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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating activities |  |  |
Net loss | $ (237,892) | $ (291,754) | $ (287,100)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 3,791 | 3,699 | 3,454
Stock-based compensation expense | 43,110 | 50,737 | 51,364
Write-off of prepaid manufacturing services related to the termination of CHS-2020 |  |  | 3,210
Inventory write-downs, net | 52,595 | 26,000 | 5,133
Non-cash amortization of premium (accretion of discount) on marketable securities, net | (3,052) | (730) | 1,095
Non-cash interest expense from amortization of debt discount and issuance costs | 2,407 | 6,431 | 4,257
Non-cash operating lease expense | 2,476 | 2,503 | 2,207
Upfront and option payments to Junshi Biosciences |  | 35,000 | 136,000
Loss on debt extinguishment |  | 6,222 |
Other non-cash adjustments, net | (1,493) | 25 | 588
Changes in operating assets and liabilities: |  |  |
Trade receivables, net | (150,683) | 13,052 | 34,062
Inventory | (46,734) | (47,348) | (6,253)
Prepaid manufacturing | 2,027 | (4,214) | 3,828
Other prepaid, current and non-current assets | 16,155 | (13,424) | (5,351)
Accounts payable | 23,760 | (4,548) | 874
Accrued rebates, fees and reserves | 113,105 | (24,566) | (2,502)
Accrued compensation | (5,373) | 596 | (230)
Accrued and other current and non-current liabilities | 10,917 | 1,195 | 17,932
Net cash used in operating activities | (174,884) | (241,124) | (37,432)
Investing activities |  |  |
Purchases of property and equipment | (286) | (2,039) | (1,289)
Proceeds from disposal of property and equipment | 845 |  |
Purchases of investments in marketable securities | (19,507) | (127,382) | (182,485)
Proceeds from maturities of investments in marketable securities | 144,360 |  | 99,692
Proceeds from sale of investments in marketable securities | 13,282 |  | 81,672
Cash and cash equivalents acquired from Surface Acquisition | 6,997 |  |
Upfront and option payments to Junshi Biosciences |  | (35,000) | (136,000)
Milestone based license fee payments | (1,051) | (2,429) |
Net cash provided by (used in) investing activities | 144,640 | (166,850) | (138,410)
Financing activities |  |  |
Proceeds from 2027 Term Loans, net of debt discount & issuance costs |  | 240,679 |
Proceeds from issuance of common stock upon exercise of stock options | 694 | 691 | 10,399
Proceeds from purchase under the employee stock purchase plan | 1,809 | 2,320 | 3,002
Taxes paid related to net share settlement | (3,587) | (3,744) | (1,753)
Repayment of 2022 Convertible Notes and premiums |  | (109,000) |
Repayment of 2025 Term Loan, premiums and exit fees |  | (81,750) |
Other financing activities | (1,034) | (1,228) | (672)
Net cash provided by financing activities | 69,600 | 54,326 | 51,879
Net increase (decrease) in cash, cash equivalents and restricted cash | 39,356 | (353,648) | (123,963)
Cash, cash equivalents and restricted cash at beginning of period | 63,987 | 417,635 | 541,598
Cash, cash equivalents and restricted cash at end of period | 103,343 | 63,987 | 417,635
Supplemental disclosure of cash flow information |  |  |
Cash paid for interest | 37,857 | 34,878 | 18,684
Income taxes paid (refunded), net | (118) | 40 | 1,221
At The Market Offering. |  |  |
Financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs | 18,093 | $ 6,358 |
Public Offering |  |  |
Financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs | $ 53,625 |  |
Junshi Biosciences |  |  |
Financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs |  |  | $ 40,903

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