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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2024
Income Taxes |
Schedule of Components of Loss from Continuing Operations Before Income Taxes | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31,
(in thousands) |  | 2024 |  | 2023
Domestic | ​ | $ | (215,394) | ​ | $ | (222,142)
Foreign | ​ |  | — | ​ |  | —
Total | ​ | $ | (215,394) | ​ | $ | (222,142)
Schedule of Income Tax Provision (Benefit) | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31,
(in thousands) |  | 2024 |  | 2023
Current: |  | ​ |  |  | ​ |
Federal | ​ | $ | — | ​ | $ | —
State | ​ |  | — | ​ |  | —
Foreign | ​ |  | — | ​ |  | —
Subtotal | ​ | $ | — | ​ | $ | —
​ | ​ |  |  | ​ |  |
Deferred: | ​ |  |  | ​ |  |
Federal | ​ | $ | — | ​ | $ | (380)
State | ​ |  | — | ​ |  | —
Foreign | ​ |  | — | ​ |  | —
Subtotal | ​ | $ | — | ​ | $ | (380)
​ | ​ |  |  | ​ |  |
Income tax provision (benefit) | ​ | $ | — | ​ | $ | (380)
Schedule of Reconciliation of the Statutory United States Federal Rate to the Company's Effective Tax Rate | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31,
​ |  | 2024 |  | 2023 |
Percent of pre-tax income: |  |  |  |  |
United States federal statutory income tax rate |  | 21.0 | % | 21.0 | %
State taxes, net of federal benefit |  | (0.4) |  | (1.3) |
Permanent items | ​ | 0.2 |  | — |
Research and development credit |  | 3.2 |  | 0.9 |
Stock-based compensation costs | ​ | (4.2) | ​ | (3.7) | ​
Other |  | (0.7) |  | 0.8 |
Change in valuation allowance | ​ | (19.1) |  | (17.5) |
Effective income tax rate |  | — | % | 0.2 | %
Schedule of Components of the Company's Net Deferred Tax Assets (Liabilities) | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31,
(in thousands) |  | 2024 |  | 2023
Deferred tax assets: | ​ | ​ | ​ | ​ | ​ | ​
Net operating loss carryforwards | ​ | $ | 158,090 | ​ | $ | 170,402
Research and development credits | ​ |  | 72,031 | ​ |  | 65,225
Depreciation and amortization | ​ |  | 28,861 | ​ |  | 37,211
Stock-based compensation | ​ |  | 26,814 | ​ |  | 30,370
Sales related accruals | ​ |  | 39,966 | ​ |  | 38,474
Other accruals | ​ |  | 42,537 | ​ |  | 42,480
Capitalized research and development | ​ | ​ | 50,850 | ​ | ​ | 46,062
Total gross deferred tax assets | ​ |  | 419,149 | ​ |  | 430,224
Valuation allowance | ​ |  | (412,833) | ​ |  | (423,385)
Total net deferred tax assets | ​ | ​ | 6,316 | ​ | ​ | 6,839
Deferred tax liabilities: | ​ | ​ | ​ | ​ | ​ | ​
Right-of-use asset | ​ |  | (1,004) | ​ |  | (1,538)
In-process research and development | ​ |  | (6,414) | ​ |  | (6,403)
Total deferred tax liabilities | ​ |  | (7,418) | ​ |  | (7,941)
Net deferred tax liabilities | ​ | $ | (1,102) | ​ | $ | (1,102)
Schedule of Reconciliation of the Company's Unrecognized Tax Benefits | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
--- | --- | --- | --- | --- | --- | ---
​ | ​ | Year Ended December 31,
(in thousands) |  | 2024 |  | 2023
Balance at beginning of year | ​ | $ | 17,417 | ​ | $ | 16,838
Additions based on tax positions related to current year | ​ |  | 1,565 | ​ |  | 865
Additions (reductions) for tax positions of prior years | ​ |  | 265 | ​ |  | (286)
Balance at end of year | ​ | $ | 19,247 | ​ | $ | 17,417

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