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SIGNIFICANT ACCOUNTING POLICIES (Details) $ / shares in Units, $ in Thousands |  |  |  |  | 1 Months Ended | 3 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Aug. 29, 2022 | May 13, 2021 USD ($) | Jul. 23, 2018 USD ($) | Oct. 19, 2017 USD ($) | Oct. 31, 2015 | Mar. 31, 2024 USD ($) agreement $ / shares shares | Mar. 31, 2023 USD ($) shares | Dec. 31, 2023 USD ($) $ / shares | Feb. 27, 2023 USD ($) | Jul. 02, 2021 USD ($) $ / shares
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Number of global licensing and supply agreements | agreement |  |  |  |  |  | 2 |  |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  |  |  |  |  | $ 0.001 |  | $ 0.001 |  |
Stock issuance proceeds |  |  |  |  |  |  | $ 14,233 |  |  |
Aggregate principal amount |  |  |  |  |  | $ 20,420 |  | $ 20,251 |  |
Antidilutive securities excluded from computation of earnings per share, amount | shares |  |  |  |  |  | 31,839,345 | 36,292,208 |  |  |
Accumulated deficit |  |  |  |  |  |  |  | $ 381,549 |  |
ATM Shares |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) | shares |  |  |  |  |  |  | 13,980,060 |  |  |
Common Stock, Par or Stated Value Per Share | $ / shares |  |  |  |  |  |  |  |  |  | $ 0.001
Sale of stock, maximum offering price |  |  |  |  |  | $ 6,400 |  |  | $ 20,000 | $ 20,000
Stock issuance proceeds |  |  |  |  |  |  | $ 20,000 |  |  |
2024 Notes |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Interest rate (as a percent) |  |  |  |  |  | 7.50% |  |  |  |
Minimum cash balance required |  |  |  |  |  | $ 7,500 |  |  |  |
Amended Pfizer Agreement | Protalix Bio Therapeutics Incorporation | Brazil |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Collaborative arrangement revenues and expenses sharing percentage |  |  |  |  | 100.00% |  |  |  |  |
Chiesi Agreements |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Amount of milestone payment received |  |  |  |  |  | $ 20,000 |  |  |  |
Chiesi US Agreement |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Additional amounts payable to cover development costs |  |  | $ 20,000 |  |  |  |  |  |  |
Additional amount payable for achievement of regulatory and commercial milestones |  |  | $ 760,000 |  |  |  |  |  |  |
Chiesi US Agreement | Minimum |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Payment on net sales percentage |  |  | 15.00% |  |  |  |  |  |  |
Chiesi US Agreement | Maximum |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Payment on net sales percentage |  |  | 40.00% |  |  |  |  |  |  |
Chiesi Ex-US Agreement |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Additional amounts payable to cover development costs |  |  |  | $ 25,000 |  |  |  |  |  |
Agreement amendment payment receivable |  | $ 10,000 |  |  |  |  |  |  |  |
Change in amount receivable for achievement of regulatory and commercial milestones |  | $ 25,000 |  |  |  |  |  |  |  |
Additional amount payable for achievement of regulatory and commercial milestones |  |  |  | $ 320,000 |  |  |  |  |  |
Chiesi Ex-US Agreement | Minimum |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Payment on net sales percentage |  |  |  | 15.00% |  |  |  |  |  |
Chiesi Ex-US Agreement | Maximum |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Payment on net sales percentage |  |  |  | 35.00% |  |  |  |  |  |
Chiesi US Agreement and Chiesi Ex-US Agreement |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Non-refundable payment receivable |  |  | $ 25,000 | $ 25,000 |  |  |  |  |  |
Fill/Finish Agreement |  |  |  |  |  |  |  |  |  |
Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Extended term of agreement | 7 years |  |  |  |  |  |  |  |  |

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