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v3.22.4

SUBSEQUENT EVENTS (Details) - USD ($) $ in Thousands |  |  |  |  | 2 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | ---
Feb. 07, 2023 | Jan. 15, 2023 | Jan. 12, 2023 | Feb. 17, 2021 | Feb. 28, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Issuance of common stock under the Sales Agreement, net |  |  |  |  |  | $ 8,236 | $ 8,575 | $ 4,867
Number of shares issued (in shares) |  |  |  | 8,749,999 |  |  |  |
Over-Allotment Option |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Number of shares issued (in shares) |  |  |  | 1,141,304 |  |  |  |
Subsequent Event |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Issuance of common stock under the Sales Agreement, net |  |  |  |  | $ 5,500 |  |  |
Issuance of common stock under the Sales Agreement, net (in shares) |  |  |  |  | 3,590,813 |  |  |
Subsequent Event | Pfizer Agreement [Member] |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Proceeds From Sale Of Products |  | $ 1,100 |  |  |  |  |  |
Subsequent Event | Chiesi Agreements |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Proceeds from expense reimbursements |  |  | $ 1,100 |  |  |  |  |
Subsequent Event | Brazil Agreement with Fiocruz | Alfataliglicerase |  |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |  |
Proceeds From Sale Of Products | $ 2,300 |  |  |  |  |  |  |

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