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CONSOLIDATED STATEMENTS OF CHANGES IN CAPITAL DEFICIENCY - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Beginning balance | $ (70,322) | $ (52,881) | $ (29,457)
Issuance of common stock and warrants, net of issuance cost | 41,343 |  |
Issuance of common stock under the Sales Agreement, net | 4,867 |  |
Share-based compensation related to stock options | 2,264 | 835 | 498
Share-based compensation related to restricted stock award | 862 |  | 16
Convertible note conversions |  |  | 1,369
Convertible note payment |  |  | 1,150
Exercise of warrants | 472 |  |
Net loss | (6,523) | (18,276) | (26,457)
Ending balance | (27,037) | (70,322) | (52,881)
Common Stock [Member] |  |  |
Beginning balance | $ 15 | $ 15 | $ 14
Beginning balance (in shares) | 14,838,213 | 14,838,213 | 14,372,880
Issuance of common stock and warrants, net of issuance cost | $ 18 |  |
Issuance of common stock and warrants, net of issuance cost (in shares) | 17,604,423 |  |
Issuance of common stock under the Sales Agreement, net | $ 1 |  |
Issuance of common stock under the Sales Agreement, net (in shares) | 1,428,571 |  |
Share-based compensation related to restricted stock award | $ 1 |  |
Share-based compensation related to restricted stock award (in shares) | 694,073 |  | 2,990
Convertible note conversions (in shares) |  |  | 200,997
Convertible note payment |  |  | $ 1
Convertible note payment (in shares) |  |  | 261,346
Exercise of warrants (in shares) | 200,000 |  |
Ending balance | $ 35 | $ 15 | $ 15
Ending balance (in shares) | 34,765,280 | 14,838,213 | 14,838,213
Additional Paid-in Capital [Member] |  |  |
Beginning balance | $ 270,492 | $ 269,657 | $ 266,625
Issuance of common stock and warrants, net of issuance cost | 41,325 |  |
Issuance of common stock under the Sales Agreement, net | 4,866 |  |
Share-based compensation related to stock options | 2,264 | 835 | 498
Share-based compensation related to restricted stock award | 861 |  | 16
Convertible note conversions |  |  | 1,369
Convertible note payment |  |  | 1,149
Exercise of warrants | 472 |  |
Ending balance | 320,280 | 270,492 | 269,657
Accumulated Deficit [Member] |  |  |
Beginning balance | (340,829) | (322,553) | (296,096)
Net loss | (6,523) | (18,276) | (26,457)
Ending balance | $ (347,352) | $ (340,829) | $ (322,553)

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