<SEC-DOCUMENT>0001085146-15-000613.txt : 20150218
<SEC-HEADER>0001085146-15-000613.hdr.sgml : 20150216
<ACCEPTANCE-DATETIME>20150217082342
ACCESSION NUMBER:		0001085146-15-000613
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20150217
DATE AS OF CHANGE:		20150217

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Protalix BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001006281
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				650643773
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-50118
		FILM NUMBER:		15618046

	BUSINESS ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			20100
		BUSINESS PHONE:		972-4-988-9488

	MAIL ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			20100

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORTHODONTIX INC
		DATE OF NAME CHANGE:	19980422

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EMBASSY ACQUISITION CORP
		DATE OF NAME CHANGE:	19960124

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Consonance Capital Management LP
		CENTRAL INDEX KEY:			0001544773
		IRS NUMBER:				260294313
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		1370 AVENUE OF THE AMERICAS
		STREET 2:		SUITE 3301
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		212.660-8062

	MAIL ADDRESS:	
		STREET 1:		1370 AVENUE OF THE AMERICAS
		STREET 2:		SUITE 3301
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>plx_21315.htm
<DESCRIPTION>CONSONANCE CAPITAL MANAGEMENT LP
<TEXT>
<html>
  <head>
    <title></title>
  </head>
  <body>
          <div id="body">
        <div class="form">
          <div class="form">
            <div class="form13G">
              <div style="width:900px;text-align:center !important;font-family:Georgia,'Times New Roman',Times,serif;margin:20px 0px 20px 0px !important;border-bottom:3px solid gray;">
                <h3 style="font-weight:bold;margin:0px !important;padding:0px !important;font-size:16px;">UNITED STATES
	SECURITIES AND EXCHANGE COMMISSION</h3>
                                  <b>Washington, D.C.  20549</b>
                                <h3 style="margin:20px 0px 20px 0px !important;">SCHEDULE 13G</h3>
                <p style="font-weight:bold">
		Under the Securities Exchange Act of 1934
		(Amendment No. )*</p>
                <p>
                                      <b>Protalix BioTherapeutics, Inc.</b>
                  		(Name of Issuer)
	</p>
                <p>
                                      <b>Common Stock, par value $0.001 per share</b>
                  (Title of Class of Securities)
	</p>
                <p>
                                      <b>74365A101</b>
                  		(CUSIP Number)
	</p>
                <p>
                                      <b>December 31, 2014</b>
                  		(Date of Event which Requires Filing of this Statement)
	</p>
                <p style="text-align:left;">
		Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
	</p>
                <p>
		[X]&nbsp;Rule 13d-1(b)		[&nbsp;&nbsp;&nbsp;]&nbsp;Rule 13d-1(c)		[&nbsp;&nbsp;&nbsp;]&nbsp;Rule 13d-1(d)</p>
                <p style="text-align:left;">
		* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the
		subject class of securities, and for any subsequent amendment containing information which would alter the disclosures
		provided in a prior cover page.
	</p>
                <p style="text-align:left;margin-bottom:10px">
		The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of
		the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject
		to all other provisions of the Act (however, see Instructions).
	</p>
              </div>
              <div id="ctl00_cp_personListSubmit_ctrl0_itm" class="pageBreak">
                <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;border-bottom:3px solid gray;margin:0px 0px 0px 0px;">
                  <div style="width:160px;border:solid 1px #000;margin-bottom:10px;display:inline-block;padding:5px 20px 5px 20px;white-space:nowrap;font-weight:bold;font-size:14px;">
	CUSIP No.: 74365A101
</div>
                  <table cellpadding="5" cellspacing="0" style="margin-bottom:10px;border:1px solid black;Width:100%">
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000;padding:0px auto 0px auto">1</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			NAME OF REPORTING PERSON
			Consonance Capital Management LP

			I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">2</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
			(a)&nbsp; [&nbsp;&nbsp;&nbsp;]
			(b)&nbsp; [&nbsp;&nbsp;&nbsp;]
		</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">3</td>
                      <td colspan="3" style="border-bottom:1px solid #000">SEC USE ONLY&nbsp;</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">4</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CITIZENSHIP OR PLACE OF ORGANIZATION
			Delaware
		</td>
                    </tr>
                    <tr>
                      <td colspan="2" rowspan="4" class="text" style="width:140px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">
			NUMBER OF SHARES
			BENEFICIALLY OWNED
			BY EACH REPORTING
			PERSON WITH
		</td>
                      <td colspan="1" style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">5</td>
                      <td colspan="1" style="border-bottom:1px solid #000">
			SOLE VOTING POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">6</td>
                      <td style="border-bottom:1px solid #000">
			SHARED VOTING POWER
			5,027,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">7</td>
                      <td style="border-bottom:1px solid #000">
			SOLE DISPOSITIVE POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">8</td>
                      <td style="border-bottom:1px solid #000">
			SHARED DISPOSITIVE POWER
			5,027,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">9</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
			5,027,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">10</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
			[]
			</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">11</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
			5.4% Based on 93,672,564 shares of common stock outstanding as of November 1, 2014, as reported in the Issuers Form 10-Q filed with the SEC on November 10, 2014.
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;">12</td>
                      <td colspan="3">
			TYPE OF REPORTING PERSON
			IA, PN
		</td>
                    </tr>
                  </table>
                </div>
              </div>
              <div id="ctl00_cp_personListSubmit_ctrl1_itm" class="pageBreak">
                <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;border-bottom:3px solid gray;margin:0px 0px 0px 0px;">
                  <div style="width:160px;border:solid 1px #000;margin-bottom:10px;display:inline-block;padding:5px 20px 5px 20px;white-space:nowrap;font-weight:bold;font-size:14px;">
	CUSIP No.: 74365A101
</div>
                  <table cellpadding="5" cellspacing="0" style="margin-bottom:10px;border:1px solid black;Width:100%">
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000;padding:0px auto 0px auto">1</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			NAME OF REPORTING PERSON
			Consonance Capital Opportunity Fund Management LP

			I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">2</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
			(a)&nbsp; [&nbsp;&nbsp;&nbsp;]
			(b)&nbsp; [&nbsp;&nbsp;&nbsp;]
		</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">3</td>
                      <td colspan="3" style="border-bottom:1px solid #000">SEC USE ONLY&nbsp;</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">4</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CITIZENSHIP OR PLACE OF ORGANIZATION
			Delaware
		</td>
                    </tr>
                    <tr>
                      <td colspan="2" rowspan="4" class="text" style="width:140px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">
			NUMBER OF SHARES
			BENEFICIALLY OWNED
			BY EACH REPORTING
			PERSON WITH
		</td>
                      <td colspan="1" style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">5</td>
                      <td colspan="1" style="border-bottom:1px solid #000">
			SOLE VOTING POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">6</td>
                      <td style="border-bottom:1px solid #000">
			SHARED VOTING POWER
			50,000
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">7</td>
                      <td style="border-bottom:1px solid #000">
			SOLE DISPOSITIVE POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">8</td>
                      <td style="border-bottom:1px solid #000">
			SHARED DISPOSITIVE POWER
			50,000
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">9</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
			50,000
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">10</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
			[]
			</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">11</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
			0.1% Based on 93,672,564 shares of common stock outstanding as of November 1, 2014, as reported in the Issuers Form 10-Q filed with the SEC on November 10, 2014.
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;">12</td>
                      <td colspan="3">
			TYPE OF REPORTING PERSON
			IA, PN
		</td>
                    </tr>
                  </table>
                </div>
              </div>
              <div id="ctl00_cp_personListSubmit_ctrl2_itm" class="pageBreak">
                <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;border-bottom:3px solid gray;margin:0px 0px 0px 0px;">
                  <div style="width:160px;border:solid 1px #000;margin-bottom:10px;display:inline-block;padding:5px 20px 5px 20px;white-space:nowrap;font-weight:bold;font-size:14px;">
	CUSIP No.: 74365A101
</div>
                  <table cellpadding="5" cellspacing="0" style="margin-bottom:10px;border:1px solid black;Width:100%">
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000;padding:0px auto 0px auto">1</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			NAME OF REPORTING PERSON
			Mitchell Blutt

			I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">2</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
			(a)&nbsp; [&nbsp;&nbsp;&nbsp;]
			(b)&nbsp; [&nbsp;&nbsp;&nbsp;]
		</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">3</td>
                      <td colspan="3" style="border-bottom:1px solid #000">SEC USE ONLY&nbsp;</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">4</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CITIZENSHIP OR PLACE OF ORGANIZATION
			USA
		</td>
                    </tr>
                    <tr>
                      <td colspan="2" rowspan="4" class="text" style="width:140px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">
			NUMBER OF SHARES
			BENEFICIALLY OWNED
			BY EACH REPORTING
			PERSON WITH
		</td>
                      <td colspan="1" style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">5</td>
                      <td colspan="1" style="border-bottom:1px solid #000">
			SOLE VOTING POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">6</td>
                      <td style="border-bottom:1px solid #000">
			SHARED VOTING POWER
			5,077,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">7</td>
                      <td style="border-bottom:1px solid #000">
			SOLE DISPOSITIVE POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">8</td>
                      <td style="border-bottom:1px solid #000">
			SHARED DISPOSITIVE POWER
			5,077,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">9</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
			5,077,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">10</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
			[]
			</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">11</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
			5.4% Based on 93,672,564 shares of common stock outstanding as of November 1, 2014, as reported in the Issuers Form 10-Q filed with the SEC on November 10, 2014.
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;">12</td>
                      <td colspan="3">
			TYPE OF REPORTING PERSON
			HC, IN
		</td>
                    </tr>
                  </table>
                </div>
              </div>
              <div id="ctl00_cp_personListSubmit_ctrl3_itm" class="pageBreak">
                <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;border-bottom:3px solid gray;margin:0px 0px 0px 0px;">
                  <div style="width:160px;border:solid 1px #000;margin-bottom:10px;display:inline-block;padding:5px 20px 5px 20px;white-space:nowrap;font-weight:bold;font-size:14px;">
	CUSIP No.: 74365A101
</div>
                  <table cellpadding="5" cellspacing="0" style="margin-bottom:10px;border:1px solid black;Width:100%">
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000;padding:0px auto 0px auto">1</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			NAME OF REPORTING PERSON
			Consonance Capman GP LLC

			I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">2</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
			(a)&nbsp; [&nbsp;&nbsp;&nbsp;]
			(b)&nbsp; [&nbsp;&nbsp;&nbsp;]
		</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">3</td>
                      <td colspan="3" style="border-bottom:1px solid #000">SEC USE ONLY&nbsp;</td>
                    </tr>
                    <tr>
                      <td colspan="1" style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">4</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CITIZENSHIP OR PLACE OF ORGANIZATION
			Delaware
		</td>
                    </tr>
                    <tr>
                      <td colspan="2" rowspan="4" class="text" style="width:140px;text-align:center;border-right:1px solid #000;border-bottom:1px solid #000">
			NUMBER OF SHARES
			BENEFICIALLY OWNED
			BY EACH REPORTING
			PERSON WITH
		</td>
                      <td colspan="1" style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">5</td>
                      <td colspan="1" style="border-bottom:1px solid #000">
			SOLE VOTING POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">6</td>
                      <td style="border-bottom:1px solid #000">
			SHARED VOTING POWER
			5,077,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">7</td>
                      <td style="border-bottom:1px solid #000">
			SOLE DISPOSITIVE POWER
			0
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">8</td>
                      <td style="border-bottom:1px solid #000">
			SHARED DISPOSITIVE POWER
			5,077,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">9</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
			5,077,338
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">10</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
			[]
			</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;border-bottom:1px solid #000">11</td>
                      <td colspan="3" style="border-bottom:1px solid #000">
			PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
			5.4% Based on 93,672,564 shares of common stock outstanding as of November 1, 2014, as reported in the Issuers Form 10-Q filed with the SEC on November 10, 2014.
		</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;width:90px;text-align:center;border-right:1px solid black;">12</td>
                      <td colspan="3">
			TYPE OF REPORTING PERSON
			HC, OO
		</td>
                    </tr>
                  </table>
                </div>
              </div>
              <div class="pageBreak" style="border-bottom:none;">
                <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;margin:0px 0px 20px 0px;">
                  <div style="width:160px;border:solid 1px #000;margin-bottom:10px;display:inline-block;padding:5px 20px 5px 20px;white-space:nowrap;font-weight:bold;font-size:14px;">
		CUSIP No.: 74365A101
	</div>
                  <table cellpadding="2" cellspacing="0" border="0">
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 1(a).</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">NAME OF ISSUER:</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">Protalix BioTherapeutics, Inc.</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 1(b).</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">2 Snunit StreetScience ParkP.O. Box 455Carmiel, Israel 20100</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 2(a).</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">NAME OF PERSON FILING:</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">Consonance Capital Management LP Consonance Capital Opportunity Fund Management LPMitchell Blutt Consonance Capman GP LLC </td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 2(b).</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">1370 Avenue of the AmericaSuite 3301New York, NY 10019</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 2(c).</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">CITIZENSHIP:</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">Consonance Capital Management LP  - DelawareConsonance Capital Opportunity Fund Management LP - DelawareMitchell Blutt  - USAConsonance Capman GP LLC  - Delaware</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 2(d).</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">TITLE OF CLASS OF SECURITIES:</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">Common Stock, par value $0.001 per share</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 2(e).</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">CUSIP NUMBER:</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">74365A101</td>
                    </tr>
                  </table>
                  <table cellpadding="2" cellspacing="0" border="0" style="margin:0px 0px 10px 0px">
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 3.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;padding:0px 0px 5px 0px;">
				IF THIS STATEMENT IS FILED PURSUANT TO SECTION 240.13d-1(b), or 13d-2(b) or (c)
				CHECK WHETHER THE PERSON FILING IS A:
			</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top;">(a)</td>
                      <td>[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78c);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(b)</td>
                      <td>[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(c)</td>
                      <td>[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;Insurance company as defined in Section 3(a)(19) of the Act (15 U.S.C. 78c);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(d)</td>
                      <td>[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;Investment company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(e)</td>
                      <td>[X]&nbsp;&nbsp;An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(f)</td>
                      <td>[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;An employee benefit plan or endowment fund in accordance with 240.13d-1(b)(1)(ii)(F);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(g)</td>
                      <td>[X]&nbsp;&nbsp;A parent holding company or control person in accordance with 240.13d-1(b)(1)(ii)(G);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(h)</td>
                      <td>[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(i)</td>
                      <td>[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(j)</td>
                      <td>
				[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;A non-U.S. institution in accordance with 240.13d-1(b)(1)(ii)(J);

			</td>
                    </tr>
                    <tr>
                      <td style="vertical-align:top">(k)</td>
                      <td>
				[&nbsp;&nbsp;&nbsp;]&nbsp;&nbsp;Group, in accordance with 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with 240.13d1(b)(1)(ii)(J), please specify the type of institution:

			</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:10px 0px 0px 5px;">ITEM 4.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:10px 0px 5px 0px;">
				OWNERSHIP:
			</td>
                    </tr>
                    <tr>
                      <td colspan="2">
				Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
			</td>
                    </tr>
                    <tr>
                      <td>(a)</td>
                      <td>Amount beneficially owned:</td>
                    </tr>
                    <tr>
                      <td>Consonance Capital Management LP  5,027,338 Consonance Capital Opportunity Fund Management LP  50,000 Mitchell Blutt  5,077,338 Consonance Capman GP LLC  5,077,338 </td>
                    </tr>
                    <tr>
                      <td>(b)</td>
                      <td>Percent of class:</td>
                    </tr>
                    <tr>
                      <td>Consonance Capital Management LP  5.4%Consonance Capital Opportunity Fund Management LP  0.1%Mitchell Blutt  5.4%Consonance Capman GP LLC  5.4%Based on 93,672,564 shares of common stock outstanding as of November 1, 2014, as reported in the Issuers Form 10-Q filed with the SEC on November 10, 2014.</td>
                    </tr>
                    <tr>
                      <td>(c)</td>
                      <td>Number of shares as to which the person has:</td>
                    </tr>
                    <tr>
                      <td style="padding-top:0px;">(i)&nbsp;&nbsp;&nbsp;Sole power to vote or to direct the vote: </td>
                    </tr>
                    <tr>
                      <td style="padding:0px 0px 0px 32px">Consonance Capital Management LP  - 0Consonance Capital Opportunity Fund Management LP - 0Mitchell Blutt  - 0Consonance Capman GP LLC  - 0</td>
                    </tr>
                    <tr>
                      <td>(ii)&nbsp;&nbsp;Shared power to vote or to direct the vote: </td>
                    </tr>
                    <tr>
                      <td style="padding:0px 0px 0px 32px">Consonance Capital Management LP  5,027,338 Consonance Capital Opportunity Fund Management LP  50,000 Mitchell Blutt  5,077,338 Consonance Capman GP LLC  5,077,338</td>
                    </tr>
                    <tr>
                      <td>(iii) Sole power to dispose or to direct the disposition of:</td>
                    </tr>
                    <tr>
                      <td style="padding:0px 0px 0px 32px">Consonance Capital Management LP  - 0Consonance Capital Opportunity Fund Management LP - 0Mitchell Blutt  - 0Consonance Capman GP LLC  - 0</td>
                    </tr>
                    <tr>
                      <td>(iv) Shared power to dispose or to direct the disposition of: </td>
                    </tr>
                    <tr>
                      <td style="padding:0px 0px 0px 32px">Consonance Capital Management LP  5,027,338 Consonance Capital Opportunity Fund Management LP  50,000 Mitchell Blutt  5,077,338 Consonance Capman GP LLC  5,077,338</td>
                    </tr>
                  </table>
                  <table cellpadding="2" cellspacing="0" border="0">
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 5.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">
				OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:
			</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [&nbsp;&nbsp;&nbsp;].</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 6.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">
				OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:
			</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">The ownership information in Item 4 is incorporated herein by reference. &nbsp;</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 7.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">
				IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY:
			</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15x 5px;"> Not applicable. &nbsp;</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 8.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">
				IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:
			</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;"> Not applicable. &nbsp;</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 9.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">
				NOTICE OF DISSOLUTION OF GROUP:
			</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;"> Not applicable. &nbsp;</td>
                    </tr>
                    <tr>
                      <td style="width:102px;vertical-align:top;font-weight:bold;padding:0px 0px 0px 5px;">ITEM 10.</td>
                      <td colspan="2" style="vertical-align:top;font-weight:bold;text-transform:uppercase;padding:0px 0px 5px 0px;">
				CERTIFICATION:
			</td>
                    </tr>
                    <tr>
                      <td colspan="2" style="padding:0px 0px 15px 5px;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.</td>
                    </tr>
                  </table>
                </div>
              </div>
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                    <div id="ctl00_cp_signerSubmitList_ctrl0_signerSubmit_banner">
                      <h3 style="text-align:center;padding:0px 0px 20px 0px !important;">SIGNATURE</h3>
                      <div style="padding:0px 170px 35px 170px;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
                    </div>
                    <table cellpadding="0" cellspacing="0" border="0" style="text-align:center">
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				February 13, 2015
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Date</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>
				CONSONANCE CAPITAL MANAGEMENT LPBy:  Consonance Capman GP LLC
			</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				/s/ Mitchell Blutt
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Signature</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				Mitchell Blutt, Manager &amp; Member
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Name/Title</td>
                      </tr>
                    </table>
                  </div>
                </div>
                <div id="ctl00_cp_signerSubmitList_ctrl1_itm">
                  <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;">
                    <table cellpadding="0" cellspacing="0" border="0" style="text-align:center">
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                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				February 13, 2015
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Date</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>
				CONSONANCE CAPITAL OPPORTUNITY FUND MANAGEMENT LPBy:  Consonance Capman GP LLC
			</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				/s/ Mitchell Blutt
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Signature</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				Mitchell Blutt, Manager &amp; Member
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Name/Title</td>
                      </tr>
                    </table>
                  </div>
                </div>
                <div id="ctl00_cp_signerSubmitList_ctrl2_itm">
                  <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;">
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                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				February 13, 2015
			</td>
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                      <tr style="padding:0px 0px 20px 0px">
                        <td>Date</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>
				CONSONANCE CAPITAL MANAGEMENT LPBy:  Consonance Capman GP LLC
			</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				/s/ Mitchell Blutt
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Signature</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				Mitchell Blutt, Manager &amp; Member
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Name/Title</td>
                      </tr>
                    </table>
                  </div>
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                  <div style="font-family:Georgia,'Times New Roman',Times,serif;width:900px;">
                    <table cellpadding="0" cellspacing="0" border="0" style="text-align:center">
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                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				February 13, 2015
			</td>
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                      <tr style="padding:0px 0px 20px 0px">
                        <td>Date</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>
				Mitchell Blutt
			</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				/s/Mitchell Blutt
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Signature</td>
                      </tr>
                      <tr>
                        <td style="width:900px ;vertical-align:top;text-align:center;padding:0px auto 0px auto;">
				Mitchell Blutt , Manager &amp; Member
			</td>
                      </tr>
                      <tr style="padding:0px 0px 20px 0px">
                        <td>Name/Title</td>
                      </tr>
                    </table>
                  </div>
                  <div id="ctl00_cp_signerSubmitList_ctrl3_signerSubmit_divDis" class="disclaimer">
			Attention: Intentional misstatements or omissions of fact constitute Federal criminal violations (see 18 U.S.C. 1001).
	</div>
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                  <div class="attachment">
                    <div id="ctl00_cp_exhibitList_ctrl0_exhibit_cusipDiv" class="cusip">CUSIP No.: 74365A101</div>
                    <div class="body">
		Item 4. Ownership:Consonance Capital Master Account LP (Consonance Master) directly holds 5,027,338 shares of the Issuers Common Stock (the Master Account Shares).  Consonance Capital Management LP (the Adviser) is the investment adviser of Consonance Master, and pursuant to an investment advisory agreement (the Advisory Agreement), the Adviser exercises voting and investment power over the Master Account Shares held by Consonance Master.  Consonance Capman GP LLC (Capman) is the general partner of the Adviser and Mitchell Blutt, as the Manager &amp; Member of Capman and Chief Executive Officer of the Adviser, may be deemed to control Capman and the Adviser.  Each of the Adviser, Capman and Mr. Blutt may be deemed to beneficially own the Master Account Shares, but neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that any of the Adviser, Capman or Mr. Blutt is the beneficial owner of the Master Account Shares for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose.  A managed account managed by Consonance Capital Opportunity Fund Management LP (Consonance Opportunity) directly holds 50,000 shares of the Issuers Common Stock (the Managed Account Shares).  Capman is the general partner of Consonance Opportunity and Mitchell Blutt, as the Manager &amp; Member of Capman, may be deemed to control Capman and Consonance Opportunity.  Each of Consonance Opportunity, Capman and Mr. Blutt may be deemed to beneficially own the Managed Account Shares, but neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that any of Consonance Opportunity, Capman or Mr. Blutt is the beneficial owner of the Managed Account Shares for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose.   EXHIBIT 99.1	JOINT FILING AGREEMENTIn accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13G dated February 13, 2015 (including amendments thereto) with respect to the Common Stock, par value $0.001 per share, of Protalix BioTherapeutics, Inc.  This Joint Filing Agreement shall be filed as an Exhibit to such Statement.  The undersigned acknowledge that each shall be responsible for the timely filing of any amendments to such joint filing and for the completeness and accuracy of the information concerning him or it contained herein and therein, but shall not be responsible for the completeness and accuracy of the information concerning the others.  CONSONANCE CAPITAL MANAGEMENT LPBy:  Consonance Capman GP LLCBy:	/s/ Mitchell BluttName:	Mitchell BluttTitle:	Manager &amp; MemberCONSONANCE CAPITAL OPPORTUNITY FUND MANAGEMENT LPBy:  Consonance Capman GP LLCBy:	/s/ Mitchell BluttName:	Mitchell BluttTitle:	Manager &amp; MemberCONSONANCE CAPMAN GP LLCBy:	/s/ Mitchell BluttName:	Mitchell BluttTitle:	Manager &amp; Member/s/ Mitchell BluttMITCHELL BLUTT</div>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
