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SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Details) - USD ($) |  |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | ---
Feb. 17, 2021 | Oct. 01, 2020 | Sep. 14, 2020 | Mar. 18, 2020 | Jul. 23, 2018 | Oct. 19, 2017 | Oct. 31, 2015 | Mar. 31, 2021 | Mar. 30, 2021 | Dec. 31, 2020 | Sep. 30, 2018 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) |  |  |  |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 | $ 0.001 |
Gross proceeds |  |  |  |  |  |  |  |  |  |  |  | $ 4,867,000 |  |
Exercise price of warrants (in dollars per share) |  |  |  |  |  |  |  |  |  | $ 2.36 |  | $ 2.36 |  |
Proceeds from private placement |  |  |  | $ 41,300,000 |  |  |  |  |  |  |  |  |  |
Notes Payable, Current |  |  |  |  |  |  |  |  |  | $ 4,086,000 |  | $ 4,086,000 | $ 4,301,000 |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  |  |  |  |  |  |  |  |  |  | 22,850,682 | 7,838,120 | 7,458,380
Rental expense |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,400,000
Operating Lease, Right-of-Use Asset |  |  |  |  |  |  |  |  |  | 5,567,000 |  | $ 5,567,000 | $ 5,677,000 |
Operating Lease, Liability |  |  |  |  |  |  |  |  |  | $ 5,887,000 |  | $ 5,887,000 | $ 5,700,000 |
Incremental average borrowing rate at inception |  |  |  |  |  |  |  |  |  |  |  | 12.58% |  |
Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share | 4.60 |  |  |  |  |  |  |  |  |  |  |  |  |
Share price | $ 4.60 |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds | $ 40,200,000 |  |  |  |  |  |  |  | $ 8,800,000 |  |  |  |  |
Number of shares issued (in shares) | 8,749,999 |  |  |  |  |  |  |  | 1,867,552 |  |  |  |  |
Seven Point Five Percentage Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate (as a percent) |  |  |  |  |  |  |  |  |  | 7.50% |  | 7.50% |  |
Notes Payable, Current |  |  |  |  |  |  |  |  |  | $ 57,900,000 |  | $ 57,900,000 |  |
2018 Notes [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Notes Payable, Current |  |  |  |  |  |  |  |  |  | $ 0 |  | $ 0 |  |
Term of debt |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years
Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Tax Rate Assumption Related To Deferred Tax Difference Reversal |  |  |  |  |  |  |  |  |  | 23.00% |  | 23.00% |  |
Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Tax Rate Assumption Related To Deferred Tax Difference Reversal |  |  |  |  |  |  |  |  |  | 26.00% |  | 26.00% |  |
Amended Pfizer Agreement [Member] | Protalix Bio Therapeutics Incorporation [Member] | Brazil [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement Revenues Expenses Sharing Percentage |  |  |  |  |  |  | 100.00% |  |  |  |  |  |  |
Chiesi US Agreement and Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Nonrefundable Non-Creditable Payment Receivable |  |  |  |  |  | $ 25,000,000.0 |  |  |  | $ 50,000,000.0 |  | $ 50,000,000.0 |  |
Chiesi US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Nonrefundable Non-Creditable Payment Receivable |  |  |  |  | $ 25,000,000.0 | 25,000,000.0 |  |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  | 20,000,000.0 |  |  |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  | $ 760,000,000.0 |  |  |  |  | 760,000,000.0 |  | $ 760,000,000.0 |  |
Contract with Customer, Asset, Cumulative Catch-up Adjustment to Revenue, Modification of Contract |  |  |  |  |  |  |  |  |  |  | $ 6,200,000 |  |  |
Chiesi US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  | 15.00% |  |  |  |  |  |  | 15.00% |  |
Chiesi US Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  | 40.00% |  |  |  |  |  |  | 40.00% |  |
Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Nonrefundable Non-Creditable Payment Receivable |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  |  | $ 320,000,000.0 |  |  |  | 320,000,000.0 |  | $ 320,000,000.0 |  |
Chiesi Ex US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 15.00% |  |  |  |  |  | 15.00% |  |
Chiesi Ex US Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 35.00% |  |  |  |  |  | 35.00% |  |
ATM Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds |  |  |  |  |  |  |  |  |  | $ 5,000,000 |  | $ 5,000,000.0 |  |
Sale Of Stock Maximum Offering Price |  | $ 30,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) |  |  |  |  |  |  |  |  |  | 1,428,571 |  | 1,428,571 |  |
ATM Shares | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds |  |  |  |  |  |  |  | $ 8,800,000 |  |  |  |  |  |
Number of shares issued (in shares) |  |  |  |  |  |  |  | 1,867,552 |  |  |  |  |  |
Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share price |  |  |  | $ 2.485 |  |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) |  |  | 200,000 | 17,604,423 |  |  |  |  |  |  |  |  |  |
Purchase price (in dollars per share) |  |  |  | $ 2.485 |  |  |  |  |  |  |  |  |  |
Number of warrants issued (in shares) |  |  |  | 17,604,423 |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) |  |  |  | $ 2.36 |  |  |  |  |  |  |  |  |  |
Exercise of warrants, commencement period |  |  |  | 6 months |  |  |  |  |  |  |  |  |  |
Term of warrants |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |
Proceeds from private placement |  |  |  | $ 43,700,000 |  |  |  |  |  |  |  |  |  |

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