EXHIBIT 31.1

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CERTIFICATION

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I, Dror Bashan, certify that:

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1.    I have reviewed this Annual Report on Form 10-K/A of Protalix BioTherapeutics, Inc.;

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2.    Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

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Dated: May 1, 2023

/s/ Dror Bashan

Dror Bashan

President and Chief Executive Officer

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