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SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jul. 23, 2018 | Oct. 19, 2017 | Oct. 31, 2015 | Sep. 30, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Jan. 01, 2019 | Dec. 31, 2016
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share |  |  |  |  | $ 0.001 | $ 0.001 |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  |  |  | 7,838,120 | 7,458,380 | 7,684,820 |  |
Retained Earnings (Accumulated Deficit) |  |  |  |  | $ (340,829) | $ (322,553) |  |  |
Cash and Cash Equivalents, at Carrying Value |  |  |  |  | $ 17,792 | 37,808 | $ 51,163 |  | $ 63,281
Tax Rate Assumption Related To Deferred Tax Difference Reversal |  |  |  |  | The Company used statutory tax rates of 27% and 23%. |  |  |  |
Incremental average borrowing rate at inception |  |  |  |  | 12.58% |  |  |  |
Operating Lease, Right-of-Use Asset |  |  |  |  | $ 5,677 | $ 0 |  | $ 5,900 |
Operating Lease, Liability |  |  |  |  | 5,667 |  |  | $ 5,700 |
2021 Notes [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Long-term Debt, Gross |  |  |  |  | $ 57,900 |  |  |  |
Amended Pfizer Agreement [Member] | Protalix Bio Therapeutics Incorporation [Member] | Brazil [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Collaborative Arrangement Revenues and Expenses Sharing Percentage |  |  | 100.00% |  |  |  |  |  |
Chiesi US Agreement [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Upfront Nonrefundable Non-Creditable Payment Receivable | $ 25,000 | $ 25,000 |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs | 20,000 |  |  |  |  |  |  |  |
Maximum Entitlement Of Development Costs To Cover Per Year | 7,500 |  |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones | $ 760,000 |  |  |  |  |  |  |  |
Contract with Customer, Asset, Cumulative Catch-up Adjustment to Revenue, Modification of Contract |  |  |  | $ 6,200 |  |  |  |  |
Chiesi US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage | 15.00% |  |  |  |  |  |  |  |
Chiesi US Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage | 40.00% |  |  |  |  |  |  |  |
Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Upfront Nonrefundable Non-Creditable Payment Receivable |  | 25,000 |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  | 25,000 |  |  |  |  |  |  |
Maximum Entitlement Of Development Costs To Cover Per Year |  | 10,000 |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  | $ 320,000 |  |  |  |  |  |  |
Chiesi Ex US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  | 15.00% |  |  |  |  |  |  |
Chiesi Ex US Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  | 35.00% |  |  |  |  |  |  |

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