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<SEC-DOCUMENT>0000950136-07-006589.txt : 20070924
<SEC-HEADER>0000950136-07-006589.hdr.sgml : 20070924
<ACCEPTANCE-DATETIME>20070924143616
ACCESSION NUMBER:		0000950136-07-006589
CONFORMED SUBMISSION TYPE:	S-3/A
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20070924
DATE AS OF CHANGE:		20070924

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Protalix BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001006281
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				650643773
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-144801
		FILM NUMBER:		071131318

	BUSINESS ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			21000
		BUSINESS PHONE:		972-4-988-9488

	MAIL ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			21000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORTHODONTIX INC
		DATE OF NAME CHANGE:	19980422

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EMBASSY ACQUISITION CORP
		DATE OF NAME CHANGE:	19960124
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3/A
<SEQUENCE>1
<FILENAME>file1.htm
<DESCRIPTION>AMENDMENT NO. 2 TO FORM S-3
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<a name="page"></a><font style="font-family:serif;font-weight:normal;color:#000000;font-size:8pt;  text-align: left; font-style: normal; line-height: 10pt; background-color: #ffffff"><a href="#toc">Table of Contents</a></font>
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<font style="opacity:100; position:relative; ">As filed with the Securities and Exchange Commission on September&nbsp;24,&nbsp;2007</font>
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<font style="opacity:100; position:relative; ">Registration No. 333-144801</font>
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<font style="opacity:100; position:relative; ">UNITED STATES</font>
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<font style="opacity:100; position:relative; ">SECURITIES AND EXCHANGE COMMISSION</font>
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<font style="opacity:100; position:relative; font-size:10pt;">Washington, D.C. 20549</font>
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<font style="opacity:100; position:relative; ">AMENDMENT NO. 2 TO FORM S-3</font>
<br>
<font style="opacity:100; position:relative; font-size:10pt;">REGISTRATION STATEMENT </font><font style="opacity:100; position:relative; font-size:10pt;font-variant:none; text-transform:uppercase;">Under </font><font style="opacity:100; position:relative; font-size:10pt;">THE SECURITIES ACT OF 1933</font>
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<font style="opacity:100; position:relative; ">Protalix BioTherapeutics, Inc.</font>
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<p style="font-family:serif;font-weight:normal;color:#000000;font-size:8pt;  width: 528pt; text-align: center; font-style: normal; line-height: 10pt; padding-top: 6pt; padding-left:0pt; padding-right:0pt; margin: 0pt; text-indent: pt; padding-bottom: 6pt; background-color: #ffffff;">
<font style="opacity:100; position:relative; ">(Exact name of registrant as specified in its Charter)</font>
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<td style="font-size: 10pt; line-height:12pt; color: #000000; border-bottom: 1px solid #ffffff;padding-top: 0pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="1"><font style="font-family: serif; font-size: 10pt; line-height:12pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Florida</font></font></td>
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<td style="font-size: 10pt; line-height:12pt; color: #000000; border-bottom: 1px solid #ffffff;padding-top: 0pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="1"><font style="font-family: serif; font-size: 10pt; line-height:12pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">65-0643773</font></font></td>
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<font style="opacity:100; position:relative; ">of incorporation or organization)</font></font></td>
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<font style="opacity:100; position:relative; ">Identification Number)</font></font></td>
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<font style="opacity:100; position:relative; ">2 Snunit Street</font>
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<font style="opacity:100; position:relative; ">Science Park</font>
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<font style="opacity:100; position:relative; ">POB 455</font>
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<font style="opacity:100; position:relative; ">Carmiel, Israel 20100</font>
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<font style="opacity:100; position:relative; ">972-4-988-9488</font>
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<font style="opacity:100; position:relative; ">(Address, including zip code, and telephone number, including area code, of registrant&rsquo;s principal executive offices)</font>
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<font style="opacity:100; position:relative; ">CT Corporation System</font>
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<font style="opacity:100; position:relative; "> 111 Eighth Avenue</font>
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<font style="opacity:100; position:relative; "> New York, NY 10011</font>
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<font style="opacity:100; position:relative; "> Tel: (212)&nbsp;894-8400</font>
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<font style="opacity:100; position:relative; ">(Name, address, including zip code, and telephone number, including area code, of agent for service)</font>
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<font style="opacity:100; position:relative; font-weight: bold; font-style: italic;">With a Copy to:</font>
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<font style="opacity:100; position:relative; ">James R. Tanenbaum, Esq.</font>
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<font style="opacity:100; position:relative; ">Morrison &amp; Foerster LLP</font>
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<font style="opacity:100; position:relative; ">1290 Avenue of the Americas</font>
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<font style="opacity:100; position:relative; ">New York, New York 10104</font>
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<font style="opacity:100; position:relative; ">(212) 468-8000</font>
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<font style="opacity:100; position:relative; ">Approximate date of commencement of proposed sale to the public:</font>
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<font style="opacity:100; position:relative; font-weight: normal;font-style:normal;">From time to time after the effective date of this Registration Statement.</font>
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<font style="opacity:100; position:relative; ">If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box.&nbsp;&nbsp;&nbsp;</font><img src="ebox.gif" alt="[ ]" width="10" height="10"></p>
<p style="font-family:serif;font-weight:normal;color:#000000;font-size:8pt;  width: 528pt; text-align: left; font-style: normal; line-height: 10pt; padding-top:6pt; padding-left:0pt; padding-right:0pt; padding-bottom: 0pt; margin: 0pt; text-indent: 20pt; background-color: #ffffff">
<font style="opacity:100; position:relative; ">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box.&nbsp;&nbsp;&nbsp;</font><img src="cbox.gif" alt="[X]" width="10" height="10"></p>
<p style="font-family:serif;font-weight:normal;color:#000000;font-size:8pt;  width: 528pt; text-align: left; font-style: normal; line-height: 10pt; padding-top:6pt; padding-left:0pt; padding-right:0pt; padding-bottom: 0pt; margin: 0pt; text-indent: 20pt; background-color: #ffffff">
<font style="opacity:100; position:relative; ">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.&nbsp;&nbsp;&nbsp;</font><img src="ebox.gif" alt="[ ]" width="10" height="10"></p>
<p style="font-family:serif;font-weight:normal;color:#000000;font-size:8pt;  width: 528pt; text-align: left; font-style: normal; line-height: 10pt; padding-top:6pt; padding-left:0pt; padding-right:0pt; padding-bottom: 0pt; margin: 0pt; text-indent: 20pt; background-color: #ffffff">
<font style="opacity:100; position:relative; ">If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.&nbsp;&nbsp;&nbsp;</font><img src="ebox.gif" alt="[ ]" width="10" height="10"></p>
<p style="font-family:serif;font-weight:normal;color:#000000;font-size:8pt;  width: 528pt; text-align: left; font-style: normal; line-height: 10pt; padding-top:6pt; padding-left:0pt; padding-right:0pt; padding-bottom: 0pt; margin: 0pt; text-indent: 20pt; background-color: #ffffff">
<font style="opacity:100; position:relative; ">If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box.&nbsp;&nbsp;&nbsp;</font><img src="ebox.gif" alt="[ ]" width="10" height="10"></p>
<p style="font-family:serif;font-weight:normal;color:#000000;font-size:8pt;  width: 528pt; text-align: left; font-style: normal; line-height: 10pt; padding-top:6pt; padding-left:0pt; padding-right:0pt; padding-bottom: 0pt; margin: 0pt; text-indent: 20pt; background-color: #ffffff">
<font style="opacity:100; position:relative; ">If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box.&nbsp;&nbsp;&nbsp;</font><img src="ebox.gif" alt="[ ]" width="10" height="10"></p>
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<font style="opacity:100; position:relative; ">CALCULATION OF REGISTRATION FEE</font>
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<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="25"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">&nbsp;&nbsp;&nbsp;&nbsp;</font></font></td>
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<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 7pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="1"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Title of each class of</font>
<br>
<font style="opacity:100; position:relative; ">securities to be registered</font></font></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 7pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="4"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Amount to be</font>
<br>
<font style="opacity:100; position:relative; ">registered</font><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">(1)</font></sup></font></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 7pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="4"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Proposed maximum</font>
<br>
<font style="opacity:100; position:relative; ">aggregate offering</font>
<br>
<font style="opacity:100; position:relative; ">price per share</font><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">(2)</font></sup></font></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 7pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="4"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Proposed maximum</font>
<br>
<font style="opacity:100; position:relative; ">aggregate offering</font>
<br>
<font style="opacity:100; position:relative; ">price</font><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">(2)</font></sup></font></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 7pt; background-color: #ffffff;	" align="center" valign="bottom" colspan="4"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: bold; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Amount of</font>
<br>
<font style="opacity:100; position:relative; ">registration</font>
<br>
<font style="opacity:100; position:relative; ">fee</font><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">(3)</font></sup></font></td>
</tr>
<tr>
<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-left: 10pt; text-indent: -10pt; padding-top: 0pt; background-color: #ffffff;	" align="left" valign="bottom" colspan="1"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: normal; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Common stock, par value $0.001 per share</font></font></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><img src="spacer.gif" width="1"></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">3,726,708</font><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">(4</font></sup></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><font style="position:absolute;white-space:nowrap;line-height:10pt"><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">)</font></sup></font>&nbsp;
								</td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><font style="opacity:100; position:relative; ">$</font></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">35</font></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><img src="spacer.gif" width="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><font style="opacity:100; position:relative; ">$</font></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">130,434,783</font></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><img src="spacer.gif" width="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 1px solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><font style="opacity:100; position:relative; ">$</font></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">4,004</font></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 1px solid #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><img src="spacer.gif" width="1"></td>
</tr>
<tr>
<td style="font-size: 8pt; line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-left: 10pt; text-indent: -10pt; padding-top: 0pt; background-color: #ffffff;	" align="left" valign="bottom" colspan="1"><font style="font-family: serif; font-size: 8pt; line-height:10pt; color: #000000; font-weight: normal; font-style: normal;background-color: #ffffff;"><font style="opacity:100; position:relative; ">Common stock, par value $0.001 per share</font></font></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><img src="spacer.gif" width="1"></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">1,987,578</font><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">(5</font></sup></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><font style="position:absolute;white-space:nowrap;line-height:10pt"><sup style="vertical-align:top;"><font style="opacity:100; position:relative; ">)</font></sup></font>&nbsp;
								</td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><font style="opacity:100; position:relative; ">$</font></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">35</font></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><img src="spacer.gif" width="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><font style="opacity:100; position:relative; ">$</font></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">69,565,217</font></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><img src="spacer.gif" width="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000; border-right: .5pt solid #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000;"><img src="spacer.gif" width="1" height="1"></td>
<td style="background-color: #ffffff;border-bottom: 3px double #000000"><img src="spacer.gif" width="1" height="1"></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal;" align="right" valign="bottom"><font style="opacity:100; position:relative; ">$</font></td>
<td align="right" style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff;font-weight: normal; font-style: normal; " valign="bottom"><font style="opacity:100; position:relative; ">2,136</font></td>
<td style="font-size: 8pt;  line-height:10pt; color: #000000; border-bottom: 3px double #000000;padding-top: 0pt; background-color: #ffffff; font-weight: normal; font-style: normal; " valign="bottom" align="left"><img src="spacer.gif" width="1"></td>
</tr>
</table>
</div>
</div>
<table cellpadding="0" cellspacing="0" border="0" width="697">
<tr>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: 18pt; padding-left: 0pt;"><font style="opacity:100; position:relative; ">(1)</font></td>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: pt; "><font style="opacity:100; position:relative; ">Pursuant to Rule 416 under the Securities Act of 1933, as amended, the shares being registered hereunder also include such indeterminate number of shares of common stock as may be issuable with respect to the shares being registered hereunder as a result of stock splits, stock dividends or similar transactions.</font></td>
</tr>
</table>
<table cellpadding="0" cellspacing="0" border="0" width="697">
<tr>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: 18pt; padding-left: 0pt;"><font style="opacity:100; position:relative; ">(2)</font></td>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: pt; "><font style="opacity:100; position:relative; ">Estimated solely for the purpose of determining the registration fee pursuant to Rule 457(c) under the Securities Act based upon the average of the high and low prices for the common stock of Protalix BioTherapeutics, Inc. on September 18, 2007, as reported by the American Stock Exchange.</font></td>
</tr>
</table>
<table cellpadding="0" cellspacing="0" border="0" width="697">
<tr>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: 18pt; padding-left: 0pt;"><font style="opacity:100; position:relative; ">(3)</font></td>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: pt; "><font style="opacity:100; position:relative; ">Previously paid.</font></td>
</tr>
</table>
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<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: 18pt; padding-left: 0pt;"><font style="opacity:100; position:relative; ">(4)</font></td>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: pt; "><font style="opacity:100; position:relative; ">For sale by Protalix BioTherapeutics, Inc.</font></td>
</tr>
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<tr>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: 18pt; padding-left: 0pt;"><font style="opacity:100; position:relative; ">(5)</font></td>
<td align="left" valign="top" style="font-family:serif;font-weight:normal;color:#000000;font-size: 8pt; padding-bottom: 6pt;   width: pt; "><font style="opacity:100; position:relative; ">For sale by selling securityholders.</font></td>
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<font style="opacity:100; position:relative; font-weight: bold;font-style:normal;">The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment that specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until this Registration Statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a), may determine.</font>
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<font style="opacity:100; position:relative; ">EXPLANATORY NOTE</font>
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<p style="font-family:serif;font-weight:normal;color:#000000;font-size:10pt;  width: 456pt; text-align: left; font-style: normal; line-height: 12pt; padding-top:6pt; padding-left:0pt; padding-right:0pt; padding-bottom: 6pt; margin: 0pt; text-indent: 0pt; background-color: #ffffff">
<font style="opacity:100; position:relative; ">This Amendment No. 2 to the Registration Statement on Form S-3 (the &lsquo;&lsquo;Form S-3&rsquo;&rsquo;) of Protalix BioTherapeutics, Inc. is being filed solely for the purpose of amending Exhibit 23.2 which was filed with Amendment No. 1 to the Form S-3, filed on September&nbsp;24,&nbsp;2007. Other than the amendment of the exhibit, the remainder of the Form S-3, as amended by Amendment No. 1, is unchanged. Accordingly, the prospectus that forms a part of Amendment No. 1 is not reproduced in this Amendment No. 2. This Amendment No.&nbsp;2 speaks as of the original filing date of Amendment No.&nbsp;1 and does not reflect events occurring after the filing date of Amendment No.&nbsp;1, or modify or update the disclosures therein in any way other than as required to reflect the amendment set forth below.</font>
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<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>2
<FILENAME>file2.htm
<DESCRIPTION>CONSENT
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<p style="font-family:serif;font-weight:bold;color:#000000;font-size:10pt;  width: 456pt; text-align: right; font-style: normal; line-height: 12pt; padding-top: 12pt; padding-left:0pt; padding-right:0pt; margin: 0pt; text-indent: 0pt; padding-bottom: 6pt; background-color: #ffffff;">
<font style="opacity:100; position:relative; ">Exhibit 23.2</font>
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<td style="font-family: serif; font-size: 10pt; color: #000000; font-weight: normal; font-style: normal; padding-top: 6pt;" valign="top" align="left"><font style="opacity:100; position:relative; font-weight: bold;font-style:normal;">Kesselman &amp; Kesselman</font>
<br>
<font style="opacity:100; position:relative; "> Certified Public Accountants (Isr.)</font>
<br>
<font style="opacity:100; position:relative; "> Trade Tower, 25 Hamered Street</font>
<br>
<font style="opacity:100; position:relative; "> Tel Aviv 68125 Israel</font>
<br>
<font style="opacity:100; position:relative; "> P.O. Box 452 Tel Aviv 61003 Israel</font>
<br>
<font style="opacity:100; position:relative; "> Telephone +972-3-7954555</font>
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<font style="opacity:100; position:relative; "> Facsimile +972-3-7954556</font></td>
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<font style="opacity:100; position:relative; ">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</font>
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<font style="opacity:100; position:relative; ">We hereby consent to the incorporation by reference in this Amendment No. 1 to the Registration Statement on Form S-3 of our report dated March&nbsp;30,&nbsp;2007 relating to the financial statements which appears in Protalix BioTherapeutics, Inc.&rsquo;s Annual Report on Form 10-K/A for the year ended December&nbsp;31,&nbsp;2006. We also consent to the references to us under the headings &lsquo;&lsquo;Experts&rsquo;&rsquo; in such Registration Statement.</font>
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<font style="opacity:100; position:relative; ">/s/ Kesselman &amp; Kesselman,</font>
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<p style="font-family:serif;font-weight:normal;color:#000000;font-size:10pt;  width: 456pt; text-align: left; font-style: normal; line-height: 12pt; padding-top:6pt; padding-left:0pt; padding-right:0pt; padding-bottom: 6pt; margin: 0pt; text-indent: 0pt; background-color: #ffffff">
<font style="opacity:100; position:relative; ">Tel Aviv, Israel&nbsp;&nbsp;&nbsp;&nbsp;</font>
<br>
<font style="opacity:100; position:relative; ">September 21,&nbsp;2007</font>
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`
end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
