<SEC-DOCUMENT>0001193125-25-221020-index.html : 20250929
<SEC-HEADER>0001193125-25-221020.hdr.sgml : 20250929
<ACCEPTANCE-DATETIME>20250926214103
ACCESSION NUMBER:		0001193125-25-221020
CONFORMED SUBMISSION TYPE:	424B3
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20250929
DATE AS OF CHANGE:		20250926

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Scilex Holding Co
		CENTRAL INDEX KEY:			0001820190
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-280882
		FILM NUMBER:		251351919

	BUSINESS ADDRESS:	
		STREET 1:		960 SAN ANTONIO ROAD
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94303
		BUSINESS PHONE:		(650) 516-4310

	MAIL ADDRESS:	
		STREET 1:		960 SAN ANTONIO ROAD
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94303

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Scilex Holding Company/DE
		DATE OF NAME CHANGE:	20221117

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Vickers Vantage Corp. I
		DATE OF NAME CHANGE:	20200804
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B3
<SEQUENCE>1
<FILENAME>d53261d424b3.htm
<DESCRIPTION>424B3
<TEXT>
Document 1 - file: d53261d424b3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g53261g0927040008841.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g53261g0927040008841.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g53261g0927040009043.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g53261g0927040009043.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g53261g0927040009177.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g53261g0927040009177.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g53261g0927040009327.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g53261g0927040009327.jpg

</DOCUMENT>
</SEC-DOCUMENT>