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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022

Pay vs Performance Disclosure

Pay vs Performance Disclosure, Table

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Year

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Summary Compensation Table Total for PEO (1)

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Compensation Actually Paid to PEO (2)

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Average Summary Compensation Table Total for Non-PEO NEOs (3)

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Average Compensation Actually Paid to Non-PEO NEOs (3)

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Value of Initial Fixed $100 Investment based on Total Shareholder Return (TSR) (4)

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Net Income (Loss)

(a)

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(b)($)

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(c)($)

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(d)($)

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(e)($)

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(f)($)

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(g)($ in 000's)

2024

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4,802,309

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2,364,913

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1,345,143

​

860,228

​

9

​

28,507

2023

​

5,897,924

​

1,734,065

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1,863,540

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744,699

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21

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(237,892)

2022

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6,866,396

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212,826

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2,122,124

​

470,265

​

50

​

(291,754)

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(1) Represents total compensation paid to the principal executive officer, or PEO, Mr. Dennis Lanfear, as reflected in the Summary Compensation Table.

​

(2) The following table sets forth the adjustments made during each year presented to arrive at CAP to our PEO during each year:

​	​	​	​	​	​	​
​	​	2024	​	2023	​	2022
​	​	($)	​	($)	​	($)
Summary Compensation Table (SCT) Total Compensation	​	4,802,309	​	5,897,924	​	6,866,396
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT	​	(2,873,088)	​	(4,075,681)	​	(5,071,908)
Fair value as of year-end of equity awards granted during the year that remain unvested	​	1,112,854	​	1,161,479	​	1,795,132
Change in fair value of prior years' equity awards that remain unvested as of year-end	​	(627,283)	​	(1,100,382)	​	(2,186,702)
Fair value on vesting date for awards granted and vested in the same year	​	317,940	​	248,745	​	433,008
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year	​	(367,819)	​	(398,020)	​	(1,623,100)
Compensation Actually Paid (CAP)	​	2,364,913	​	1,734,065	​	212,826

​

​

(3) The following table sets forth the adjustments made during each year presented to arrive at CAP to our non-PEO NEOs during each year:

​

​	​	​	​	​	​	​
​	​	2024	​	2023	​	2022
​	​	($)	​	($)	​	($)
Average SCT Total for Non-PEO NEOs	​	1,345,143	​	1,863,540	​	2,122,124
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT	​	(526,406)	​	(963,378)	​	(1,372,424)
Fair value as of year-end of equity awards granted during the year that remain unvested	​	207,285	​	260,238	​	537,826
Change in fair value of prior years' equity awards that remain unvested as of year-end	​	(134,603)	​	(229,356)	​	(550,147)
Fair value on vesting date for awards granted and vested in the same year	​	49,899	​	121,694	​	86,062
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year	​	(81,090)	​	(122,691)	​	(353,176)
Deduct fair value as of end of prior fiscal year of awards granted in any prior year that fail to meet vesting conditions during the fiscal year	​	—	​	(185,348)	​	—
Average CAP to Non-PEO NEOs	​	860,228	​	744,699	​	470,265

​

The non-PEO NEOs included in average compensation shown in columns (d) and (e) above are as follows:

​ ​ ​	​	​
2024			​	​	2023			2022
Paul Reider			​	​	McDavid Stilwell			McDavid Stilwell
Bryan McMichael			​	​	Vladimir Vexler, Ph.D.			Vladimir Vexler, Ph.D.
​			​	​	Paul Reider
​			​	​	Bryan McMichael

​

​

(4) Total Shareholder Return, or TSR, represents the cumulative growth of a hypothetical $100 investment in the Company made as of December 31, 2021, reflected as of the end of each respective year.

Named Executive Officers, Footnote

(1) Represents total compensation paid to the principal executive officer, or PEO, Mr. Dennis Lanfear, as reflected in the Summary Compensation Table.

The non-PEO NEOs included in average compensation shown in columns (d) and (e) above are as follows:

​ ​ ​	​	​
2024			​	​	2023			2022
Paul Reider			​	​	McDavid Stilwell			McDavid Stilwell
Bryan McMichael			​	​	Vladimir Vexler, Ph.D.			Vladimir Vexler, Ph.D.
​			​	​	Paul Reider
​			​	​	Bryan McMichael

PEO Total Compensation Amount

$ 4,802,309

$ 5,897,924

$ 6,866,396

PEO Actually Paid Compensation Amount

$ 2,364,913

1,734,065

212,826

Adjustment To PEO Compensation, Footnote

​

(2) The following table sets forth the adjustments made during each year presented to arrive at CAP to our PEO during each year:

​	​	​	​	​	​	​
​	​	2024	​	2023	​	2022
​	​	($)	​	($)	​	($)
Summary Compensation Table (SCT) Total Compensation	​	4,802,309	​	5,897,924	​	6,866,396
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT	​	(2,873,088)	​	(4,075,681)	​	(5,071,908)
Fair value as of year-end of equity awards granted during the year that remain unvested	​	1,112,854	​	1,161,479	​	1,795,132
Change in fair value of prior years' equity awards that remain unvested as of year-end	​	(627,283)	​	(1,100,382)	​	(2,186,702)
Fair value on vesting date for awards granted and vested in the same year	​	317,940	​	248,745	​	433,008
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year	​	(367,819)	​	(398,020)	​	(1,623,100)
Compensation Actually Paid (CAP)	​	2,364,913	​	1,734,065	​	212,826

Non-PEO NEO Average Total Compensation Amount

$ 1,345,143

1,863,540

2,122,124

Non-PEO NEO Average Compensation Actually Paid Amount

$ 860,228

744,699

470,265

Adjustment to Non-PEO NEO Compensation Footnote

(3) The following table sets forth the adjustments made during each year presented to arrive at CAP to our non-PEO NEOs during each year:

​

​	​	​	​	​	​	​
​	​	2024	​	2023	​	2022
​	​	($)	​	($)	​	($)
Average SCT Total for Non-PEO NEOs	​	1,345,143	​	1,863,540	​	2,122,124
Deduct for amounts reported under the "Stock Awards" and "Option Awards" in the SCT	​	(526,406)	​	(963,378)	​	(1,372,424)
Fair value as of year-end of equity awards granted during the year that remain unvested	​	207,285	​	260,238	​	537,826
Change in fair value of prior years' equity awards that remain unvested as of year-end	​	(134,603)	​	(229,356)	​	(550,147)
Fair value on vesting date for awards granted and vested in the same year	​	49,899	​	121,694	​	86,062
Change in fair value from prior year-end to vesting date of prior years' awards that vested during year	​	(81,090)	​	(122,691)	​	(353,176)
Deduct fair value as of end of prior fiscal year of awards granted in any prior year that fail to meet vesting conditions during the fiscal year	​	—	​	(185,348)	​	—
Average CAP to Non-PEO NEOs	​	860,228	​	744,699	​	470,265

Compensation Actually Paid vs. Total Shareholder Return

​

​

Compensation Actually Paid vs. Net Income

​

Compensation Actually Paid vs. Company Selected Measure

​

Total Shareholder Return Vs Peer Group

​

​

Total Shareholder Return Amount

$ 9

21

50

Net Income (Loss)

$ 28,507,000

(237,892,000)

(291,754,000)

PEO Name

Mr. Dennis Lanfear

PEO | Deduct for amounts reported under the "Stock Awards" and Option Awards" in the SCT

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (2,873,088)

(4,075,681)

(5,071,908)

PEO | Fair value as of year-end of equity awards granted during the year that remain unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

1,112,854

1,161,479

1,795,132

PEO | Change in fair value of prior years' equity awards that remain unvested as of year-end

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(627,283)

(1,100,382)

(2,186,702)

PEO | Fair value on vesting date for awards granted and vested in the same year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

317,940

248,745

433,008

PEO | Change in fair value from prior year-end to vesting date of prior years' awards that vested during year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(367,819)

(398,020)

(1,623,100)

Non-PEO NEO | Deduct for amounts reported under the "Stock Awards" and Option Awards" in the SCT

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(526,406)

(963,378)

(1,372,424)

Non-PEO NEO | Fair value as of year-end of equity awards granted during the year that remain unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

207,285

260,238

537,826

Non-PEO NEO | Change in fair value of prior years' equity awards that remain unvested as of year-end

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(134,603)

(229,356)

(550,147)

Non-PEO NEO | Fair value on vesting date for awards granted and vested in the same year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

49,899

121,694

86,062

Non-PEO NEO | Change in fair value from prior year-end to vesting date of prior years' awards that vested during year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (81,090)

(122,691)

$ (353,176)

Non-PEO NEO | Deduct fair value as of end of prior fiscal year of awards granted in any prior year that fail to meet vesting conditions during the fiscal year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (185,348)

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