    <SEC-DOCUMENT>0001104659-22-053664-index.html : 20220429
    <SEC-HEADER>0001104659-22-053664.hdr.sgml : 20220429
    <ACCEPTANCE-DATETIME>20220429163658
    ACCESSION NUMBER:		0001104659-22-053664
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		5
    CONFORMED PERIOD OF REPORT:	20220630
    FILED AS OF DATE:		20220429
    DATE AS OF CHANGE:		20220429

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Protalix BioTherapeutics, Inc.
    		CENTRAL INDEX KEY:			0001006281
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				650643773
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-33357
    		FILM NUMBER:		22876348

    	BUSINESS ADDRESS:
    		STREET 1:		2 UNIVERSITY PLAZA
    		STREET 2:		SUITE 100
    		CITY:			HACKENSACK
    		STATE:			NJ
    		ZIP:			07601
    		BUSINESS PHONE:		201-696-9345

    	MAIL ADDRESS:
    		STREET 1:		2 UNIVERSITY PLAZA
    		STREET 2:		SUITE 100
    		CITY:			HACKENSACK
    		STATE:			NJ
    		ZIP:			07601

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ORTHODONTIX INC
    		DATE OF NAME CHANGE:	19980422

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	EMBASSY ACQUISITION CORP
    		DATE OF NAME CHANGE:	19960124
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>tm2213754-1_def14a.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: tm2213754-1_def14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>lg_protalix-4c.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: lg_protalix-4c.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>sg_eyalrubin-bw.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: sg_eyalrubin-bw.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>tm2213754d1-px_page01bwlr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: tm2213754d1-px_page01bwlr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>tm2213754d1-px_page02bwlr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: tm2213754d1-px_page02bwlr.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>