    <SEC-DOCUMENT>0001558370-23-010262-index.html : 20230519
    <SEC-HEADER>0001558370-23-010262.hdr.sgml : 20230519
    <ACCEPTANCE-DATETIME>20230519165602
    ACCESSION NUMBER:		0001558370-23-010262
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230519
    DATE AS OF CHANGE:		20230519
    EFFECTIVENESS DATE:		20230519

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Protalix BioTherapeutics, Inc.
    		CENTRAL INDEX KEY:			0001006281
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				650643773
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-33357
    		FILM NUMBER:		23941180

    	BUSINESS ADDRESS:
    		STREET 1:		2 UNIVERSITY PLAZA
    		STREET 2:		SUITE 100
    		CITY:			HACKENSACK
    		STATE:			NJ
    		ZIP:			07601
    		BUSINESS PHONE:		201-696-9345

    	MAIL ADDRESS:
    		STREET 1:		2 UNIVERSITY PLAZA
    		STREET 2:		SUITE 100
    		CITY:			HACKENSACK
    		STATE:			NJ
    		ZIP:			07601

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ORTHODONTIX INC
    		DATE OF NAME CHANGE:	19980422

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	EMBASSY ACQUISITION CORP
    		DATE OF NAME CHANGE:	19960124
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>plx-20221231xars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: plx-20221231xars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>