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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Pay vs Performance Disclosure |  |  |
Pay vs Performance Disclosure, Table | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Year | ​ | Summary Compensation Table Total for PEO (1) | ​ | Compensation Actually Paid to PEO (2) | ​ | Average Summary Compensation Table Total for Non-PEO NEOs (3) | ​ | Average Compensation Actually Paid to Non-PEO NEOs (3) | ​ | Value of Initial Fixed $100 Investment based on Total Shareholder Return (TSR) (4) | ​ | Net Income (Loss)
(a) | ​ | (b)($) | ​ | (c)($) | ​ | (d)($) | ​ | (e)($) | ​ | (f)($) | ​ | (g)($ in 000's)
2024 | ​ | 4,802,309 | ​ | 2,364,913 | ​ | 1,345,143 | ​ | 860,228 | ​ | 9 | ​ | 28,507
2023 | ​ | 5,897,924 | ​ | 1,734,065 | ​ | 1,863,540 | ​ | 744,699 | ​ | 21 | ​ | (237,892)
2022 | ​ | 6,866,396 | ​ | 212,826 | ​ | 2,122,124 | ​ | 470,265 | ​ | 50 | ​ | (291,754)
​
(1) | Represents total compensation paid to the principal executive officer, or PEO, Mr. Dennis Lanfear, as reflected in the Summary Compensation Table.
​
(2) | The following table sets forth the adjustments made during each year presented to arrive at CAP to our PEO during each year:
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | 2024 | ​ | 2023 | ​ | 2022
​ | ​ | ($) | ​ | ($) | ​ | ($)
Summary Compensation Table (SCT) Total Compensation | ​ | 4,802,309 | ​ | 5,897,924 | ​ | 6,866,396
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT | ​ | (2,873,088) | ​ | (4,075,681) | ​ | (5,071,908)
Fair value as of year-end of equity awards granted during the year that remain unvested | ​ | 1,112,854 | ​ | 1,161,479 | ​ | 1,795,132
Change in fair value of prior years' equity awards that remain unvested as of year-end | ​ | (627,283) | ​ | (1,100,382) | ​ | (2,186,702)
Fair value on vesting date for awards granted and vested in the same year | ​ | 317,940 | ​ | 248,745 | ​ | 433,008
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year | ​ | (367,819) | ​ | (398,020) | ​ | (1,623,100)
Compensation Actually Paid (CAP) | ​ | 2,364,913 | ​ | 1,734,065 | ​ | 212,826
​ ​
(3) | The following table sets forth the adjustments made during each year presented to arrive at CAP to our non-PEO NEOs during each year:
​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | 2024 | ​ | 2023 | ​ | 2022
​ | ​ | ($) | ​ | ($) | ​ | ($)
Average SCT Total for Non-PEO NEOs | ​ | 1,345,143 | ​ | 1,863,540 | ​ | 2,122,124
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT | ​ | (526,406) | ​ | (963,378) | ​ | (1,372,424)
Fair value as of year-end of equity awards granted during the year that remain unvested | ​ | 207,285 | ​ | 260,238 | ​ | 537,826
Change in fair value of prior years' equity awards that remain unvested as of year-end | ​ | (134,603) | ​ | (229,356) | ​ | (550,147)
Fair value on vesting date for awards granted and vested in the same year | ​ | 49,899 | ​ | 121,694 | ​ | 86,062
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year | ​ | (81,090) | ​ | (122,691) | ​ | (353,176)
Deduct fair value as of end of prior fiscal year of awards granted in any prior year that fail to meet vesting conditions during the fiscal year | ​ | — | ​ | (185,348) | ​ | —
Average CAP to Non-PEO NEOs | ​ | 860,228 | ​ | 744,699 | ​ | 470,265
​ The non-PEO NEOs included in average compensation shown in columns (d) and (e) above are as follows:
​ ​ ​ | ​ | ​ |  |
2024 | ​ | ​ | 2023 |  | 2022 |
Paul Reider | ​ | ​ | McDavid Stilwell |  | McDavid Stilwell |
Bryan McMichael | ​ | ​ | Vladimir Vexler, Ph.D. |  | Vladimir Vexler, Ph.D. |
​ | ​ | ​ | Paul Reider |  |  |
​ | ​ | ​ | Bryan McMichael |  |  |
​ ​
(4) | Total Shareholder Return, or TSR, represents the cumulative growth of a hypothetical $100 investment in the Company made as of December 31, 2021, reflected as of the end of each respective year.
Named Executive Officers, Footnote |
(1) | Represents total compensation paid to the principal executive officer, or PEO, Mr. Dennis Lanfear, as reflected in the Summary Compensation Table.
The non-PEO NEOs included in average compensation shown in columns (d) and (e) above are as follows:
​ ​ ​ | ​ | ​ |  |
2024 | ​ | ​ | 2023 |  | 2022 |
Paul Reider | ​ | ​ | McDavid Stilwell |  | McDavid Stilwell |
Bryan McMichael | ​ | ​ | Vladimir Vexler, Ph.D. |  | Vladimir Vexler, Ph.D. |
​ | ​ | ​ | Paul Reider |  |  |
​ | ​ | ​ | Bryan McMichael |  |  |
PEO Total Compensation Amount | $ 4,802,309 | $ 5,897,924 | $ 6,866,396
PEO Actually Paid Compensation Amount | $ 2,364,913 | 1,734,065 | 212,826
Adjustment To PEO Compensation, Footnote | ​
(2) | The following table sets forth the adjustments made during each year presented to arrive at CAP to our PEO during each year:
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | 2024 | ​ | 2023 | ​ | 2022
​ | ​ | ($) | ​ | ($) | ​ | ($)
Summary Compensation Table (SCT) Total Compensation | ​ | 4,802,309 | ​ | 5,897,924 | ​ | 6,866,396
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT | ​ | (2,873,088) | ​ | (4,075,681) | ​ | (5,071,908)
Fair value as of year-end of equity awards granted during the year that remain unvested | ​ | 1,112,854 | ​ | 1,161,479 | ​ | 1,795,132
Change in fair value of prior years' equity awards that remain unvested as of year-end | ​ | (627,283) | ​ | (1,100,382) | ​ | (2,186,702)
Fair value on vesting date for awards granted and vested in the same year | ​ | 317,940 | ​ | 248,745 | ​ | 433,008
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year | ​ | (367,819) | ​ | (398,020) | ​ | (1,623,100)
Compensation Actually Paid (CAP) | ​ | 2,364,913 | ​ | 1,734,065 | ​ | 212,826
Non-PEO NEO Average Total Compensation Amount | $ 1,345,143 | 1,863,540 | 2,122,124
Non-PEO NEO Average Compensation Actually Paid Amount | $ 860,228 | 744,699 | 470,265
Adjustment to Non-PEO NEO Compensation Footnote |
(3) | The following table sets forth the adjustments made during each year presented to arrive at CAP to our non-PEO NEOs during each year:
​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | 2024 | ​ | 2023 | ​ | 2022
​ | ​ | ($) | ​ | ($) | ​ | ($)
Average SCT Total for Non-PEO NEOs | ​ | 1,345,143 | ​ | 1,863,540 | ​ | 2,122,124
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT | ​ | (526,406) | ​ | (963,378) | ​ | (1,372,424)
Fair value as of year-end of equity awards granted during the year that remain unvested | ​ | 207,285 | ​ | 260,238 | ​ | 537,826
Change in fair value of prior years' equity awards that remain unvested as of year-end | ​ | (134,603) | ​ | (229,356) | ​ | (550,147)
Fair value on vesting date for awards granted and vested in the same year | ​ | 49,899 | ​ | 121,694 | ​ | 86,062
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year | ​ | (81,090) | ​ | (122,691) | ​ | (353,176)
Deduct fair value as of end of prior fiscal year of awards granted in any prior year that fail to meet vesting conditions during the fiscal year | ​ | — | ​ | (185,348) | ​ | —
Average CAP to Non-PEO NEOs | ​ | 860,228 | ​ | 744,699 | ​ | 470,265
Compensation Actually Paid vs. Total Shareholder Return | ​ ​ |  |
Compensation Actually Paid vs. Net Income | ​ |  |
Compensation Actually Paid vs. Company Selected Measure | ​ |  |
Total Shareholder Return Vs Peer Group | ​ ​ |  |
Total Shareholder Return Amount | $ 9 | 21 | 50
Net Income (Loss) | $ 28,507,000 | (237,892,000) | (291,754,000)
PEO Name | Mr. Dennis Lanfear |  |
PEO | Deduct for amounts reported under the "Stock Awards" and Option Awards" in the SCT |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ (2,873,088) | (4,075,681) | (5,071,908)
PEO | Fair value as of year-end of equity awards granted during the year that remain unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 1,112,854 | 1,161,479 | 1,795,132
PEO | Change in fair value of prior years' equity awards that remain unvested as of year-end |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (627,283) | (1,100,382) | (2,186,702)
PEO | Fair value on vesting date for awards granted and vested in the same year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 317,940 | 248,745 | 433,008
PEO | Change in fair value from prior year-end to vesting date of prior years' awards that vested during year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (367,819) | (398,020) | (1,623,100)
Non-PEO NEO | Deduct for amounts reported under the "Stock Awards" and Option Awards" in the SCT |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (526,406) | (963,378) | (1,372,424)
Non-PEO NEO | Fair value as of year-end of equity awards granted during the year that remain unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 207,285 | 260,238 | 537,826
Non-PEO NEO | Change in fair value of prior years' equity awards that remain unvested as of year-end |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (134,603) | (229,356) | (550,147)
Non-PEO NEO | Fair value on vesting date for awards granted and vested in the same year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 49,899 | 121,694 | 86,062
Non-PEO NEO | Change in fair value from prior year-end to vesting date of prior years' awards that vested during year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ (81,090) | (122,691) | $ (353,176)
Non-PEO NEO | Deduct fair value as of end of prior fiscal year of awards granted in any prior year that fail to meet vesting conditions during the fiscal year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount |  | $ (185,348) |

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