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Income Taxes - Components of Net Deferred Tax Assets (Liabilities) (Details) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 158,090 | $ 170,402
Research and development credits | 72,031 | 65,225
Depreciation and amortization | 28,861 | 37,211
Stock-based compensation | 26,814 | 30,370
Sales related accruals | 39,966 | 38,474
Other accruals | 42,537 | 42,480
Capitalized research and development | 50,850 | 46,062
Total gross deferred tax assets | 419,149 | 430,224
Valuation allowance | (412,833) | (423,385)
Total net deferred tax assets | 6,316 | 6,839
Deferred tax liabilities: |  |
Right-of-use asset | (1,004) | (1,538)
In-process research and development | (6,414) | (6,403)
Total deferred tax liabilities | (7,418) | (7,941)
Net deferred tax liabilities | $ (1,102) | $ (1,102)

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