<SEC-DOCUMENT>0000078003-18-000020.txt : 20180213
<SEC-HEADER>0000078003-18-000020.hdr.sgml : 20180213
<ACCEPTANCE-DATETIME>20180213172300
ACCESSION NUMBER:		0000078003-18-000020
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20180213
DATE AS OF CHANGE:		20180213
GROUP MEMBERS:		C. P. PHARMACEUTICALS INTERNATIONAL C.V.
GROUP MEMBERS:		PFIZER MANUFACTURING LLC
GROUP MEMBERS:		PFIZER PRODUCTION LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Protalix BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001006281
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				650643773
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-50118
		FILM NUMBER:		18604986

	BUSINESS ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			20100
		BUSINESS PHONE:		972-4-988-9488

	MAIL ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			20100

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORTHODONTIX INC
		DATE OF NAME CHANGE:	19980422

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EMBASSY ACQUISITION CORP
		DATE OF NAME CHANGE:	19960124

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PFIZER INC
		CENTRAL INDEX KEY:			0000078003
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				135315170
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		235 E 42ND ST
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		2125732323

	MAIL ADDRESS:	
		STREET 1:		235 E 42ND ST
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PFIZER CHARLES & CO INC
		DATE OF NAME CHANGE:	19710908
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>protalix13ga1.htm
<DESCRIPTION>SCHEDULE 13G AMENDMENT 1
<TEXT>
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<div><a name="s1453797A4EA5B7694292902CC0B89A6C"></a></div><div></div><div><br></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">&#160;</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:center;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">UNITED STATES <br>SECURITIES AND EXCHANGE COMMISSION <br>WASHINGTON, D.C. 20549</font><font style="font-family:inherit;font-size:12pt;">&#32;</font><font style="font-family:inherit;font-size:10pt;">&#32;<br> <br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">SCHEDULE 13G</font><font style="font-family:inherit;font-size:12pt;">&#32;</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934 <br>(Amendment No. 1)*</font><font style="font-family:inherit;font-size:10pt;">&#32;<br> <br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">Protalix BioTherapeutics, Inc.</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>(Name of Issuer)</font><font style="font-family:inherit;font-size:10pt;">&#32;<br> <br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">Common Stock, par value $0.001 per share </font><font style="font-family:inherit;font-size:12pt;">&#32;<br>(Title of Class of Securities)</font><font style="font-family:inherit;font-size:10pt;">&#32;<br> <br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">74365A101</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>(CUSIP Number)</font><font style="font-family:inherit;font-size:10pt;">&#32;<br> <br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">December 31, 2017</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>(Date of Event Which Requires Filing of this Statement)</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>Check the appropriate box to designate the rule pursuant to which this Schedule <br>is filed:</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>|_| Rule 13d-1(b) <br>|X| Rule 13d-1(c) <br>|_| Rule 13d-1(d)</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">CUSIP No.&#160;&#160;74365A101 <br>-------------------------------------------------------------------------------- <br>1) Names of Reporting Persons. PFIZER INC. <br>I.R.S. Identification Nos. of Above Persons (entities only) 13-5315170 <br>-------------------------------------------------------------------------------- <br>2) Check the Appropriate Box if a Member of a Group (See Instructions)</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">(a) |_| <br>(b) |X| <br></font></div><div><br></div><div></div><hr style="page-break-after:always"><div></div><div><br></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">-------------------------------------------------------------------------------- <br>3) SEC Use Only <br>-------------------------------------------------------------------------------- <br>4) Citizenship or Place of Organization <br>Delaware <br>--------------------------------------------------------------------------------</font></div><div style="line-height:120%;font-size:12pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:88.67521367521367%;border-collapse:collapse;text-align:left;"><tr><td colspan="2"></td></tr><tr><td style="width:27%;"></td><td style="width:73%;"></td></tr><tr><td rowspan="4" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">NUMBER OF <br>SHARES  <br>BENEFICIALLY  <br>OWNED BY EACH REPORTING <br>PERSON WITH:</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">5. Sole Voting Power &#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">6. Shared Voting Power &#160;5,649,079 shares of Common Stock, $0.001 par value per share ("Common Stock")</font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">7. Sole Dispositive Power&#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">8. Shared Dispositive Power 5,649,079 shares of Common Stock </font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr></table></div></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">-------------------------------------------------------------------------------- <br>9) Aggregate Amount Beneficially Owned by Each Reporting Person 5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares <br>(See Instructions) |_| <br>11) Percent of Class Represented by Amount in Item 9 &#160;3.92%</font><font style="font-family:inherit;font-size:10pt;">(2)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>12) Type of Reporting Person (See Instructions)&#160;&#160; CO</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;"><br></font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">CUSIP No.&#160;&#160;74365A101 <br>-------------------------------------------------------------------------------- <br>1) Names of Reporting Persons. C. P. Pharmaceuticals International C.V. &#160; <br>I.R.S. Identification Nos. of Above Persons (entities only) 98-0182045 <br>-------------------------------------------------------------------------------- <br>2) Check the Appropriate Box if a Member of a Group (See Instructions) <br>(a) |_| <br>(b) |X| <br>-------------------------------------------------------------------------------- <br>3) SEC Use Only <br>-------------------------------------------------------------------------------- <br>4) Citizenship or Place of Organization <br>Netherlands <br>--------------------------------------------------------------------------------</font></div><div style="line-height:120%;font-size:12pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:88.67521367521367%;border-collapse:collapse;text-align:left;"><tr><td colspan="2"></td></tr><tr><td style="width:27%;"></td><td style="width:73%;"></td></tr><tr><td rowspan="4" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">NUMBER OF <br>SHARES  <br>BENEFICIALLY  <br>OWNED BY EACH REPORTING <br>PERSON WITH:</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">5. Sole Voting Power &#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">6. Shared Voting Power &#160;5,649,079 shares of Common Stock, $0.001 par value per share ("Common Stock")</font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">7. Sole Dispositive Power&#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">8. Shared Dispositive Power 5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr></table></div></div><div><br></div><div></div><hr style="page-break-after:always"><div></div><div><br></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">-------------------------------------------------------------------------------- <br>9) Aggregate Amount Beneficially Owned by Each Reporting Person 5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares <br>(See Instructions) |_| <br>11) Percent of Class Represented by Amount in Item 9 &#160;3.92%</font><font style="font-family:inherit;font-size:10pt;">(2)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>12) Type of Reporting Person (See Instructions)&#160;&#160;PN <br>&#160;</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">CUSIP No.&#160;&#160;74365A101 <br>-------------------------------------------------------------------------------- <br>1) Names of Reporting Persons. PFIZER PRODUCTION LLC <br>I.R.S. Identification Nos. of Above Persons (entities only) 52-2090275 <br>-------------------------------------------------------------------------------- <br>2) Check the Appropriate Box if a Member of a Group (See Instructions) <br>(a) |_| <br>(b) |X| <br>-------------------------------------------------------------------------------- <br>3) SEC Use Only <br>-------------------------------------------------------------------------------- <br>4) Citizenship or Place of Organization <br>Delaware <br>--------------------------------------------------------------------------------</font></div><div style="line-height:120%;font-size:12pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:88.67521367521367%;border-collapse:collapse;text-align:left;"><tr><td colspan="2"></td></tr><tr><td style="width:27%;"></td><td style="width:73%;"></td></tr><tr><td rowspan="4" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">NUMBER OF <br>SHARES  <br>BENEFICIALLY  <br>OWNED BY EACH REPORTING <br>PERSON WITH:</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">5. Sole Voting Power &#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">6. Shared Voting Power &#160;5,649,079 shares of Common Stock, $0.001 par value per share ("Common Stock")</font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">7. Sole Dispositive Power&#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">8. Shared Dispositive Power 5,649,079 shares of Common Stock </font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr></table></div></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">-------------------------------------------------------------------------------- <br>9) Aggregate Amount Beneficially Owned by Each Reporting Person 5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares <br>(See Instructions) |_| <br>11) Percent of Class Represented by Amount in Item 9 &#160;3.92%</font><font style="font-family:inherit;font-size:10pt;">(2)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>12) Type of Reporting Person (See Instructions)&#160;&#160; OO</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">CUSIP No.&#160;&#160;74365A101 <br>-------------------------------------------------------------------------------- <br>1) Names of Reporting Persons. PFIZER MANUFACTURING LLC</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">I.R.S. Identification Nos. of Above Persons (entities only)&#160; 52-2090292 <br>-------------------------------------------------------------------------------- <br>2) Check the Appropriate Box if a Member of a Group (See Instructions) <br>(a) |_| <br></font></div><div><br></div><div></div><hr style="page-break-after:always"><div></div><div><br></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">(b) |X| <br>-------------------------------------------------------------------------------- <br>3) SEC Use Only <br>-------------------------------------------------------------------------------- <br>4) Citizenship or Place of Organization <br>Delaware <br>--------------------------------------------------------------------------------</font></div><div style="line-height:120%;font-size:12pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:88.67521367521367%;border-collapse:collapse;text-align:left;"><tr><td colspan="2"></td></tr><tr><td style="width:27%;"></td><td style="width:73%;"></td></tr><tr><td rowspan="4" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">NUMBER OF <br>SHARES  <br>BENEFICIALLY  <br>OWNED BY EACH REPORTING <br>PERSON WITH:</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">5. Sole Voting Power &#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">6. Shared Voting Power &#160;5,649,079 shares of Common Stock, $0.001 par value per share ("Common Stock")</font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:6px;padding-bottom:6px;padding-right:2px;"><div style="padding-bottom:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">7. Sole Dispositive Power&#160;0</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:6px;padding-top:6px;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">8. Shared Dispositive Power 5,649,079 shares of Common Stock </font><font style="font-family:inherit;font-size:10pt;">(1)</font></div></td></tr></table></div></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">-------------------------------------------------------------------------------- <br>9) Aggregate Amount Beneficially Owned by Each Reporting Person 5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares <br>(See Instructions) |_| <br>11) Percent of Class Represented by Amount in Item 9 &#160;3.92%</font><font style="font-family:inherit;font-size:10pt;">(2)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>12) Type of Reporting Person (See Instructions)&#160;&#160; OO <br>&#160;</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">ITEM 1. <br>(A) NAME OF ISSUER: Protalix BioTherapeutics, Inc. <br>(B) ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICE: <br>2 Snunit Street, Science Park, POB 455, Carmiel, Israel 20100</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>ITEM 2. <br>(A) NAME OF PERSONS FILING: This statement is being filed by Pfizer Inc., a Delaware corporation ("Pfizer"), and Pfizer Production LLC, a Delaware limited liability company&#160; ("PPL") and &#160;Pfizer Manufacturing LLC, a Delaware limited liability company ("PML" and, together with PPL, the "General Partners"), acting in their capacity as general partners for and on behalf of&#160; C. P. Pharmaceuticals International C.V. , a Netherlands limited partnership (collectively, the "Shareholder"). The Shareholder and the General Partners are indirect wholly-owned subsidiaries of Pfizer.&#160;  <br>(B) ADDRESS OF PRINCIPAL BUSINESS OFFICE OR IF NONE, RESIDENCE: <br>&#160;The principal address of Pfizer, the Shareholder, PPL and PML is 235 E. 42nd Street, New York, NY 10017.  <br>(C) CITIZENSHIP: Pfizer, PPL and PML are Delaware and the Shareholder is the Netherlands  <br>(D) TITLE OF CLASS OF SECURITIES: COMMON STOCK</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">(E) CUSIP NUMBER: &#160;74365A101 </font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>ITEM 3. If this statement is filed pursuant to &#167;&#167; 240.13d-1(b) or 240.13d-2(b) or (c), check </font></div><div><br></div><div></div><hr style="page-break-after:always"><div></div><div><br></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">whether the person filing is a:&#160; Not applicable. <br>(a)&#160;</font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).  <br>(b) </font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).  <br>(c)&#160;</font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c). <br>(d)&#160;</font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). <br>(e) </font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;An investment adviser in accordance with &#167;240.13d-1(b)(1)(ii)(E). <br>(f )&#160;</font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#160;An employee benefit plan or endowment fund in accordance with &#167;240.13d-1(b)(1)(ii)(F).  <br>(g) </font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#160;A parent holding company or control person in accordance with &#167;240.13d-1(b)(1)(ii)(G).&#160;&#160; <br>(h)&#160;</font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813).  <br>(i )&#160;</font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3). &#160;&#160; <br>(j) &#160;</font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;A non-US institution, in accordance&#160;with &#167;240.13d-1(b)(1)(ii)(J);&#160; <br>(k) </font><font style="font-family:Wingdings;font-size:12pt;">&#168;</font><font style="font-family:inherit;font-size:12pt;">&#32;Group, in accordance with &#167;230.405 240.13d-1(b)(1)(ii)(K).</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>If filing as a non-US institution in accordance with &#167;240.13d-1(b)(1)(ii)(J), please specify the type of institution: Not applicable.</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">ITEM 4. OWNERSHIP. <br>(a) Amount beneficially owned: 5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font><font style="font-family:inherit;font-size:12pt;">&#32;&#32;<br>(b) Percent of class: 3.92%</font><font style="font-family:inherit;font-size:10pt;">(2)</font><font style="font-family:inherit;font-size:12pt;">&#32;<br>(c) Number of shares as to which the person has:  <br>(i) Sole power to vote or to direct the vote: &#160;0 <br>(ii) Shared power to vote or to direct the vote: 5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font><font style="font-family:inherit;font-size:12pt;">&#32;&#32;<br>(iii) Sole power to dispose or to direct the disposition of: &#160;0 <br>(iv) Shared power to dispose or to direct the disposition of:&#160;&#160;&#160;5,649,079 shares of Common Stock</font><font style="font-family:inherit;font-size:10pt;">(1)</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:10pt;">(1)</font><font style="font-family:inherit;font-size:12pt;">Amount consists of 5,649,079 shares of the Issuer's Common Stock held by the Shareholder. &#160;Pfizer may be deemed to have beneficial ownership over such shares since the Shareholder is an indirect wholly-owned subsidiary of Pfizer.&#160; The General Partners may be deemed to have beneficial ownership over such shares as the general partners of the Shareholder.&#160; </font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:10pt;">(2)</font><font style="font-family:inherit;font-size:12pt;">&#32;The ownership percentage of the Reporting Person set forth in Row 11 of the cover page hereto has been calculated based on an assumed total of 144,000,000 shares of Common Stock outstanding as of December 31, 2017, as reported in the Issuer&#8217;s Form 8-K filed with the Securities and Exchange Commission on January 5, 2018.</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS  | </font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">X</font><font style="font-family:inherit;font-size:12pt;">&#32;| <br>ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">Not applicable. <br>ITEM 7. &#160;IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY <br>Not applicable. <br></font></div><div><br></div><div></div><hr style="page-break-after:always"><div></div><div><br></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP <br>Not applicable. <br>ITEM 9. NOTICE OF DISSOLUTION OF GROUP <br>Not applicable. <br>ITEM 10. CERTIFICATION.</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &#167;240.14a-11.</font></div><div><br></div><div></div><hr style="page-break-after:always"><div></div><div><br></div><div style="line-height:138%;padding-bottom:13px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;"><br></font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:center;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">&#32;<br>&#160;</font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">Signature</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>Dated: February 13, 2018</font><font style="font-family:inherit;font-size:10pt;">&#32;<br> <br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">PFIZER INC.</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By: /s/Susan Grant <br>Name: Susan Grant <br>Title: Assistant Secretary</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">For and on behalf of C. P. PHARMACEUTICALS INTERNATIONAL C.V. , </font><font style="font-family:inherit;font-size:12pt;">by its General Partners </font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">Pfizer Production LLC  <br>as general partner for and on behalf of C. P. Pharmaceuticals International C.V. </font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By:  /s/ Colum Lane <br>Name:&#160; Colum Lane <br>Title: Senior Vice President </font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">Pfizer Manufacturing LLC <br>as general partner for and on behalf of C. P. Pharmaceuticals International C.V.&#160; </font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By:  /s/ Brian McMahon <br>Name: Brian McMahon <br>Title: Senior Vice President </font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">PFIZER PRODUCTION LLC</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By:  /s/ Darren Welsh <br>Name: Darren Welsh <br>Title: Secretary</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">PFIZER MANUFACTURING LLC</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By: /s/ Darren Welsh <br>Name: Darren Welsh <br>Title: Secretary</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">&#160;</font></div><div><br></div><div></div>	</body>
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<DESCRIPTION>EXHIBIT 99.1
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<div><a name="s3bf1cc460c344e898691db5322bc6088"></a></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div><div><br></div><hr style="page-break-after:always"><div><a name="sA8753364B9523B7DD24A903240211775"></a></div><div></div><div><br></div><div style="line-height:120%;text-align:right;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">Exhibit 99.1</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;"><br></font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:center;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">Joint Filing Agreement Pursuant to Rule 13d-1</font><font style="font-family:inherit;font-size:12pt;">&#32;</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">&#32;<br>This agreement is made pursuant to Rule 13d-l(k)(1) under the Securities and Exchange Act of 1934, as amended (the &#8220;Act&#8221;) by and among the parties listed below, each referenced to herein as a &#8220;Joint Filer.&#8221; The Joint Filers agree that a statement of beneficial ownership as required by Sections 13(g) or 13(d) of the Act and the Rules thereunder may be filed on each of their behalf on Schedule 13G or Schedule 13D, as appropriate, and that said joint filing may thereafter be amended by further joint filings. The Joint Filers state that they each satisfy the requirements for making a joint filing under Rule 13d-1.</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">&#32;<br>Dated: February 13, 2018</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">PFIZER INC.</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By: /s/ Susan Grant <br>Name: Susan Grant <br>Title: Assistant Secretary</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;font-weight:bold;">For and on behalf of&#160; C. P. PHARMACEUTICALS INTERNATIONAL C.V., </font><font style="font-family:inherit;font-size:12pt;">by its General Partners  <br>Pfizer Production LLC as general partner for and on behalf of C. P. Pharmaceuticals International C.V. </font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">By:  /s/ Colum Lane <br>Name: Colum Lane <br>Title: Senior Vice President </font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>Pfizer Manufacturing LLC  <br>as general partner for and on behalf of C. P. Pharmaceuticals International C.V. </font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">&#32;<br>By: /s/ Brian McMahon <br>Name: Brian McMahon <br>Title: Senior Vice President </font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;"><br></font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">PFIZER PRODUCTION LLC</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By: /s/Darren Welsh <br>Name: Darren Welsh <br>Title: Secretary</font></div><div><br></div><div></div><hr style="page-break-after:always"><div></div><div><br></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;font-weight:bold;">PFIZER MANUFACTURING LLC</font><font style="font-family:inherit;font-size:10pt;">&#32;<br></font><font style="font-family:inherit;font-size:12pt;">&#32;<br>By: /s/Darren Welsh <br>Name: Darren Welsh <br>Title: Secretary</font></div><div style="line-height:120%;padding-bottom:6px;padding-top:6px;text-align:left;font-size:12pt;"><font style="font-family:inherit;font-size:12pt;">&#160;</font></div><div style="line-height:138%;padding-bottom:13px;text-align:left;font-size:11pt;"><font style="font-family:inherit;font-size:11pt;"><br></font></div><div><br></div><div></div>	</body>
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