<SEC-DOCUMENT>0001178913-20-003242.txt : 20201124
<SEC-HEADER>0001178913-20-003242.hdr.sgml : 20201124
<ACCEPTANCE-DATETIME>20201124060441
ACCESSION NUMBER:		0001178913-20-003242
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20201124
DATE AS OF CHANGE:		20201124

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Protalix BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001006281
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				650643773
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-50118
		FILM NUMBER:		201339808

	BUSINESS ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			2161401
		BUSINESS PHONE:		972-4-988-9488

	MAIL ADDRESS:	
		STREET 1:		2 SNUNIT ST
		STREET 2:		SCIENCE PARK, POB 455
		CITY:			CARMIEL
		STATE:			L3
		ZIP:			2161401

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ORTHODONTIX INC
		DATE OF NAME CHANGE:	19980422

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EMBASSY ACQUISITION CORP
		DATE OF NAME CHANGE:	19960124

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NACHT MARIUS
		CENTRAL INDEX KEY:			0001218503

	FILING VALUES:
		FORM TYPE:		SC 13G

	MAIL ADDRESS:	
		STREET 1:		18 YEHEZKEL ST
		CITY:			TEL AVIV-YAFO
		STATE:			L3
		ZIP:			6259524
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
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<DESCRIPTION>SC 13G
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNITED STATES<br>
        <font style="font-size: 14pt;">SECURITIES AND EXCHANGE COMMISSION</font><br>
        Washington, D.C. 20549</div>
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      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SCHEDULE 13G</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
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      <div style="line-height: 1.25;">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
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      <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(b)</div>
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      <div style="text-indent: 28.35pt; line-height: 1.25;">&#9746;&#160; Rule 13d-1(c)</div>
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      <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(d)</div>
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      <div style="line-height: 1.25;">The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
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                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">NAMES OF REPORTING PERSONS</div>
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              <td style="BORDER-TOP: #000000 1pt solid; VERTICAL-ALIGN: middle; WIDTH: 2.05%">
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              <td style="BORDER-TOP: #000000 1pt solid; BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
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                  <div style="line-height: 1.25;">Angels Investments in Hi Tech Ltd</div>
                  <div style="line-height: 1.25;"> <br>
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                  <div style="line-height: 1.25;">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY).</div>
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                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
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              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
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                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">3</div>
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                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SEC USE ONLY</div>
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                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%; BACKGROUND-COLOR: #bfbfbf">
                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
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                <div style="TEXT-ALIGN: left">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
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              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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                <div>Israel<br>
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              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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                <div style="TEXT-ALIGN: center">NUMBER OF</div>
                <div style="TEXT-ALIGN: center">SHARES </div>
                <div style="TEXT-ALIGN: center">BENEFICIALLY</div>
                <div style="TEXT-ALIGN: center"> OWNED BY </div>
                <div style="TEXT-ALIGN: center">EACH <br>
                </div>
                <div style="TEXT-ALIGN: center">REPORTING </div>
                <div style="TEXT-ALIGN: center">PERSON </div>
                <div style="TEXT-ALIGN: center">WITH</div>
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                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">5</div>
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              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 80.18%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOLE VOTING POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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                <div> 3,288,091 common shares </div>
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              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">6</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 80.18%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SHARED VOTING POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 80.18%">
                <div style="TEXT-ALIGN: left"> <br>
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                <div style="TEXT-ALIGN: left">0 <br>
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              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">7</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 80.18%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOLE DISPOSITIVE POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 80.18%">
                <div> <br>
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                <div> 3,288,091 common shares </div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
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            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">8</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 80.18%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SHARED DISPOSITIVE POWER</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
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              <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 80.18%">
                <div>
                  <div style="TEXT-ALIGN: left"> <br>
                  </div>
                  <div style="TEXT-ALIGN: left">0 <br>
                  </div>
                </div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
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              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">9</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="TEXT-ALIGN: left">
                  <div><br>
                  </div>
                  3,288,091 common shares</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">10</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK IF THE AGGREGATE AMOUNT IN ROW (9)&#160;EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="FONT-FAMILY: 'Times New Roman'; TEXT-ALIGN: left">&#9744;</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">11</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div> <br>
                </div>
                <div> 9.9%<br>
                </div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">12</div>
              </td>
              <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 89.86%">
                <div style="TEXT-ALIGN: left"> <br>
                </div>
                <div style="TEXT-ALIGN: left">CO <br>
                </div>
              </td>
              <td style="VERTICAL-ALIGN: middle; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.05%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
              <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 1.74%">
                <div style="TEXT-ALIGN: left">&#160;</div>
              </td>
            </tr>

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      <div id="DSPFPageHeader">
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          <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">Page 2 of 5 Pages</font></div>
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        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
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        <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="z15dc445435ec4935ab6990cf97d03876" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">

            <tr style="vertical-align: top;">
              <td style="vertical-align: top; width: 63pt;">
                <div style="line-height: 1.25;"><font style="font-weight: bold;">Item </font><font style="font-weight: bold;">1(a)</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="line-height: 1.25;"><font style="font-weight: bold;">Name of Issuer</font></div>
                <div style="line-height: 1.25;"><font style="font-weight: bold;"> <br>
                  </font></div>
                <div style="line-height: 1.25;">Protalix Bio Therapeutics Inc. (the "Issuer"). <font style="font-weight: bold;"> </font></div>
              </td>
            </tr>

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      <div style="line-height: 1.25;"> <br>
      </div>
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                <td style="vertical-align: top; width: 63pt;">
                  <div style="line-height: 1.25;"><font style="font-weight: bold;">Item </font><font style="font-weight: bold;">1(b)</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="line-height: 1.25;"><font style="font-weight: bold;">Address of Issuer's Principal Executive Offices</font></div>
                  <div style="line-height: 1.25;"><font style="font-weight: bold;"> <br>
                    </font></div>
                  <div style="line-height: 1.25;">2 Snunit Street, Science Partk POB 455 Carmiel 2161401, Israel</div>
                </td>
              </tr>

          </table>
        </div>
        <div style="line-height: 1.25;">&#160;</div>
      </div>
      <div style="line-height: 1.25;"><font style="font-weight: bold;">Item 2(a)-(b)</font>&#160;&#160;&#160; <font style="font-weight: bold;">Name of Person Filing; Address of Principal Business Office or, if none, Residence</font></div>
      <div style="line-height: 1.25">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="za0bc3bacb9ef43e9bb022a6ba5f62c0a" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 62pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top; align: right;">(a)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Angels Investments in Hi Tech Ltd. (&#8220;Angels&#8221;)</div>
              <div>
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">C/O Marius Nacht</div>
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8220;Reporting Person&#8221;</div>
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">From 42 Brandeis St. Tel Aviv 6200157, Israel</div>
              </div>
            </td>
          </tr>

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      <div style="margin-left: 108pt; line-height: 1.25;"> <br>
      </div>
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              <td style="vertical-align: top; width: 63pt;">
                <div style="line-height: 1.25;"><font style="font-weight: bold;">Item 2(c)</font></div>
              </td>
              <td style="align: left; vertical-align: top; width: auto;">
                <div style="line-height: 1.25;"><font style="font-weight: bold;">Citizenship</font></div>
                <div style="line-height: 1.25;"><font style="font-weight: bold;"> <br>
                  </font></div>
                <div style="line-height: 1.25;">Angels is incorporated under the laws of Israel. Marius Nacht who is sole shareholder and director of Angels is an Israeli citizen.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
      </div>
      <div style="line-height: 1.25">
        <div style="line-height: 1.25;">
          <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">

              <tr style="vertical-align: top;">
                <td style="vertical-align: top; width: 63pt;">
                  <div style="line-height: 1.25;"><font style="font-weight: bold;">Item 2(d)</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="line-height: 1.25;"><font style="font-weight: bold;">Title of Class of Securities</font></div>
                  <div style="line-height: 1.25;"><font style="font-weight: bold;"> <br>
                    </font></div>
                  Common Shares, par value NIS 0.001 per share</td>
              </tr>

          </table>
        </div>
        <div style="line-height: 1.25;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </div>
        <div style="line-height: 1.25;">
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              <tr style="vertical-align: top;">
                <td style="vertical-align: top; width: 63pt;">
                  <div style="line-height: 1.25;"><font style="font-weight: bold;">Item 2(e)</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="line-height: 1.25;"><font style="font-weight: bold;">CUSIP Number</font></div>
                  <div style="line-height: 1.25;"><font style="font-weight: bold;"> <br>
                    </font></div>
                  74365A309</td>
              </tr>

          </table>
        </div>
        <div style="line-height: 1.25;"> <br>
        </div>
      </div>
      <table cellspacing="0" cellpadding="0" id="zfed4fd93c9384efb9fa5dd57055e4037" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="vertical-align: top; width: 62pt; font-weight: bold;">Item 3</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">If this Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a:</div>
              <div style="font-weight: bold;"> <br>
              </div>
              <div style="font-weight: bold;"><font style="font-weight: normal;">Not applicable.</font> </div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="vertical-align: top; width: 62pt; font-weight: bold;">Item 4<br>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;"><font style="font-weight: bold;">Ownership</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div style="margin: 0px 0px 0px 62pt; line-height: 1.25;"></div>
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            <td style="width: 62pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">(a)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Amount beneficially owned</u>: 3,288,091(1)</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="zab70b7c3f8594c619db6a6001700bdeb" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 62pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">(b)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Percent of Class</u>: 9.9% (2)</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="zdad2c845d86847afaffe4f3f7b7fdcda" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 62pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">(c)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Number of shares as to which the person has</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z701a168f8eca4bbf8978d176b2723649" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 85pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top; align: right;">(i)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Sole power to vote or direct the vote: 3,288,091(1)</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" id="z06d115fbd9fe45538c58851e69f82346" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 85pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top; align: right;">(ii)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Shared power to vote or to direct the vote: 0</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" id="z120d4f4ad71f4ae7a2a9158e10ffa675" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 85pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top; align: right;">(iii)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Sole power to dispose or to direct the disposition of: 3,288,091(1)</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" id="zc8eda43d4f7547a9b25b360065c95a70" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 85pt;"><br>
            </td>
            <td style="width: 36pt; vertical-align: top; align: right;">(iv)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Shared power to dispose or to direct the disposition of :0</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <hr align="left" style="height: 2px; width: 20%; color: #000000; background-color: #000000; margin-left: 0px; margin-right: auto; border: none;"></div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <table cellspacing="0" cellpadding="0" id="z45401eadce694cb48b57476d5f377aa8" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">(1)</td>
            <td style="width: auto; vertical-align: top;">
              <div>The number of ordinary shares set forth above includes (i) 2,816,901 common shares of Protalix Bio Therapeutics, Inc (the &#8220;Issuer&#8221;), par value $0.001 per share (&#8220;Common Shares&#8221;) and (ii) 471,190 Common Shares issuable upon the exercise
                of currently exercisable warrants.</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" id="z12abaacc17c74e7c89832516947d3691" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top; align: right;">(2)</td>
            <td style="width: auto; vertical-align: top;">
              <div>All Share percentage calculation are based on (i) 32,442,636 Common Shares outstanding as of March 18, 2020, as reported by the Issuer to the reporting Persons and (ii) 471,190 Common Shares issuable upon the exercise of currently
                exercisable warrants, which are treated as issued and outstanding solely for the purpose of computing the percentage ownership of the Reporting Person pursuant to Rule 13d-3(d)(1)(i) under the Act.</div>
            </td>
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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">Page 3 of 5 Pages</font></div>
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              <td style="vertical-align: top; width: 62pt; font-weight: bold;">Item 5<br>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;"><font style="font-weight: bold;">Ownership of Five Percent or Less of a Class</font></div>
                <div style="font-weight: bold;"> <br>
                </div>
                <div style="font-weight: bold;">
                  <div style="margin-top: 0px; margin-bottom: 0px; line-height: 1.25;"><font style="font-weight: normal;">If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial
                      owner of more than 5 percent of the class of securities, check the following: &#9744;</font></div>
                </div>
              </td>
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        </table>
      </div>
      <br>
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            <td style="vertical-align: top; width: 62pt; font-weight: bold;">Item 6</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">Ownership of More than Five Percent on Behalf of Another Person</div>
              <div style="font-weight: bold;"> <br>
              </div>
              <div style="font-weight: bold;"><font style="font-weight: normal;">Not applicable.</font> </div>
            </td>
          </tr>

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      <div style="line-height: 1.25">&#160;</div>
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            <td style="width: 62pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 7</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company</div>
              <div style="font-weight: bold;"> <br>
              </div>
              <div style="font-weight: bold;"><font style="font-weight: normal;">Not applicable.</font> </div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25">&#160;</div>
      <div style="margin: 0px 0px 0px 62pt; line-height: 1.25;"></div>
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            <td style="width: 62pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 8</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">Identification and Classification of Members of the Group</div>
              <div style="font-weight: bold;"> <br>
              </div>
              <div style="font-weight: bold;"><font style="font-weight: normal;">Not applicable.</font> </div>
            </td>
          </tr>

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      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25;">
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              <td style="width: 62pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 9<br>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;"><font style="font-weight: bold;">Notice of Dissolution of Group</font></div>
                <div style="font-weight: bold;"> <br>
                </div>
                <div style="font-weight: bold;"><font style="font-weight: normal;">Not applicable.</font> </div>
              </td>
            </tr>

        </table>
      </div>
      <br>
      <div style="line-height: 1.25;">
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              <td style="width: 62pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Item 10<br>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-weight: bold;"><font style="font-weight: bold;">Certification</font></div>
                <div style="font-weight: bold;"> <br>
                </div>
                <div style="font-weight: normal;">
                  <div style="margin-top: 0px; margin-bottom: 0px; line-height: 1.25;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with
                    the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.</div>
                </div>
              </td>
            </tr>

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      <br>
      <div style="line-height: 1.25">&#160;</div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">Page 4 of 5 Pages</font></div>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signature</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
      <div style="line-height: 1.25">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zefd2d99e55a5433a9e74026d1740ca33" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="line-height: 1.25;">Dated: November 23, 2020</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;"> <br>
                </font></div>
              <div style="text-indent: -21.6pt; margin-left: 21.6pt; line-height: 1.25;">ANGELS INVESTMENTS IN HI TECH LTD.</div>
              <div style="text-indent: -21.55pt; margin-left: 21.55pt; line-height: 1.25;"> <br>
              </div>
              <div style="text-indent: -21.55pt; margin-left: 21.55pt; line-height: 1.25;">By:&#160;&#160; <u>/s/ Marius Nacht</u></div>
              <div style="text-indent: 0pt; margin-left: 21.6pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">MARIUS NACHT</div>
              <div style="text-indent: -21.6pt; margin-left: 21.6pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Sole Shareholder</div>
            </td>
          </tr>

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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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