an underwriter and, if not identified in this prospectus, will be named in the applicable prospectus supplement (or a post-effective amendment). In addition, we may otherwise loan or pledge securities to a financial institution or other third party that in turn may sell the securities short using this prospectus and an applicable prospectus supplement. Such financial institution or other third party may transfer its economic short position to investors in our securities or in connection with a concurrent offering of other securities.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The specific terms of any lock-up provisions in respect of any given offering will be described in the applicable prospectus supplement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
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        <div style="text-indent:20pt; margin-top:8pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">The underwriters, dealers and agents may engage in transactions with us, or perform services for us, in the ordinary course of business for which they receive compensation. </font>
        </div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">26</font>
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    <div style="page-break-after:always; width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Arial, Helvetica, sans-serif;font-size:10pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC2">TABLE OF CONTENTS</a><a name="bLEMA">&#8203;</a><a name="bEXP">&#8203;</a>
      </div>
      <div style="margin-top:15.85pt;height:24pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:17pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
      </div>
      <div style="margin-top:6pt;margin-bottom:436pt;margin-left:69.66pt;width:456pt;">
        <div style="text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">LEGAL MATTERS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Latham &amp; Watkins LLP will pass upon certain legal matters relating to the issuance and sale of the securities offered hereby on behalf of Coherus BioSciences, Inc. Additional legal matters may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement.</font><font style="font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="margin-top:12pt; text-align:center; width:456pt; line-height:12pt;font-weight:bold;">
          <font style="text-transform:uppercase;letter-spacing:-0.125pt;">EXPERTS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.2pt;"> </font>
        </div>
        <div style="text-indent:20pt; margin-top:18pt; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">Ernst &amp; Young LLP, independent registered public accounting firm, has audited our consolidated financial statements included in our <a style="-sec-extract:exhibit" href="http://www.sec.gov/ix?doc=/Archives/edgar/data/1512762/000155837022001764/chrs-20211231x10k.htm">Annual Report on Form 10-K for the year ended December&#160;31, 2021</a>, and the effectiveness of our internal control over financial reporting as of December&#160;31, 2021, as set forth in their reports, which are incorporated by reference in this prospectus and elsewhere in the registration statement. Our financial statements are incorporated by reference in reliance on Ernst &amp; Young LLP&#8217;s reports, given on their authority as experts in accounting and auditing.</font>
        </div>
      </div>
      <div style="margin-top:0pt;height:12pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">&#160;</font>
          <br >
        </div>
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      <div style="margin-top:2pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="margin-top:5pt; text-align:center; width:456pt; line-height:12pt;">
          <font style="letter-spacing:-0.025pt;">27</font>
          <br >
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    <div style=" width:595.3pt;margin-left:auto;margin-right:auto;font-style:normal;font-weight:normal;font-variant:normal;text-transform:none;color:#000000;font-family:Helvetica, Arial, sans-serif;font-size:9pt;">
      <div style="padding:0pt;margin:0pt;font-family:calibri, arial, sans-serif;font-weight:normal;font-style:normal;font-size:8pt;line-height:8pt;">
        <a style="text-decoration:none;color:#003366;" href="#TOC">TABLE OF CONTENTS</a>
      </div>
      <div style="margin-top:27.85pt;min-height:706pt;margin-bottom:21.86pt;margin-left:69.66pt;width:456pt;">
        <div style="width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 3pt; line-height: 0pt; border-bottom: 3pt solid #000000; ">&#8203;</div>
        </div>
        <div style="margin-top:98pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-family:Arial, Helvetica, sans-serif;font-size:14pt;">
          <font style="letter-spacing:-0.032pt;">Up to $</font><font style="letter-spacing:-0.175pt;">78,407,207</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.28pt;"> </font>
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        <div style="position:relative;margin-top:38pt; text-align:center; width:456pt;">
          <img src="lg_coherusbio-4c.jpg" alt="[MISSING IMAGE: lg_coherusbio-4c.jpg]" height="68" width="126" >
        </div>
        <div style="margin-top:53pt; text-align:center; width:456pt; line-height:16pt;font-weight:bold;font-family:Arial, Helvetica, sans-serif;font-size:14pt;">
          <font style="letter-spacing:-0.032pt;">Common Stock</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.28pt;"> </font>
        </div>
        <div style="margin-top:75.167pt; width:456pt;">
          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 1pt; line-height: 0pt; border-bottom: 1pt solid #5ACE5A; ">&#8203;</div>
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        <div style="margin-top:14pt; text-align:center; width:456pt; line-height:14pt;font-weight:bold;font-family:Arial, Helvetica, sans-serif;font-size:12pt;">
          <font style="letter-spacing:-0.15pt;">PROSPECTUS</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.24pt;"> </font>
        </div>
        <div style="margin-top:11.833pt; width:456pt;">
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        <div style="margin-top:26pt; text-align:center; width:456pt; line-height:18pt;font-weight:bold;font-family:Arial, Helvetica, sans-serif;font-size:16pt;">
          <font style="letter-spacing:-0.2pt;">TD </font><font style="letter-spacing:-0.036pt;">Cowen</font><font style="font-weight:normal;font-family:Times New Roman, Times, serif ;letter-spacing:0.32pt;"> </font>
        </div>
        <div style="margin-top:132pt; text-align:center; width:456pt; line-height:14pt;font-family:Arial, Helvetica, sans-serif;font-size:12pt;">
          <font style="letter-spacing:-0.03pt;">September 11, 2023</font>
        </div>
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          <div style="margin-left: 0pt; width: 456pt; margin-top: 0pt; font-size: 3pt; line-height: 0pt; border-bottom: 3pt solid #000000; ">&#8203;</div>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
