<SEC-DOCUMENT>0001829126-25-000014.txt : 20250422
<SEC-HEADER>0001829126-25-000014.hdr.sgml : 20250422
<ACCEPTANCE-DATETIME>20250102192512
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001829126-25-000014
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250102

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NEONC TECHNOLOGIES HOLDINGS, INC.
		CENTRAL INDEX KEY:			0001979414
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				921954864
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		23975 PARK SORRENTO
		STREET 2:		SUITE 205
		CITY:			CALABASAS
		STATE:			CA
		ZIP:			91302
		BUSINESS PHONE:		310 663 7831

	MAIL ADDRESS:	
		STREET 1:		23975 PARK SORRENTO
		STREET 2:		SUITE 205
		CITY:			CALABASAS
		STATE:			CA
		ZIP:			91302
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
<FILENAME>filename1.htm
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="vertical-align: top; width: 80%; text-align: justify"><IMG SRC="corresp_001.jpg" ALT="" STYLE="height: 58px; width: 200px"></TD>
    <TD STYLE="vertical-align: top; white-space: nowrap; width: 20%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Thomas J. Poletti</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Manatt, Phelps &amp; Phillips, LLP</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Direct Dial: (714) 371-2501</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">TPoletti@manatt.com</P> </TD> </TR>
  <TR>
    <TD STYLE="vertical-align: top; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; white-space: nowrap">&nbsp;</TD> </TR>
  <TR>
    <TD STYLE="vertical-align: top; text-align: justify">January 2, 2025</TD>
    <TD STYLE="vertical-align: top; white-space: nowrap">Client-Matter: 70244-031</TD> </TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify; margin: 0"><B>VIA EDGAR</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify; margin: 0">U.S. Securities and Exchange Commission<BR>Division
of Corporate Finance<BR>100 F Street, NE</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify; margin: 0">Washington, D.C. 20549</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: justify; margin: 0">Attention: Christine Torney; Lynn Dicker; Tyler Howes; Joshua Gorsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.5in; font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt"><B>Re:</B></FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>NeOnc Technologies Holdings, Inc.</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Amendment No. 1 to Draft Registration
Statement on Form S-1</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Submitted December 10, 2024</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>CIK No. 0001979414</B></P></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Dear Ms. Christine Torney, Ms. Lynn Dicker, Mr.
Tyler Howes and Mr. Joshua Gorsky:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">On behalf of our client, NeOnc
Technologies Holdings, Inc. (the &ldquo;Company&rdquo;), we hereby file the Company&rsquo;s Form S-1 (the &ldquo;Registration Statement&rdquo;).
The Registration Statement is filed to provide responses to comments (the &ldquo;Comments&rdquo;) of the staff (the &ldquo;Staff&rdquo;)
of the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) issued in a letter dated December 20, 2024 (the &ldquo;Staff&rsquo;s
Letter&rdquo;) relating to the Company&rsquo;s Amendment No. 1 to Draft Registration Statement on Form S-1 as confidentially submitted
with the Commission on December 10, 2024. In order to facilitate your review, we have responded, on behalf of the Company, to each of
the Comments set forth in the Staff&rsquo;s Letter, on a point by point basis. The Comments are set forth below in bold font and our response
follows each respective Comment. In our response, page number references are to the Registration Statement, and terms used but not defined
herein have the respective meanings assigned thereto in the Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><U>Amendment No. 1 to Draft Registration Statement on Form S-1</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><U>Cover Page</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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    <TD STYLE="width: 0.25in; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 0.25in; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>1.</B></FONT></TD>
    <TD STYLE="font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt"><B>We note your disclosure on the cover page, and elsewhere, that the Advisor &ldquo;will exercise any consultation rights only to the extent that it can do so consistent with the anti-manipulation provisions of the federal securities laws, including Regulation M[.]&rdquo; We also note your disclosure on page 204 that the Advisor will be &ldquo;entitled to a fee upon the successful consummation of the Direct Listing and will be granted thirty thousand shares (30,000) in unrestricted stock at the effective date of this offering at the direct listing price[,]&rdquo; and that the Advisor will be &ldquo;paid up to $100,000 for fees and expenses of legal counsel and other out-of-pocket expenses plus the costs associated with the use of a third-party electronic road show service (such as NetRoadShow).&rdquo; Please explain to us how the &ldquo;third-party electronic road show service&rdquo; will be utilized in the Direct Listing. Additionally, please explain whether your disclosure of the Advisor&rsquo;s fee upon the successful consummation of the Direct Listing, the granting of the 30,000 shares in unrestricted stock at the effective date, and the use of the &ldquo;third-party electronic road show service&rdquo; is consistent with your disclosure that the Advisor &ldquo;will exercise any consultation rights only to the extent that it can do so consistent with the anti-manipulation provisions of the federal securities laws, including Regulation M[.]&rdquo;</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify"><B>Response: </B>In response to the
Staff&rsquo;s comment, please note that references to a &ldquo;third-party electronic road show service&rdquo; have been removed from
the registration statement. Please be advised that no such service will be utilized in the Direct Listing and any references to such were
inaccurate and have been corrected. Also note that references to the Advisor being granted thirty thousand shares (30,000) in unrestricted
stock at the effective date of this offering at the direct listing price have been corrected as well. The shares will be issued immediately
prior to the effective date of the offering and will be registered in connection with the direct listing. Please also note that further
edits have been made to indicate that the Advisor will not sell any of such shares within the five day period following the effective
date of the direct listing in accordance with the provisions of Regulation M.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify">&nbsp;</P>



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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="font: normal 10pt Times New Roman, Times, Serif; text-align: left; margin-top: 0pt; margin-bottom: 0pt"><IMG SRC="corresp_001.jpg" ALT="" STYLE="height: 58px; width: 200px"></P><P STYLE="font: normal 10pt Times New Roman, Times, Serif; text-align: left; margin-top: 3pt; margin-bottom: 0pt">Attention: Christine Torney; Lynn Dicker; Tyler Howes; Joshua Gorsky<BR> Re: NeOnc Technologies Holdings, Inc. Amendment No. 1 to Draft Registration Statement on Form S-1<BR> January 2, 2025<BR> Page <!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Should you or the staff have
questions regarding the foregoing responses or additional comments please contact Thomas Poletti at 714.371.2501 or Veronica Lah at 310.312.4130.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <TD STYLE="text-align: left; vertical-align: bottom; width: 50%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: bottom; width: 50%; vertical-align: bottom">Sincerely,</TD> </TR>
  <TR>
    <TD STYLE="text-align: left; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD> </TR>
  <TR>
    <TD STYLE="text-align: left; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: bottom; border-bottom: Black 1pt solid; vertical-align: bottom">/s/ Thomas J. Poletti</TD> </TR>
  <TR>
    <TD STYLE="text-align: left; vertical-align: bottom; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: left; vertical-align: bottom; vertical-align: bottom">Thomas J. Poletti</TD> </TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <TD STYLE="vertical-align: top; width: 0.25in">cc:</TD>
    <TD STYLE="vertical-align: top; text-align: justify">NeOnc Technologies Holdings, Inc.</TD> </TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 1pt; text-align: center">Manatt, Phelps &amp; Phillips, LLP 695 Town Center
Drive, 14th Floor, Costa Mesa, California 92626</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 1pt; text-align: center">Tel: 714.371.2500 Fax: 714.371.2550</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0pt 1pt; text-align: center">Albany | Boston | Chicago | Los Angeles
| New York | Orange County | Sacramento | San Francisco | Silicon Valley | Washington, D.C.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>



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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
