<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>12
<FILENAME>e26589ex32_1.txt
<DESCRIPTION>CERTIFICATION
<TEXT>
                                                                    EXHIBIT 32.1

                         PROTALIX BIOTHERAPEUTICS, INC.

                                  CERTIFICATION

In connection  with the periodic report of Protalix  BioTherapeutics,  Inc. (the
"Company") on Form 10-K for the period ended December 31, 2006 as filed with the
Securities and Exchange Commission (the "Report"),  I, David Aviezer,  President
and Chief  Executive  Officer  of the  Company,  hereby  certify  as of the date
hereof,  solely for purposes of Title 18, Chapter 63, Section 1350 of the United
States Code, that to the best of my knowledge:

      (1) the Report fully  complies with the  requirements  of Section 13(a) or
      15(d), as applicable, of the Securities Exchange Act of 1934; and

      (2) the  information  contained  in the  Report  fairly  presents,  in all
      material  respects,  the financial  condition and results of operations of
      the Company at the dates and for the periods indicated.

This  Certification  has not been,  and shall not be  deemed,  "filed"  with the
Securities and Exchange Commission.

Date: March 28, 2007

/s/ David Aviezer
-----------------------------------------------
David Aviezer, Ph.D.
President and Chief Executive Officer
</TEXT>
</DOCUMENT>
