<DOCUMENT>
<TYPE>EX-32.2
<SEQUENCE>13
<FILENAME>e26589ex32_2.txt
<DESCRIPTION>CERTIFICATION
<TEXT>
                                                                    EXHIBIT 32.2

                         PROTALIX BIOTHERAPEUTICS, INC.

                                  CERTIFICATION
                                  -------------

In connection  with the periodic report of Protalix  BioTherapeutics,  Inc. (the
"Company") on Form 10-K for the period ended December 31, 2006 as filed with the
Securities  and  Exchange  Commission  (the  "Report"),  I, Yossi  Maimon,  Vice
President and Chief Financial  Officer of the Company,  hereby certify as of the
date hereof,  solely for the purposes of Title 18,  Chapter 63,  Section 1350 of
the United States Code, that to the best of my knowledge:

      (1) the Report fully  complies with the  requirements  of Section 13(a) or
      15(d), as applicable, of the Securities Exchange Act of 1934; and

      (2) the  information  contained  in the  Report  fairly  presents,  in all
      material  respects,  the financial  condition and results of operations of
      the Company at the dates and for the periods indicated.

      This Certification has not been, and shall not be deemed, "filed" with the
      Securities and Exchange Commission.

Date: March 28, 2007

/s/ Yossi Maimon
------------------------------------------------
Yossi Maimon
Vice President and Chief Financial Officer
</TEXT>
</DOCUMENT>
