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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2025
Share-Based Payment Arrangement [Abstract] |
Summary of Stock Option Activity | The following table summarizes the stock option activity for the year ended December 31, 2025:
|  | Number of Options |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Life (Years) |  |  | Aggregate Intrinsic Value (in thousands) |
Balance- December 31, 2024 |  |  | 5,384,142 |  |  | $ | 9.61 |  |  |  | 7.8 |  |  | $ | 1,022 |
Change in authorized shares |  |  | — |  |  |  |  |  |  |  |  |  |
Granted |  |  | 2,964,646 |  |  |  | 4.38 |  |  |  |  |  |  |
Exercised |  |  | (136,871 | ) |  |  | 5.22 |  |  |  |  |  |  |
Forfeited/expired |  |  | (297,859 | ) |  |  | 9.24 |  |  |  |  |  |  |
Balance- December 31, 2025 |  |  | 7,914,058 |  |  | $ | 7.74 |  |  |  | 7.9 |  |  | $ | 46,246 |
Vested and Exercisable- December 31, 2025 |  |  | 3,717,317 |  |  | $ | 8.45 |  |  |  | 7.1 |  |  | $ | 18,914 |
Summary of Estimated Fair Value of Stock Options Granted Weighted Average Assumptions | The weighted-average grant date fair value of stock options granted during the year ended December 31, 2025 and 2024 was $3.67 and $8.81, respectively, and were estimated on the date of grant using a Black-Scholes option pricing model with the following weighted-average assumptions:
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |
Weighted-average risk-free interest rate |  |  | 4.4 | % |  |  | 4.4 | %
Expected term of stock options (in years) |  | 6.0 years |  |  | 6.0 years |
Weighted-average expected stock price volatility |  |  | 108.1 | % |  |  | 110.1 | %
Estimated dividend yield |  |  | — |  |  |  | — |
Schedule of Stock-based Compensation Expense | Stock-based compensation expense recorded as research and development and general and administrative expenses in the statements of operations and comprehensive loss is as follows (in thousands):
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |
Research and development |  | $ | 3,188 |  |  | $ | 1,939 |
General and administrative |  |  | 8,503 |  |  |  | 5,040 |
Total stock-based compensation expense |  | $ | 11,691 |  |  | $ | 6,979 |

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