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COMMERCIALIZATION AGREEMENTS (Details) - USD ($) |  |  |  | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
May 13, 2021 | Mar. 29, 2021 | Mar. 16, 2020 | Sep. 30, 2020 | Mar. 31, 2020 | Jul. 23, 2018 | Oct. 19, 2017 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Jun. 30, 2021 | Oct. 31, 2015 | Nov. 30, 2009
Promissory note |  |  |  |  |  |  |  |  | $ 4,086,000 |  |  |  |
Payment for promissory note |  |  |  |  |  |  |  | $ 4,086,000 | 215,000 |  |  |  |
Brazil [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage Of Adult Gaucher Patients Treated With alfataliglicerase |  |  |  |  |  |  |  | 25.00% |  |  |  |  |
Pfizer [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement Profit Share Percentage |  |  |  |  |  |  |  |  |  |  |  |  | 40.00%
Debt Instrument, Face Amount |  |  |  |  |  |  |  |  |  |  |  | $ 4,300,000 |
Promissory note |  |  |  | $ 4,300,000 |  |  |  |  |  |  |  |  |
Payment on notes payable |  |  |  | $ 430,000 |  |  |  |  |  |  |  |  |
Payment for promissory note |  | $ 4,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Chiesi US Agreement and Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable Payment Receivable |  |  |  |  |  |  | $ 25,000,000.0 | $ 50,000,000.0 |  |  |  |  |
Agreement Amendment Payment Receivable |  |  |  |  |  |  |  | 10,000,000.0 |  |  | $ 10,000,000.0 |  |
Payments in consideration for development services performed |  |  |  |  |  |  |  | 45,000,000.0 |  |  |  |  |
Payments in connection with performance of additional studies |  |  |  |  |  |  |  | 33,600,000 |  |  |  |  |
Recognized revenues related to non-refundable payment |  |  |  |  |  |  |  | 600,000 | 3,500,000 | $ 4,500,000 |  |  |
Future milestone payment |  |  |  |  |  |  |  |  | $ 10,000,000.0 | $ 10,000,000.0 |  |  |
Chiesi US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable Payment Receivable |  |  |  |  |  | $ 25,000,000.0 | 25,000,000.0 |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  |  | 20,000,000.0 |  |  |  |  |  |  |
Maximum Entitlement Of Development Costs To Cover Per Year |  |  |  |  |  | 7,500,000 |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  |  | $ 760,000,000.0 |  | $ 735,000,000.0 |  |  |  |  |
Chiesi US Agreement [Member] | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 40.00% |  | 40.00% |  |  |  |  |
Chiesi US Agreement [Member] | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 15.00% |  | 15.00% |  |  |  |  |
Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable Payment Receivable |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |
Maximum Entitlement Of Development Costs To Cover Per Year |  |  |  |  |  |  | 10,000,000.0 |  |  |  |  |  |
Agreement Amendment Payment Receivable | $ 10,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |
Change In Amount Receivable For Achievement Of Regulatory And Commercial Milestones | $ 25,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones |  |  |  |  |  |  | $ 320,000,000.0 |  |  |  |  |  |
Chiesi Ex US Agreement [Member] | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  |  | 35.00% | 35.00% |  |  |  |  |
Chiesi Ex US Agreement [Member] | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  |  | 15.00% | 15.00% |  |  |  |  |
Kirin Holdings Company, Limited [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Recognized revenues related to non-refundable payment |  |  |  |  | $ 1,000,000.0 |  |  |  |  |  |  |  |
Non-Refundable Future Service Payment |  |  | $ 1,000,000.0 |  |  |  |  |  |  |  |  |  |

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