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SIGNIFICANT ACCOUNTING POLICIES (Details)							1 Months Ended	3 Months Ended		9 Months Ended
SIGNIFICANT ACCOUNTING POLICIES (Details)	Aug. 25, 2021 USD ($) $ / shares shares	Jul. 02, 2021 USD ($) $ / shares shares	May 13, 2021 USD ($)	Feb. 17, 2021 USD ($) $ / shares shares	Jul. 23, 2018 USD ($)	Oct. 19, 2017 USD ($)	Oct. 31, 2015	Sep. 30, 2021 USD ($) agreement $ / shares shares	Sep. 30, 2020 $ / shares shares	Sep. 30, 2021 USD ($) agreement $ / shares shares	Sep. 30, 2020 $ / shares shares	Dec. 31, 2020 USD ($)
Significant Accounting Policies [Line Items]
Number of shares issued (in shares) \| shares				8,749,999
Common Stock, Par or Stated Value Per Share \| $ / shares								$ 0.001	$ 0.001	$ 0.001	$ 0.001
Gross proceeds				$ 40,200,000						$ 8,575,000
Shares Issued, Price Per Share \| $ / shares				$ 4.60
Net payment for convertible notes										25,990,000
Convertible Debt, Current								$ 3,239,000		$ 3,239,000		$ 54,427,000
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount \| shares								27,962,842	26,905,842	26,847,081	21,405,733
Maintain of Minimum Cash Balance								$ 7,500,000		$ 7,500,000
ATM Shares
Significant Accounting Policies [Line Items]
Number of shares issued (in shares) \| shares		3,296,123
Common Stock, Par or Stated Value Per Share \| $ / shares		$ 0.001
Sale of stock, maximum offering price		$ 20,000,000.0
Gross proceeds		$ 13,800,000
2021 Notes
Significant Accounting Policies [Line Items]
Principal amount	$ 54,650,000
2024 Notes
Significant Accounting Policies [Line Items]
Interest rate (as a percent)	7.50%							7.50%		7.50%
Net payment for convertible notes	$ 25,900,000
Convertible notes exchange in cash, accrued and unpaid interest	$ 1,100,000
Debt Instrument Convertible Conversion Share Number \| shares	563.2216
Debt Instrument Convertible Base Value For Conversion Rate	$ 1,000
Debt Instrument, Convertible, Conversion Price \| $ / shares	$ 1.7755
Percentage of Premium to Closing Price of Stock	32.50%
Principal amount	$ 28,750,000
Amended Pfizer Agreement \| Protalix Bio Therapeutics Incorporation [Member] \| Brazil [Member]
Significant Accounting Policies [Line Items]
Collaborative Arrangement Revenues and Expenses Sharing Percentage							100.00%
Chiesi Agreements
Significant Accounting Policies [Line Items]
Revenue, Performance Obligation, Number \| agreement								2		2
Chiesi US Agreement [Member]
Significant Accounting Policies [Line Items]
Additional Amounts Payable To Cover Development Costs					$ 20,000,000.0
Maximum Entitlement Of Development Costs To Cover Per Year					7,500,000
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones					$ 760,000,000.0
Chiesi US Agreement [Member] \| Minimum [Member]
Significant Accounting Policies [Line Items]
Payment On Net Sales Percentage					15.00%
Chiesi US Agreement [Member] \| Maximum
Significant Accounting Policies [Line Items]
Payment On Net Sales Percentage					40.00%
Chiesi Ex US Agreement [Member]
Significant Accounting Policies [Line Items]
Additional Amounts Payable To Cover Development Costs						$ 25,000,000.0
Maximum Entitlement Of Development Costs To Cover Per Year						10,000,000.0
Agreement Amendment Payment Receivable			$ 10,000,000.0
Change In Amount Receivable For Achievement Of Regulatory And Commercial Milestones			$ 25,000,000.0
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones						$ 320,000,000.0
Chiesi Ex US Agreement [Member] \| Minimum [Member]
Significant Accounting Policies [Line Items]
Payment On Net Sales Percentage						15.00%
Chiesi Ex US Agreement [Member] \| Maximum
Significant Accounting Policies [Line Items]
Payment On Net Sales Percentage						35.00%
Chiesi US Agreement and Chiesi Ex US Agreement [Member]
Significant Accounting Policies [Line Items]
Upfront Nonrefundable Non-Creditable Payment Receivable					$ 25,000,000.0	$ 25,000,000.0