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SIGNIFICANT ACCOUNTING POLICIES (Details) |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 25, 2021 USD ($) $ / shares shares | Jul. 02, 2021 USD ($) $ / shares shares | May 13, 2021 USD ($) | Feb. 17, 2021 USD ($) $ / shares shares | Jul. 23, 2018 USD ($) | Oct. 19, 2017 USD ($) | Oct. 31, 2015 | Sep. 30, 2021 USD ($) agreement $ / shares shares | Sep. 30, 2020 $ / shares shares | Sep. 30, 2021 USD ($) agreement $ / shares shares | Sep. 30, 2020 $ / shares shares | Dec. 31, 2020 USD ($)
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) | shares |  |  |  | 8,749,999 |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 | $ 0.001 | $ 0.001 |
Gross proceeds |  |  |  | $ 40,200,000 |  |  |  |  |  | $ 8,575,000 |  |
Shares Issued, Price Per Share | $ / shares |  |  |  | $ 4.60 |  |  |  |  |  |  |  |
Net payment for convertible notes |  |  |  |  |  |  |  |  |  | 25,990,000 |  |
Convertible Debt, Current |  |  |  |  |  |  |  | $ 3,239,000 |  | $ 3,239,000 |  | $ 54,427,000
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares |  |  |  |  |  |  |  | 27,962,842 | 26,905,842 | 26,847,081 | 21,405,733 |
Maintain of Minimum Cash Balance |  |  |  |  |  |  |  | $ 7,500,000 |  | $ 7,500,000 |  |
ATM Shares |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) | shares |  | 3,296,123 |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  | $ 0.001 |  |  |  |  |  |  |  |  |  |
Sale of stock, maximum offering price |  | $ 20,000,000.0 |  |  |  |  |  |  |  |  |  |
Gross proceeds |  | $ 13,800,000 |  |  |  |  |  |  |  |  |  |
2021 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Principal amount | $ 54,650,000 |  |  |  |  |  |  |  |  |  |  |
2024 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Interest rate (as a percent) | 7.50% |  |  |  |  |  |  | 7.50% |  | 7.50% |  |
Net payment for convertible notes | $ 25,900,000 |  |  |  |  |  |  |  |  |  |  |
Convertible notes exchange in cash, accrued and unpaid interest | $ 1,100,000 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument Convertible Conversion Share Number | shares | 563.2216 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument Convertible Base Value For Conversion Rate | $ 1,000 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument, Convertible, Conversion Price | $ / shares | $ 1.7755 |  |  |  |  |  |  |  |  |  |  |
Percentage of Premium to Closing Price of Stock | 32.50% |  |  |  |  |  |  |  |  |  |  |
Principal amount | $ 28,750,000 |  |  |  |  |  |  |  |  |  |  |
Amended Pfizer Agreement | Protalix Bio Therapeutics Incorporation [Member] | Brazil [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement Revenues and Expenses Sharing Percentage |  |  |  |  |  |  | 100.00% |  |  |  |  |
Chiesi Agreements |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenue, Performance Obligation, Number | agreement |  |  |  |  |  |  |  | 2 |  | 2 |  |
Chiesi US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  | $ 20,000,000.0 |  |  |  |  |  |  |
Maximum Entitlement Of Development Costs To Cover Per Year |  |  |  |  | 7,500,000 |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  | $ 760,000,000.0 |  |  |  |  |  |  |
Chiesi US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  | 15.00% |  |  |  |  |  |  |
Chiesi US Agreement [Member] | Maximum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  | 40.00% |  |  |  |  |  |  |
Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  |  | $ 25,000,000.0 |  |  |  |  |  |
Maximum Entitlement Of Development Costs To Cover Per Year |  |  |  |  |  | 10,000,000.0 |  |  |  |  |  |
Agreement Amendment Payment Receivable |  |  | $ 10,000,000.0 |  |  |  |  |  |  |  |  |
Change In Amount Receivable For Achievement Of Regulatory And Commercial Milestones |  |  | $ 25,000,000.0 |  |  |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  |  | $ 320,000,000.0 |  |  |  |  |  |
Chiesi Ex US Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 15.00% |  |  |  |  |  |
Chiesi Ex US Agreement [Member] | Maximum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 35.00% |  |  |  |  |  |
Chiesi US Agreement and Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Upfront Nonrefundable Non-Creditable Payment Receivable |  |  |  |  | $ 25,000,000.0 | $ 25,000,000.0 |  |  |  |  |  |

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