<SEC-DOCUMENT>0001144204-15-059259.txt : 20151013
<SEC-HEADER>0001144204-15-059259.hdr.sgml : 20151012
<ACCEPTANCE-DATETIME>20151013172930
ACCESSION NUMBER:		0001144204-15-059259
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20151012
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Results of Operations and Financial Condition
ITEM INFORMATION:		Unregistered Sales of Equity Securities
ITEM INFORMATION:		Other Events
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20151013
DATE AS OF CHANGE:		20151013

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Protalix BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001006281
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				650643773
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33357
		FILM NUMBER:		151156807

	BUSINESS ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			20100
		BUSINESS PHONE:		972-4-988-9488

	MAIL ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			20100

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORTHODONTIX INC
		DATE OF NAME CHANGE:	19980422

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EMBASSY ACQUISITION CORP
		DATE OF NAME CHANGE:	19960124
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>v422102_8-k.htm
<DESCRIPTION>FORM 8-K
<TEXT>
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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>UNITED STATES</B></FONT></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>SECURITIES
AND EXCHANGE COMMISSION</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Washington,
D.C. 20549</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>FORM 8-K</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>CURRENT REPORT
</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Pursuant
to Section 13 or 15(d) of </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>the Securities
Exchange Act of 1934 </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Date of Report
(Date of Earliest Event Reported): October 13, 2015 (October 12, 2015)</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Protalix
BioTherapeutics, Inc.</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>(Exact name
of registrant as specified in its charter) </B></FONT></P>

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    <TD STYLE="width: 32%; font-size: 10pt"><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <TD STYLE="width: 34%; font-size: 10pt"><FONT STYLE="color: Black">&nbsp;</FONT></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>Florida</B></FONT></td>
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>001-33357</B></FONT></td>
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>65-0643773</B></FONT></td></tr>
<tr style="vertical-align: top">
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>(State
        or other jurisdiction of incorporation)</B></FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P></td>
    <TD STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>(Commission File Number)</B></FONT></td>
    <TD><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>(IRS
        Employer Identification No.)</B>&nbsp;</FONT></P></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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    <TD STYLE="width: 50%"><FONT STYLE="color: Black">&nbsp;</FONT></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>2 Snunit Street</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>20100</B></FONT></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>Science Park, POB 455</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>Carmiel, Israel</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>(Address of principal executive offices)</B></FONT></td>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt; color: Black"><B>(Zip Code)</B></FONT></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Registrant's
telephone number, including area code +972-4-988-9488</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>(Former name
or former address, if changed since last report.) </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>



<HR SIZE="1" NOSHADE ALIGN="CENTER" STYLE="width: 17%; color: black">

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">Check the appropriate box below
if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following
provisions (see General Instruction A.2. below):</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font: 10pt Wingdings; color: Black">&uml;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; color: Black">Written
                                         communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</FONT></TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font: 10pt Wingdings; color: Black">&uml;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; color: Black">Soliciting
                                         material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</FONT></TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font: 10pt Wingdings; color: Black">&uml;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; color: Black">Pre-commencement
                                         communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</FONT></TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font: 10pt Wingdings; color: Black">&uml;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt; color: Black">Pre-commencement
                                         communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</FONT></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Item 1.01. Entry into a Material
Definitive Agreement</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">On October 13, 2015, Protalix
BioTherapeutics, Inc. (the &ldquo;Company&rdquo;) announced that its wholly-owned subsidiary, Protalix Ltd.
(&ldquo;Protalix&rdquo;), had entered into an Amended and Restated Exclusive License and Supply Agreement, dated October 12,
2015 (the &ldquo;Amended Agreement&rdquo;), with Pfizer Inc. (&ldquo;Pfizer&rdquo;). The Amended Agreement amends and
restates, in its entirety, that certain Exclusive License and Supply Agreement dated November 30, 2009 by and between
Protalix and Pfizer, as amended on June 18, 2013 (the &ldquo;Original Agreement&rdquo;). Pursuant to the Amended Agreement,
Protalix has sold its share in the collaboration with Pfizer on the commercialization of Elelyso<SUP>TM</SUP> to Pfizer in
exchange for a cash payment equal to $36 million. As part of the sale, Protalix agreed to transfer its rights to Elelyso in
Israel to Pfizer, and has retained rights to Elelyso in Brazil. Under the Original Agreement, Pfizer and Protalix shared in
revenues and expenses for the development and commercialization of Elelyso on a 60%/40% basis globally, excluding Israel and
Brazil. Under the Amended Agreement, Pfizer is responsible for 100% of expenses, and entitled to all of the revenues, globally for
Elelyso, excluding Brazil, where Protalix is responsible for all expenses and retains all revenues. The
Amended Agreement eliminates Pfizer&rsquo;s entitlement to annual payments of up to $12.5 million in relation to
commercialization of Elelyso in Brazil.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">For the first ten year period
after the execution of the Amended Agreement, Protalix shall continue to sell drug substance to Pfizer for the production of
Elelyso, and Pfizer maintains the right to extend the supply period for up to two additional 30-month periods. The Amended
Agreement also includes provisions regarding cooperation for regulatory matters, supply of the drug substance to Pfizer,
including provisions addressing failure to supply, and patent enforcement, and contains customary provisions regarding
termination, indemnification and insurance requirements.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">The Amended Agreement includes a
non-competition covenant which limits Protalix&rsquo;s right to commercialize any drug product or compound for the treatment
of Gaucher disease, other than Protalix&rsquo;s oral formulation, for a specified period and subject to specified exceptions.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">In addition to the foregoing,
the Amended Agreement provides that Protalix shall issue to Pfizer a five-year, non-interest bearing promissory note with a
principal amount equal to approximately $4.3 million for accumulated losses of the collaboration through September 30, 2015.
The note includes standard events of default that result in the acceleration of the note&rsquo;s maturity date. In addition,
the note becomes immediately payable upon certain failures by Protalix to supply drug substance to Pfizer under the Amended
Agreement.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Item 2.02. Results of Operations
and Financial Condition</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">On October 13, 2015, the Company
issued a press release announcing the entry into the Amended Agreement described in Item 1.01. The press release includes certain
information regarding the Company&rsquo;s financial condition as of September 30, 2015. See Item 8.01.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">In accordance with General Instruction
B.2 of Form 8-K, the information regarding the Company&rsquo;s financial condition as of September 30, 2015 in this Current Report
on Form 8-K, including Exhibit 99.1, shall not be deemed to be &ldquo;filed&rdquo; for purposes of Section 18 of the Securities
Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), or otherwise subject to the liability of that section, and
shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933,
as amended (the &ldquo;Securities Act&rdquo;), or the Exchange Act, except as shall be expressly set forth by specific reference
in such filing.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Item 3.02. Unregistered Sales
of Equity Securities</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">On October 12, 2015, the Company
entered into a Stock Purchase Agreement with C.P. Pharmaceuticals International C.V. (the &ldquo;Purchaser&rdquo;), an affiliate
of Pfizer, pursuant to which the Company agreed to sell, and the Purchaser agreed to buy, 5,649,079 shares of the Company&rsquo;s
common stock for an aggregate purchase price equal to $10,000,000 subject to certain other terms set forth in the Stock Purchase
Agreement. The issuance is exempt from registration pursuant to Section 4(a)(2) of the Securities Act. As part of the Stock Purchase
Agreement, Pfizer has agreed to a 180-day lock-up with respect to the purchased shares of common stock and the Company&rsquo;s
directors and executive officers have entered into 90-day lock up agreements.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Item 8.01. Other Events</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">On October 13, 2015, the Company
issued a press release announcing the entry into the Amended Agreement. A copy of the press release is attached as Exhibit 99.1
to this Current Report on Form 8-K and is incorporated herein by reference, except to the extent set forth in Item 2.02.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Item 9.01. Financial Statements
and Exhibits</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in; text-align: left"><FONT STYLE="color: Black"><B>(d)</B></FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="color: Black"><B>Exhibits</B></FONT></TD>
</TR></TABLE>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in; text-align: left"><FONT STYLE="color: Black">99.1</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="color: Black">Press
                                         release dated October 13, 2015.</FONT></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>SIGNATURES</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="color: Black">Pursuant to
the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.</FONT></P>

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<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <td style="vertical-align: top"><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <td colspan="2"><FONT STYLE="color: Black"><B>PROTALIX BIOTHERAPEUTICS, INC.</B></FONT></td></tr>
<tr>
    <td style="vertical-align: top"><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <td colspan="2"><FONT STYLE="color: Black">&nbsp;</FONT></td></tr>
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    <td style="vertical-align: top"><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <td colspan="2"><FONT STYLE="color: Black">&nbsp;</FONT></td></tr>
<tr>
    <td style="vertical-align: top; width: 50%"><FONT STYLE="color: Black">Date: October 13, 2015</FONT></td>
    <td style="width: 5%"><FONT STYLE="font-size: 10pt; color: Black">By:</FONT></td>
    <td style="vertical-align: top; width: 45%; border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt; color: Black">/s/
    Moshe Manor</FONT></td></tr>
<tr>
    <td style="vertical-align: top"><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <td><FONT STYLE="font-size: 10pt; color: Black">Name:</FONT></td>
    <td style="vertical-align: top"><FONT STYLE="color: Black">Moshe Manor</FONT></td></tr>
<tr>
    <td style="vertical-align: top"><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <td><FONT STYLE="color: Black">Title:</FONT></td>
    <td style="vertical-align: top"><FONT STYLE="color: Black">President and Chief Executive Officer</FONT></td></tr>
<tr>
    <td style="vertical-align: top"><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <td><FONT STYLE="color: Black">&nbsp;</FONT></td>
    <td style="vertical-align: top"><FONT STYLE="color: Black">&nbsp;</FONT></td></tr>
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<TYPE>EX-99.1
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<DESCRIPTION>EXHIBIT 99.1
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<P STYLE="margin: 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="margin: 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><FONT STYLE="color: Black">Exhibit 99.1</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Protalix
BioTherapeutics Sells its Share in Collaboration Agreement for ELELYSO and a</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>6% Equity Stake in Protalix to Pfizer for a total
of $46 Million</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B><I>Protalix
to use funds to aggressively push its clinical pipeline forward and execute its new strategy of developing clinically superior
biologics</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B><I>Protalix
receives all rights to ELELYSO in Brazil in exchange for all rights to ELELYSO in Israel</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">CARMIEL,&nbsp;Israel,&nbsp;October
13, 2015&nbsp;--&nbsp;Protalix BioTherapeutics, Inc.&nbsp;(NYSE MKT:PLX) (TASE:PLX), announced today that the Company sold its
share in the collaboration agreement for ELELYSO<FONT STYLE="font-size: 8pt"><SUP>TM </SUP></FONT>to its commercialization partner,
Pfizer Inc. Under the initial collaboration agreement, Pfizer and the Company shared revenues and expenses for the development
and commercialization of ELELYSO on a 60%/40% basis globally, excluding Israel and Brazil. As amended, Pfizer is responsible for
100% of expenses, and entitled to all of the revenues, globally for ELELYSO, excluding Brazil, where the Company will be responsible
for all expenses and retain all revenues.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&ldquo;We are very pleased to have
the support of Pfizer as a shareholder of the Company. The funds we are receiving from the overall transaction, totaling $46 Million,
will yield a strong pro forma cash balance for the Company of approximately $80 Million as of September 30, 2015 enabling us to
aggressively push our clinical pipeline forward and concentrate on our new strategy of developing clinically superior biologics&rdquo;
said Moshe Manor, Protalix&rsquo;s President and Chief Executive Officer. &ldquo;Additionally, we are very happy to restructure
and extend our existing relationship with Pfizer as they have shown their commitment to Gaucher patients and treating physicians.&rdquo;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">Pursuant to the amended collaboration
agreement, the Company will receive $36 Million in cash from Pfizer for the Company&rsquo;s share in the collaboration agreement
and the Israeli territory, while Pfizer will transfer to the Company full commercialization rights in Brazil thereby eliminating
annual payments of up to $12.5 Million to which Pfizer was entitled.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">In addition to the $36 Million cash
payment, pursuant to a stock purchase agreement, Pfizer agreed to make a $10 Million investment in exchange for 5,649,079 shares
of the Company&rsquo;s common stock subject to certain other terms referenced under the stock purchase agreement.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&ldquo;We look forward to expanding
the availability of ELELYSO and our successful patient support programs to the Gaucher patient community globally,&rdquo; said
Michael Goettler, Global Commercial Officer, Global Innovative Pharma Business, Pfizer Inc. &ldquo;This amended agreement underscores
Pfizer&rsquo;s long-standing commitment to serving the needs of patients living with rare diseases.&rdquo;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black"><B>About
Protalix</B>&nbsp;<B>BioTherapeutics, Inc.</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black">Protalix
is a biopharmaceutical company focused on the development and commercialization of recombinant therapeutic proteins expressed
through its proprietary plant cell-based expression system, ProCellEx<SUP>&reg;</SUP>.&nbsp;Protalix&rsquo;s unique expression
system presents a proprietary method for developing recombinant proteins in a cost-effective, industrial-scale manner.&nbsp;Protalix&rsquo;s
first product manufactured by ProCellEx, taliglucerase alfa, was approved for marketing by the&nbsp;U.S. Food and Drug Administration
(FDA) in&nbsp;May 2012, by&nbsp;Israel&rsquo;s&nbsp;Ministry of Health&nbsp;in&nbsp;September 2012, by the&nbsp;Brazilian National
Health Surveillance Agency&nbsp;(ANVISA) in&nbsp;March 2013,&nbsp;and by the regulatory authorities of other countries.&nbsp;
Protalix&rsquo;s development pipeline includes the following product candidates: PRX-102, a modified version of the recombinant
human alpha-GAL-A protein for the treatment of Fabry disease; PRX-112, an orally-delivered glucocerebrosidase enzyme that is produced
and encapsulated within carrot cells, for the treatment of Gaucher disease; PRX-106, an orally-delivered anti-inflammatory<FONT STYLE="font-size: 10pt">
</FONT>treatment; PRX-110 for the treatment of Cystic Fibrosis; and others.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black"><B>Forward-Looking
Statements</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black">To the
extent that statements in this press release are not strictly historical, all such statements are forward-looking, and are made
pursuant to the safe-harbor provisions of the Private Securities Litigation Reform Act of 1995.&nbsp;The terms &ldquo;anticipate,&rdquo;
&ldquo;believe,&rdquo; &ldquo;estimate,&rdquo; &ldquo;expect,&rdquo; &ldquo;plan&rdquo; and &ldquo;intend&rdquo; and other words
or phrases of similar import are intended to identify forward-looking statements.&nbsp;These forward-looking statements are subject
to known and unknown risks and uncertainties that may cause actual future experience and results to differ materially from the
statements made.&nbsp;These statements are based on our current beliefs and expectations as to such future outcomes.&nbsp;Drug
discovery and development involve a high degree of risk.&nbsp;Factors that might cause material differences include, among others:
risks relating to the non-compliance by Funda&ccedil;&atilde;o Oswaldo Cruz with its purchase obligations and related milestones
under our supply and technology transfer agreement for Brazil; risks related to the commercialization efforts for taliglucerase
alfa in Brazil; failure or delay in the commencement or completion of our preclinical and clinical trials which may be caused
by several factors, including: lack of sufficient funding to finance clinical trials; unforeseen safety issues; determination
of dosing issues; lack of effectiveness during clinical trials; slower than expected rates of patient recruitment; inability to
monitor patients adequately during or after treatment; and the inability or unwillingness of medical investigators and institutional
review boards to follow our clinical protocols; the risk that the results of the clinical trials of our product candidates will
not support our claims of safety or efficacy, that our product candidates will not have the desired effects or will be associated
with undesirable side effects or other unexpected characteristics; our dependence on performance by third party providers of services
and supplies, including without limitation, clinical trial services; delays in our preparation and filing of applications for
regulatory approval; delays in the approval or potential rejection of any applications we file with the&nbsp;FDA&nbsp;or other
health regulatory authorities, and other risks relating to the review process; the inherent risks and uncertainties in developing
drug platforms and products of the type we are developing; the impact of development of competing therapies and/or technologies
by other companies and institutions; potential product liability risks, and risks of securing adequate levels of product liability
and other necessary insurance coverage; and other factors described in our filings with the&nbsp;U.S. Securities and Exchange
Commission.&nbsp;The statements in this release are valid only as of the date hereof and we disclaim any obligation to update
this information.</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black">CONTACT:
Investor Contact</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0.25in; text-indent: 0in; text-align: justify"><FONT STYLE="color: Black">Marcy
Nanus</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0.25in; text-indent: 0in; text-align: justify"><FONT STYLE="color: Black">The
Trout Group, LLC</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0.25in; text-indent: 0in; text-align: justify"><FONT STYLE="color: Black">646-378-2927</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 0.25in; text-indent: 0in; text-align: justify"><FONT STYLE="color: Black">mnanus@troutgroup.com</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">Source: Protalix BioTherapeutics,
Inc.</FONT></P>

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