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SIGNIFICANT ACCOUNTING POLICIES (Additional Information) (Details) |  |  |  |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Jul. 02, 2021 USD ($) | Jun. 07, 2021 shares | Feb. 17, 2021 USD ($) $ / shares shares | Mar. 18, 2020 USD ($) $ / shares shares | Jul. 23, 2018 USD ($) | Oct. 19, 2017 USD ($) | Oct. 31, 2015 | Dec. 31, 2021 USD ($) item $ / shares shares | Dec. 31, 2020 USD ($) $ / shares shares | Dec. 31, 2019 shares | Aug. 25, 2021 $ / shares | Dec. 01, 2016
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 |  |  |
Shares Issued, Price Per Share | $ / shares |  |  | $ 4.60 |  |  |  |  |  |  |  |  |
Share price | $ / shares |  |  | $ 4.60 |  |  |  |  |  |  |  |  |
Gross proceeds |  |  | $ 40,200,000 |  |  |  |  | $ 8,575,000 | $ 4,867,000 |  |  |
Number of shares issued (in shares) | shares |  |  | 8,749,999 |  |  |  |  |  |  |  |  |
Proceeds from private placement |  |  |  | $ 41,300,000 |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares |  |  |  |  |  |  |  | 28,502,017 | 22,850,682 | 7,838,120 |  |
Operating Lease, Right-of-Use Asset |  |  |  |  |  |  |  | $ 4,960,000 | $ 5,567,000 |  |  |
Operating Lease, Liability |  |  |  |  |  |  |  | 5,583,000 |  |  |  |
Accounts receivable - Trade |  |  |  |  |  |  |  | 3,442,000 | $ 2,000,000 |  |  |
Fiocruz [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable - Trade |  |  |  |  |  |  |  | 2,200,000 |  |  |  |
Chiesi [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Accounts receivable - Trade |  |  |  |  |  |  |  | $ 1,200,000 |  |  |  |
2021 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Interest rate (as a percent) |  |  |  |  |  |  |  | 7.50% |  |  | 7.50% | 7.50%
Aggregate principal amount |  |  |  |  |  |  |  | $ 0 |  |  |  |
2024 Notes |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 0.001 |
Interest rate (as a percent) |  |  |  |  |  |  |  | 7.50% |  |  | 7.50% |
Aggregate principal amount |  |  |  |  |  |  |  | $ 28,750,000 |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Tax Rate Assumption Related To Deferred Tax Difference Reversal |  |  |  |  |  |  |  | 23.00% |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Tax Rate Assumption Related To Deferred Tax Difference Reversal |  |  |  |  |  |  |  | 21.00% |  |  |  |
Amended Pfizer Agreement | Protalix Bio Therapeutics Incorporation [Member] | Brazil [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement Revenues Expenses Sharing Percentage |  |  |  |  |  |  | 100.00% |  |  |  |  |
Chiesi US Agreement and Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable Payment Receivable |  |  |  |  |  | $ 25,000,000.0 |  | $ 50,000,000.0 |  |  |  |
Revenue, Performance Obligation, Number | item |  |  |  |  |  |  |  | 2 |  |  |  |
Chiesi US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable Payment Receivable |  |  |  |  | $ 25,000,000.0 | 25,000,000.0 |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  | $ 20,000,000.0 |  |  |  |  |  |  |
Chiesi US Agreement [Member] | Minimum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  | 15.00% |  |  | 15.00% |  |  |  |
Chiesi US Agreement [Member] | Maximum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  | 40.00% |  |  | 40.00% |  |  |  |
Chiesi Ex US Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable Payment Receivable |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |
Additional Amounts Payable To Cover Development Costs |  |  |  |  |  | $ 25,000,000.0 |  |  |  |  |  |
Chiesi Ex US Agreement [Member] | Minimum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 15.00% |  | 15.00% |  |  |  |
Chiesi Ex US Agreement [Member] | Maximum |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payment On Net Sales Percentage |  |  |  |  |  | 35.00% |  | 35.00% |  |  |  |
ATM Shares |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Sale Of Stock Maximum Offering Price | $ 20,000,000.0 |  |  |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) | shares |  |  |  |  |  |  |  | 0 |  |  |  |
Private Placement |  |  |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share price | $ / shares |  |  |  | $ 2.485 |  |  |  |  |  |  |  |
Number of shares issued (in shares) | shares |  | 173,816 |  | 17,604,423 |  |  |  |  | 200,000 |  |  |
Purchase price (in dollars per share) | $ / shares |  |  |  | $ 2.485 |  |  |  |  |  |  |  |
Number of warrants issued (in shares) | shares |  |  |  | 17,604,423 |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ / shares |  |  |  | $ 2.36 |  |  |  |  |  |  |  |
Exercise of warrants, commencement period |  |  |  | 6 months |  |  |  |  |  |  |  |
Term of warrants |  |  |  | 5 years |  |  |  |  |  |  |  |
Proceeds from private placement |  |  |  | $ 43,700,000 |  |  |  |  |  |  |  |

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