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Income Taxes (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Operating Loss Carryforwards [Line Items]      
Net deferred tax liabilities $ 1,102 $ 1,102  
Increase and (decrease) Valuation allowance (10,600) 85,600  
Unrecognized tax benefits 19,247 17,417 $ 16,838
Unrecognized tax benefits, accrued interest and penalties accrued 0 $ 0 $ 0
Domestic Tax Jurisdiction      
Operating Loss Carryforwards [Line Items]      
Net operating loss carryforwards $ 718,700    
Net operating loss carryforwards expiration year 2036    
State and Local Jurisdiction      
Operating Loss Carryforwards [Line Items]      
Net operating loss carryforwards $ 124,800    
Net operating loss carryforwards expiration year 2031    
Federal research and development | Domestic Tax Jurisdiction      
Operating Loss Carryforwards [Line Items]      
Tax credit carryforwards $ 66,700    
Tax credit carryforwards expiration year 2031    
Federal research and development | State and Local Jurisdiction      
Operating Loss Carryforwards [Line Items]      
Tax credit carryforwards $ 29,500