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SIGNIFICANT ACCOUNTING POLICIES (Details) |  |  |  |  |  | 1 Months Ended | 3 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
May 14, 2021 USD ($) | Mar. 29, 2021 USD ($) | Feb. 17, 2021 USD ($) $ / shares shares | Feb. 10, 2021 USD ($) | Oct. 01, 2020 USD ($) | Sep. 30, 2020 USD ($) | Oct. 31, 2015 | Mar. 31, 2021 USD ($) agreement $ / shares shares | Mar. 31, 2020 $ / shares shares | Dec. 31, 2020 USD ($) | Jul. 23, 2018 USD ($) | Oct. 19, 2017 USD ($)
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) | shares |  |  | 8,749,999 |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  |  | $ 0.001 |  |  |  |  | $ 0.001 | $ 0.001 |  |  |
Gross proceeds |  |  | $ 40,200,000 |  |  |  |  | $ 8,575,000 |  |  |  |
Additional capital that the company can raise |  |  |  |  |  |  |  | 37,625,000 |  |  |  |
Shares Issued, Price Per Share | $ / shares |  |  | $ 4.60 |  |  |  |  |  |  |  |  |
Payment for promissory note |  |  |  |  |  |  |  | 4,086,000 |  |  |  |
Convertible Debt, Current |  |  |  |  |  |  |  | $ 55,372,000 |  | $ 54,427,000 |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares |  |  |  |  |  |  |  | 26,769,693 | 10,694,517 |  |  |
ATM Shares |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds |  |  |  |  |  |  |  | $ 8,800,000 |  |  |  |
Issuance of common stock under the Sales Agreement, net (in shares) | shares |  |  |  |  |  |  |  | 1,867,552 |  |  |  |
Sale of stock, maximum offering price |  |  |  |  | $ 30,000,000.0 |  |  |  |  |  |  |
ATM Shares | Scenario, Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Additional capital that the company can raise |  |  |  |  |  |  |  | $ 16,200,000 |  |  |  |
Seven Point Five Percentage Convertible Notes [Member] | Convertible Notes Payable [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Interest rate (as a percent) |  |  |  |  |  |  |  | 7.50% |  |  |  |
Debt Instrument, Face Amount |  |  |  |  |  |  |  | $ 57,900,000 |  |  |  |
Amended Pfizer Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment for promissory note |  | $ 4,000,000.0 |  |  |  | $ 430,000 |  |  |  |  |  |
Amended Pfizer Agreement [Member] | Protalix Bio Therapeutics Incorporation [Member] | Brazil [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement Revenues and Expenses Sharing Percentage |  |  |  |  |  |  | 100.00% |  |  |  |  |
Chiesi Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Performance Obligation, Number | agreement |  |  |  |  |  |  |  | 2 |  |  |  |
Chiesi US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  |  |  |  |  |  |  | $ 20,000,000.0 |
Maximum Entitlement Of Development Costs To Cover Per Year |  |  |  |  |  |  |  |  |  |  | 7,500,000 |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  |  |  |  |  |  |  | 760,000,000.0 |
Chiesi US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  |  |  | 15.00% |  |  |  |
Chiesi US Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  |  |  | 40.00% |  |  |  |
Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  |  |  |  |  |  |  |  | $ 25,000,000.0
Maximum Entitlement Of Development Costs To Cover Per Year |  |  |  |  |  |  |  |  |  |  |  | 10,000,000.0
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  |  |  |  |  |  |  |  | 320,000,000.0
Chiesi Ex US Agreement [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Agreement Amendment Payment Receivable | $ 10,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Change In Amount Receivable For Achievement Of Regulatory And Commercial Milestones | $ (25,000,000.0) |  |  |  |  |  |  |  |  |  |  |
Chiesi Ex US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  |  |  | 15.00% |  |  |  |
Chiesi Ex US Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  |  |  | 35.00% |  |  |  |
SarcoMed USA, Inc. Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
License Agreement, Initial Cash Payment |  |  |  | $ 3,500,000 |  |  |  |  |  |  |  |
Term to sign supply agreement |  |  |  | 60 days |  |  |  |  |  |  |  |
Chiesi US Agreement and Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Upfront Nonrefundable Non-Creditable Payment Receivable |  |  |  |  |  |  |  |  |  |  | $ 25,000,000.0 | $ 25,000,000.0

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