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Condensed Consolidated Statements of Stockholders' Equity / (Deficit) - USD ($) $ in Thousands | Total | Preferred Stock [Member] | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income | Accumulated Deficit | Treasury Stock | Treasury Stock
--- | --- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2022 |  | 29,057,000 | 4,038,000 |  |  |  | 0 |
Balance at Dec. 31, 2022 | $ 36,239 | $ 3 | $ 1 | $ 412,149 | $ 0 | $ (375,914) | $ 0 |
Shares issued under the Standby Equity Purchase Agreements (in shares) |  |  | 379,000 |  |  |  |  |
Shares issued under the Standby Equity Purchase Agreements | 34,258 |  | $ 0 | 34,258 |  |  |  |
Disbursement of funds to Sorrento Amount | (20,000) |  |  | (20,000) |  |  |  |
Repurchase of Treasury Stock, Preferred Stock, and warrants, (in shares) |  |  |  |  |  |  | (1,716,000) |
Repurchase of Treasury Stock, Preferred Stock, and warrants | (143,721) | (3) |  | (53,196) |  |  | $ (90,522) |
Issuance of penny warrants | 10,401 |  |  | 10,401 |  |  |  |
Issuance of common stock in connection with Settlement Agreement, (in shares) |  |  | 14,000 |  |  |  |  |
Issuance of common stock in connection with Settlement Agreement | 750 |  |  | 750 |  |  |  |
Conversion of Convertible Debentures into common stock, shares |  |  | 18,000 |  |  |  |  |
Conversion of Convertible Debentures into common stock | 7,735 |  |  | 7,735 |  |  |  |
Retainer shares issued (in shares) |  |  | 114,000 |  |  |  |  |
Retainer shares issued | 0 |  | $ 0 |  |  |  |  |
Issuance of common stock upon warrants exercise, shares |  |  | 1,000 |  |  |  |  |
Issuance of common stock upon warrants exercise | 521 |  |  | 521 |  |  |  |
Stock options exercised (in shares) |  |  | 10,000 |  |  |  |  |
Stock options exercised | 614 |  |  | 614 |  |  |  |
Stock-based compensation | 14,596 |  |  | 14,596 |  |  |  |
Net income (loss) | (114,331) |  |  |  |  | (114,331) |  |
Placement Agent Shares and October 2024 Placement Agent Warrants | 0 |  |  |  |  |  |  |
Conversion of Tranche B Notes into common stock | 0 |  |  |  |  |  |  |
StockBlock Warrants issued in connection with the December 2024 RDO | 0 |  |  |  |  |  |  |
Other comprehensive income | 0 |  |  |  |  |  |  |
Stock-based compensation | 14,596 |  |  |  |  |  |  |
Balance at Dec. 31, 2023 | $ (172,938) | $ 0 | $ 1 | $ 407,828 | 0 | (490,245) | $ (90,522) | $ (90,522)
Balance (in shares) at Dec. 31, 2023 |  | 29,057,000 | 4,574,000 |  |  |  | (1,716,000) |
Balance, ( In shares) at Dec. 31, 2023 |  |  |  |  |  |  |  | 1,716,000
Stock options exercised (in shares) | 46,000 |  | 1,000 | 46,000 |  |  |  |
Net income (loss) | $ (24,377) |  |  |  |  | (24,377) |  |
Shares issued under Standby Equity Purchase Agreements and under ATM Sales Agreement, Value | 156 |  |  | $ 156 |  |  |  |
Shares issued under Standby Equity Purchase Agreements and under ATM Sales Agreement, Share |  |  | 5,000 |  |  |  |  |
Shares issued under Bought Deal Offering |  |  | 168,000 |  |  |  |  |
Shares issued under Bought Deal Offering | 3,769 |  |  | 3,769 |  |  |  |
Stock-based compensation | 3,558 |  |  | 3,558 |  |  |  |
Balance at Mar. 31, 2024 | (189,786) |  | $ 1 | 415,357 |  | (514,622) |  | $ (90,522)
Balance (in shares) at Mar. 31, 2024 |  | 29,057,000 | 4,748,000 |  |  |  |  |
Balance, ( In shares) at Mar. 31, 2024 |  |  |  |  |  |  |  | 1,716,000
Balance (in shares) at Dec. 31, 2023 |  | 29,057,000 | 4,574,000 |  |  |  | (1,716,000) |
Balance at Dec. 31, 2023 | (172,938) | $ 0 | $ 1 | 407,828 | 0 | (490,245) | $ (90,522) | $ (90,522)
Balance (in shares) at Dec. 31, 2023 |  |  |  |  |  |  |  | 1,716,000
Retainer shares issued (in shares) |  |  | 286,000 |  |  |  |  |
Retainer shares issued | 0 |  | $ 0 |  |  |  |  |
Issuance of common stock upon warrants exercise, shares |  |  | 321,000 |  |  |  |  |
Issuance of common stock upon warrants exercise | 2,311 |  | $ 0 | 2,311 |  |  |  |
Stock options exercised (in shares) |  |  | 4,000 |  |  |  |  |
Stock options exercised | 227 |  |  | 227 |  |  |  |
Stock-based compensation | 15,690 |  |  | 15,690 |  |  |  |
Net income (loss) | (72,807) |  |  |  |  | (72,807) |  |
Shares issued under Standby Equity Purchase Agreements and under ATM Sales Agreement, Value | 2,671 |  |  | 2,671 |  |  |  |
Shares issued under Standby Equity Purchase Agreements and under ATM Sales Agreement, Share |  |  | 81,000 |  |  |  |  |
Shares issued under Bought Deal Offering |  |  | 168,000 |  |  |  |  |
Shares issued under Bought Deal Offering | 3,769 |  | $ 0 | 3,769 |  |  |  |
Shares issued under Registered Direct Offering, shares |  |  | 429,000 |  |  |  |  |
Shares issued under Registered Direct Offering | 5,919 |  | $ 0 | 5,919 |  |  |  |
Placement Agent Warrants issued in connection with Registered Direct Offering and Representative Warrants issued in connection with Bought Deal Offering | 956 |  |  | 956 |  |  |  |
Fee Warrant issued in connection with the Commitment Letter | 310 |  |  | 310 |  |  |  |
Repurchase of warrants | (298) |  |  | (298) |  |  |  |
Common stock issuable under Sponsor Interest Purchase Agreement | 345 |  |  | 345 |  |  |  |
Placement Agent Shares and October 2024 Placement Agent Warrants, Shares |  |  | 63,000 |  |  |  |  |
Placement Agent Shares and October 2024 Placement Agent Warrants | 3,792 |  |  | 3,792 |  |  |  |
Conversion of Tranche B Notes into common stock, Shares |  |  | 263,000 |  |  |  |  |
Conversion of Tranche B Notes into common stock | 9,256 |  | $ 0 | 9,256 |  |  |  |
Shares issued under December 2024 RDO, Shares |  |  | 753,000 |  |  |  |  |
Shares issued under December 2024 RDO, Value | 328 |  | $ 0 | 328 |  |  |  |
StockBlock Warrants issued in connection with the December 2024 RDO | 1,265 |  |  | 1,265 |  |  |  |
Stock dividend declared, not yet distributed, Shares |  | 5,000,000 |  |  |  |  |  |
Stock dividend declared, not yet distributed |  | $ 1 |  | (1) |  |  |  |
Shares issued under ESPP, shares |  |  | 10,000 |  |  |  |  |
Shares issued under ESPP | 246 |  |  | 246 |  |  |  |
Other comprehensive income | 6,317 |  |  |  | 6,317 |  |  |
Stock-based compensation | 15,689 |  |  |  |  |  |  |
Balance at Dec. 31, 2024 | (192,641) | $ 1 | $ 1 | 454,614 | 6,317 | (563,052) | $ (90,522) | $ (90,522)
Balance (in shares) at Dec. 31, 2024 |  | 34,057,000 | 6,952,000 |  |  |  | (1,716,000) |
Balance, ( In shares) at Dec. 31, 2024 |  |  |  |  |  |  |  | 1,716,000
Net income (loss) | (26,080) |  |  |  |  | (26,080) |  |
Treasury Stock transferred to Tranche B Investors for Tranche B Notes deferral | 2,182 |  |  | (5,353) |  |  |  | $ 7,535
Treasury Stock transferred to Tranche B Investors for Tranche B Note deferral, Shares |  |  |  |  |  |  |  | (143,000)
Treasury Stock paid for Gloperba Ex-U.S. License | 366 |  |  | (808) |  |  |  | $ 1,174
Treasury Stock paid for Gloperba Ex-U.S. License, Shares |  |  |  |  |  |  |  | (22,000)
Treasury Stock transferred to Oramed for the Oramed Note maturity extension | 1,375 |  |  | (3,523) |  |  |  | $ 4,898
Treasury Stock transferred to Oramed for the Oramed Note maturity extension, Shares |  |  |  |  |  |  |  | (93,000)
Stock-based compensation | 3,314 |  |  | 3,314 |  |  |  |
Balance at Mar. 31, 2025 | $ (211,484) | $ 1 | $ 1 | $ 448,244 | $ 6,317 | $ (589,132) |  | $ (76,915)
Balance (in shares) at Mar. 31, 2025 |  | 34,057,000 | 6,952,000 |  |  |  |  |
Balance, ( In shares) at Mar. 31, 2025 |  |  |  |  |  |  |  | 1,458,000

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