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<SEC-DOCUMENT>0000950123-10-063846.txt : 20110211
<SEC-HEADER>0000950123-10-063846.hdr.sgml : 20110211
<ACCEPTANCE-DATETIME>20100706201840
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0000950123-10-063846
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20100706

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			STEMCELLS INC
		CENTRAL INDEX KEY:			0000883975
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				943078125
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		3155 PORTER DRIVE
		STREET 2:		.
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
		BUSINESS PHONE:		6504753100

	MAIL ADDRESS:	
		STREET 1:		3155 PORTER DRIVE
		STREET 2:		.
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CYTOTHERAPEUTICS INC/DE
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
<FILENAME>filename1.htm
<TEXT>
<HTML>
<HEAD>
<TITLE>corresp</TITLE>
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<DIV style="font-family: Helvetica,Arial,sans-serif">


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><IMG src="f56300f5630001.gif" alt="(STEMCELLS LOGO)">
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">July&nbsp;6, 2010
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U><B>VIA EDGAR</B></U>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Securities and Exchange Commission<BR>
Division of Corporation Finance<BR>
100 F Street, N.E.<BR>
Washington, D.C. 20549-7010

</DIV>

<DIV align="left" style="margin-top: 12pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt; background: transparent; color: #000000">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD></TD>
</TR>
<TR valign="top">
    <TD nowrap align="left">Attention:</TD>
    <TD>&nbsp;</TD>
    <TD>Frank Wyman<BR>
Lisa Vanjoske<BR>
Karen Ubell<BR>
Suzanne Hayes<BR>
Jim B. Rosenberg</TD>
</TR>
</TABLE>
</DIV>

<DIV align="left" style="margin-top: 12pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt; background: transparent; color: #000000">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD></TD>
</TR>
<TR valign="top">
    <TD nowrap align="left"><B>Re:</B></TD>
    <TD>&nbsp;</TD>
    <TD><B>SEC Comment Letter dated June&nbsp;7, 2010</B><BR>
<B>StemCells, Inc.</B><BR>
<B>Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2009</B><BR>
<B>Definitive Proxy Statement on Schedule&nbsp;14A filed April&nbsp;13, 2010</B><BR>
<B>File No.&nbsp;001-19871</B></TD>
</TR>
</TABLE>
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Ladies and Gentlemen:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">On behalf of StemCells, Inc. (the &#147;Company&#148;), this letter is being submitted to the Staff of the
Securities and Exchange Commission (the &#147;Commission&#148;) in response to the comments in the Staff&#146;s
letter dated June&nbsp;7, 2010 (the &#147;June 7 Letter&#148;) regarding the Company&#146;s 10-K for the year ended
December&nbsp;31, 2009 (the &#147;2009 10-K&#148;) and definitive proxy statement filed on April&nbsp;13, 2010 (our
&#147;2010 Proxy Statement&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">For reference purposes, the comments as reflected in the June 7 Letter are reproduced in bold in
this letter, and the corresponding responses of the Company are shown below each comment.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Accordingly, we supplementally advise you as follows:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U><B>Form&nbsp;10-K for the Fiscal Year Ended December&nbsp;31, 2009</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U><B>Item&nbsp;1. Business</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U><B>General</B></U>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>1.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>We note your disclosure in the risk factor titled &#147;The manufacture of cell-based therapeutic
products is novel, regulated, critical to our business and dependent upon specialized key
materials.&#148; Specifically, you state that some of your material requirements are single
sourced and the loss of a source may adversely affect your business. Please identify your
products and product candidates that are dependent on sole source providers and</B></TD>
</TR>

</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV style="font-family: Helvetica,Arial,sans-serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 2

</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>identify the sole source providers. If you have agreements with these parties, file the
agreements and describe the material terms. Alternatively, tell us why you believe you are
not substantially dependent on such agreements.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">While there are over a hundred separate disposables and dozens of media and reagents used in both
the manufacture of a patient dose of HuCNS-SC cells and in the production of cell banks, just a few
of these are single sourced. Some of these are custom made for us under contract, but none of
these are considered material to our business. Also, we do not believe our business is
substantially dependent on any of the single sourced materials because each could be replaced by
alternative technologies or provided by separately engaged manufacturers upon our request. We
believe we have a sufficient supply of all key materials in inventory to prepare the patient doses
needed to complete our currently active clinical trials.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Nevertheless, while we believe our supply chain risks are manageable, replacing technologies in a
highly regulated manufacturing process such as ours could entail additional cost and time and would
have the potential to delay one or more of our planned clinical trials.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U><B>Marketing, page 12</B></U>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>2.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>We note that you have distribution agreement with Millipore Corporation for the marketing and
sale of certain cell culture products. If you are substantially dependent on an agreement
with Millipore for the sale of your products, please file the agreement and describe the
material terms of the agreement. If you believe you are not substantially dependent on an
agreement with Millipore, please provide us with an analysis supporting your determination.
Your analysis should address the percentage of product sales that are attributable to the
agreement.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We discuss our arrangement with Millipore Corporation because we believe it indicates the potential
for our cell culture products and represents one potential pathway to the commercialization of
these technologies. However, we are principally a research and development company and none of our
product development efforts are substantially dependent on any revenues from, or on our
relationship with, Millipore. Our arrangement with Millipore is essentially a licensing one from
which we receive a percentage of Millipore&#146;s net sales of certain identified products, all of which
are manufactured by Millipore. None of these revenues are material to our business, and presently
we view our current revenues as an incremental offset to our principal business expenditures
related to our research, development, and commercialization of stem cell therapeutics and related
enabling technologies.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U><B>Patents, Property Rights and Licenses, page 12</B></U>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>3.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Please clarify which patents you own and which you license from other parties. Please also
disclose when each patent identified expires.</B></TD>
</TR>




</TABLE>
</DIV>
<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV style="font-family: Helvetica,Arial,sans-serif">


<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 3

</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Of the eighteen patents identified on pages 12-13 of our 2009 10-K as being amongst our
&#147;significant&#148; patents, eight are owed by us and ten are exclusively licensed to us. The table
below sets out the anticipated expiration dates of these patents absent the grant of any patent
term extension, whether under the Hatch Waxman Act (Pub. L. 98-417) or otherwise, which information
will be included in our future 10-K filings:
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="20%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="75%">&nbsp;</TD>
</TR>
<TR></TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Patents Owned:
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">5,968,829 (2017); 7,153,686 (2019);
6,777,233 (2017); 6,468,794 (2019);
6,238,922 (2019); 7,049,141 (2019);
7,211,404 (2022); 7,381,561
(2024)&#091;note this patent was
incorrectly identified in our 2009
10-K as U.S. Pat. No.&nbsp;7,381,261&#093;</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Patents Exclusively Licensed<BR>
(licensor included):
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">7,361,505 (NeuroSpheres, 2017);
6,497,872 (NeuroSpheres, 2019);
5,851,832 (NeuroSpheres, 2015);
6,294,346 (NeuroSpheres, 2018);
7,005,299 (University of Edinburgh,
2014); 6,150,169 (University of
Edinburgh, 2014); 6,878,542
(University of Edinburgh, 2014);
7,256,041 (University of Edinburgh,
2014); 6,146,888 (University of
Edinburgh, 2014); 7,371,573
(University of Edinburgh, 2019)</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Licenses with Research Institutions, page 14</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>4.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>We note your reference to a license agreement with Oregon Health &#038; Science University on page
14. Additionally, we note the reference to your collaborators at OHSU Casey Eye Institute on
page 40. Please provide a discussion of the material terms of your collaboration and license
agreements with OHSU and either file the agreements or provide us with an analysis supporting
your determination that you are not required to file them.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We view our relationships with many of our collaborators as indicators of the potential of our
research and development efforts and of our technologies. Our partners in these efforts, such as
Oregon Health &#038; Science University and OHSU Casey Eye Institute, are considered by many as leading
centers of research excellence and therefore helpful in demonstrating to investors the progress and
potential of our programs. We believe this is also true with respect to many of our licensing
relationships, particularly with academic centers of excellence such as Cambridge University and
the RIKEN Institute.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Despite the fact that we view these relationships as helpful information for investors to
understand the breadth and sophistication of our collaboration partners, in most instances we do
not view the contractual aspects of these relationships as material. This is true for Oregon
Health &#038; Science University, OHSU Casey Eye Institute, Cambridge University, and the RIKEN
Institute, for example. In all these cases, the ongoing financial obligations with these parties
are not material. Likewise, the work performed or the licenses granted under these agreements are
not material to our business. We consider our relationships with these entities to be part of our
ordinary course of business given that we are engaged in the development and commercialization of
stem cell therapeutics and enabling technologies for stem cell-based research and drug discovery
and development.
</DIV>





<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<DIV style="font-family: Helvetica,Arial,sans-serif">




<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 4

</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>5.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>With respect to your license agreement with the University of Edinburgh, please also disclose
the royalty range (single digits, twenties, thirties, etc.), the minimum annual payments and
when the agreement expires.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">In future filings, we will summarize the termination provisions of our license agreement with the
University of Edinburgh, dated as of January&nbsp;31, 2006 (the &#147;Edinburgh License Agreement&#148;).
Essentially the agreement is terminable by either party upon the other party&#146;s material breach as
well as terminable by the University of Edinburgh in the event of our bankruptcy.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">With respect to minimum annual payments owed, we respectfully advise the Staff that we consider the
royalty payments with the University of Edinburgh to be confidential information for the reasons
set forth in the confidential treatment request we filed with the
Commission on March&nbsp;11, 2010 in respect
of the Edinburgh License Agreement, which was granted effective April&nbsp;20, 2010. We continue to
believe that disclosing the royalty rate or a range of royalty rates would result in competitive
harm to the Company.
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>6.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Please include a description of your agreements with Cambridge University and RIKEN
Institute. Your discussion should include:</B></TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>the nature of the agreement;</B></TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>products or product candidates dependent on the agreement;</B></TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>each party&#146;s rights and obligations;</B></TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>payment provisions, including payments made to date, aggregate potential
milestone payments, minimum annual payments, royalty rates or a range of
royalty rates; and term and termination provisions.</B></TD>
</TR>

</TABLE>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 4%"><B>Additionally, please file the agreements or provide an analysis supporting your
determination that you are not substantially dependent on each agreement.</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We refer the Staff to our response to Comment 4. We believe that these agreements are not
material, although we consider identifying the relationships with these entities as helpful
information for investors to understand the breadth and sophistication of our collaboration
partners. Accordingly, we have described the basic subject matter of our agreements with these
parties in our filings.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Licenses with Commercial Entities, page 14</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>7.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>With respect to your agreement with NeuroSpheres, please disclose when the patents licensed
to you are scheduled to expire and a range of royalty rates payable under the license
agreement.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">In future filings, we will identify the significant patents we have licensed from NeuroSpheres and
disclose the expiration dates of these patents. However, we respectfully advise the Staff that we
consider the royalty payments with NeuroSpheres to be confidential
</DIV>




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</DIV>

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<DIV style="font-family: Helvetica,Arial,sans-serif">




<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 5

</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">information
for the reasons set forth in the confidential treatment request filed
with the Commission in
March&nbsp;2001 and later granted in respect of the License Agreement, dated as of October&nbsp;30, 2000,
between the Company and NeuroSpheres Holdings Ltd. We continue to believe that disclosing these
royalty rates, even as a range of royalty rates, would result in competitive harm to the Company.
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>8.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>With respect to your agreement with Stem Cell Therapeutics, please disclose aggregate
payments to date, aggregate potential milestone payments, applicable royalty range and term
and termination provisions.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We respectfully advise the Staff that we do not consider our agreement with Stem Cell Therapeutics
to be material. This is one of several license agreements entered into by us in the ordinary
course of business to grant non-exclusive rights to practice one or more technologies covered by
some of our patents in order to pursue activities that are not central to our business strategy of
developing and commercializing cell-based therapeutics. In this case, the license covers three
patent families and allows Stem Cell Therapeutics to use erythropoietin in combination with a
proliferating agent to modulate or stimulate endogenous neural stem cells for the treatment of
certain CNS diseases and disorders. Total revenue under this license will be contingent upon the
clinical and commercial success of Stem Cell Therapeutics. We do not consider the annual fees or
likely near-term revenues under this license to be material.
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>9.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Please describe the terms of your license of your IRES technology to a &#147;major international
pharmaceutical company.&#148; Your discussion should identify the licensor, quantify payments made
to date and aggregate potential payments, and describe term and termination provisions.
Please also file the agreement or provide us with an analysis supporting your determination
that you are not required to file the agreement.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We respectfully advise the Staff that we do not consider our agreement with this pharmaceutical
company for IRES technology to be material. This is one of several license agreements entered into
by us in the ordinary course of business to grant non-exclusive rights to practice one or more
technologies covered by some of our patents in order to pursue activities that are not central to
our business strategy of developing and commercializing cell-based therapeutics. In this case, the
license covers just one patent family and allows the pharmaceutical company to engage in certain
internal research activities not related to stem cell therapeutics. The license is now fully-paid
up and the total revenues received under this license were immaterial.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Management&#146;s Discussion and Analysis of Financial Condition and Results of Operations</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>Liquidity and Capital Resources, page 49</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B><I>Indemnification Agreement</I></B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>10.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>You have capitalized $750,000 of litigation cost reimbursements to NeuroSystems as &#147;Other
assets non-current&#148; due to your right of offset</B></TD>
</TR>

</TABLE>
</DIV>

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<DIV style="font-family: Helvetica,Arial,sans-serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 6

</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>against future maintenance fees, milestones and royalties to be owed under the related
license agreements with this commercial entity. Your assertion that this amount is a fair
estimate of your future obligations to NeuroSystems appears to be premised on the future
commercialization of the associated products and technologies. However, on page 23, you
assert that these products and technologies are only in the early stages of discovery and
development, are inherently risky and may not ever achieve commercialization. Please
explain to us this apparent contradiction. Also, tell us why you believe that deferral of
these litigation cost reimbursements complies with GAAP with reference to the authoritative
literature upon which you based your conclusion.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Pursuant to a previously filed agreement amending our license agreements with NeuroSpheres, we are
entitled to off-set all litigation costs incurred in our patent infringement suit against
Neuralstem (discussed on page 32,<I>&#147;Item&nbsp;3. Legal proceedings&#148; </I>and page 79, <I>&#147;Contingencies&#148;</I>) against
amounts that would otherwise be owed to NeuroSpheres under these license agreements, such as annual
maintenance fees, milestones and royalty payments. We have capitalized $750,000 of our litigation
costs in this lawsuit because we will use these costs to offset the $50,000 asset-based royalty
payment we are contractually obligated to pay NeuroSpheres each year. The $750,000 capitalized was
not premised on future commercialization of products or technologies but rather on annual payments
to the farthest expiry date of our license agreements with NeuroSpheres.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Because these annual payments of $50,000 are fully creditable against royalties due to
NeuroSpheres, we have classified the $750,000 as part of prepaid royalties under &#147;Other Assets.&#148;
We will clarify this disclosure in future filings. We set forth below what we consider the
applicable accounting guidance in the GAAP Literature:
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Concept 6:</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>Assets</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">25. Assets are probable future economic benefits obtained or controlled by a particular entity
as a result of past transactions or events.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Characteristics of Assets</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">26. An asset has three essential characteristics: (a)&nbsp;it embodies a probable future benefit that
involves a capacity, singly or in combination with other assets, to contribute directly or
indirectly to future net cash inflows, (b)&nbsp;a particular entity can obtain the benefit and control
others&#146; access to it, and (c)&nbsp;the transaction or other event giving rise to the entity&#146;s right to
or control of the benefit has already occurred.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Accrual and Deferral (Including Allocation and Amortization)</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">141. Accrual accounting attempts to recognize noncash events and circumstances as they occur and
involves not only accruals but also deferrals, including allocations and amortizations. Accrual is
concerned with expected future cash receipts and payments: it is the accounting process of
recognizing assets or liabilities and the related liabilities, assets, revenues, expenses, gains,
or losses for amounts expected to be received or paid, usually in cash, in the future. Deferral is
concerned with past cash receipts and payments&#151;with prepayments received (often described as
collected in advance) or paid: it is the accounting
</DIV>




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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 7

</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">process of recognizing a liability resulting from a current cash receipt (or the equivalent) or an
asset resulting from a current cash payment (or the equivalent) with deferred recognition of
revenues, expenses, gains, or losses. Their recognition is deferred until the obligation underlying
the liability is partly or wholly satisfied or until the future economic benefit underlying the
asset is partly or wholly used or lost. Common examples of accruals include purchases and sales of
goods or services on account, interest, rent (not yet paid), wages and salaries, taxes, and
decreases and increases in marketable securities accounted for at lower of cost and market. Common
examples of deferrals include prepaid insurance and unearned subscriptions.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Contractual Obligations, page 53</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>11.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Please include the wind-down expense liability in this table, as well as estimated license
fee and milestone payments under your arrangements with research institutions and commercial
entities.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response, Wind-down expense liability:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">The lease payment obligations that are part of the wind-down reserve are already included in the
table under the caption &#151; <I>&#147;Operating lease payments.&#148; </I>The remainder of the wind-down expense
liability is estimated day-to-day operating expenses. The caption includes a footnote that refers
to &#147;Operating Leases&#148; on page 52 of the 2009 10-K for further information. In future filings, we
will modify the footnote (and disclose the same in our next 10-Q filing &#151; quarter ending June&nbsp;30,
2010) to read:
</DIV>



<DIV align="left" style="font-size: 10pt; margin-top: 6pt; margin-left: 2%">&#147;(1) Operating lease payments exclude space-sharing and sublease income but include rent
payments for our Rhode Island facility that are included as part of our &#147;Accrued wind-down
expenses&#148; in our Consolidated Financial Statements. See Note XX &#147;Wind-down and exit costs&#148;
and Note XX &#147;Commitments and Contingencies&#148; in the notes to condensed consolidated financial
statements of Part&nbsp;I, Item&nbsp;1 of this Form 10-Q for further information.&#148;
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response, Milestone payments:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Milestone payments under our licensing arrangements with other entities are not included in the
table of contractual obligations because these arrangements either: i) do not fall within the
definition of captions under contractual obligations as defined in Regulation&nbsp;S-K under Item. 303
(5) (Long-Term Debt Obligations, Capital Lease Obligations, Operating Lease Obligations, Purchase
Obligations and Other Long-Term Liabilities); ii) are dependent on the occurrence of contingent
events, the timing of which cannot be reasonably estimated; or iii) are immaterial. We will
indicate in future filings, as a footnote to the contractual obligation table, why we do not
disclose these payments.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Statement of Operations, page 59</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="1%" nowrap align="left"><B>12.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>You report gross profit here and in MD&#038;A which includes revenue from licensing agreements and
grants. Please tell us why there are no costs associated with these revenues within the
caption, gross profit.</B></TD>
</TR>

</TABLE>
</DIV>


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<DIV style="font-family: Helvetica,Arial,sans-serif">


<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 8
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Company Response:</U>

</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">The licensing revenues in this line item are shown on a net basis, because the Company has no
direct costs under these license agreements other than, in some instances, fixed royalties owed to
licensors. In such instances, when we have granted sublicenses to patents licensed to us, we
essentially act as an agent under these sublicensing agreements. The direct cost is merely a fixed
percentage of royalty due to the licensor on revenue earned by the sub-licensee and paid to us as
the sub-licensor. There is no service or product provided by the Company under these agreements.
The Company has no discretion in supplier selection. The Company is not involved in the
determination of product or service specifications or any other control over sales by our
sub-licensees. We have no physical loss inventory risk in these instances. For these reasons, we
present this information on a net revenue basis. Reference is made to
GAAP ASC 605-45. In future filings, we will
clarify our revenue recognition method for licensing agreements under Revenue Recognition Policy.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Grant revenue from government agencies are recognized as the related qualified research and
development costs are incurred, up to the approved amount of the grant. Grants are funds received
from the government agencies to cover specific expenses. Terms of the grant do not provide for
profits. For these reasons, a presentation of cost of goods sold of gross margins would not be
meaningful to investors.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Notes to Consolidated Financial Statements</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>Note 5. Acquisition of SCS, page 70</B>

</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>13.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Disclose the nature of the in process research and development assets and tell us how you
determined the useful lives of 13 &#151; 19&nbsp;years.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">In-process research and development assets relate to: 1) the acquisition of certain IP rights not
expected to expire until 2027 related to our program focused on developing engineered rat models of
human disease (our &#147;Transgenic Rat Program&#148;); and 2)&nbsp;the acquisition of certain technology related
to the commercialization of our SC Proven cell culture products and the development and
commercialization of cell-based assay platforms for use in drug discovery and development (our
&#147;Assay Development Program&#148;).
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">At the time of valuation (April&nbsp;2009), the technology related to our Transgenic Rat Program was in
its nascent stage, and therefore we concluded a 19-year remaining useful life was appropriate for
this technology.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">As for our Assay Development Program, at the time of valuation (April&nbsp;2009), we expected to achieve
proof of concept by 2012. Due to the nature of our Assay Development Program patents and
technologies, we expect the technologies to remain useful and relevant within the industry for at
least the 10&nbsp;years following commercial launch of a product or service under our Assay Development
Program. Because these technologies are not expected to begin generating revenue until 2011-2012,
we estimated a remaining useful life for these technologies to be approximately 13&nbsp;years from the
valuation date.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Note 6. Intangible Assets, page 71</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>14.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>It appears from Note 5 that the caption &#147;In process development&#148; in this note includes in
process research and development, customer relationships and developed technology. Explain
why you believe aggregating all those assets into a single asset class is appropriate.</B></TD>
</TR>

</TABLE>
</DIV>
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<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 9
</DIV>

<DIV style="margin-top: 6pt"><TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">



</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><U>Company Response:</U>

</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We have disaggregated this caption in our first quarter 10-Q (ended March&nbsp;31, 2010) and will
prospectively continue to disaggregate the same.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Note 7. Other Assets, page 72</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>15.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Please explain the nature of prepaid royalties and the contractual arrangements governing
these payments. Refer us to the authoritative literature in GAAP upon which you have based
your accounting for this activity.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">For GAAP literature and nature of prepaid royalties please refer to Item&nbsp;10, above.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Note 12. Commitments and Contingencies, page 77</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>16.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Please disclose the terms of your arrangements with research institutions and commercial
entities, particularly those described on pages 14 &#151; 15.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Please see
our responses to Items 6, 7, 8, and 9, above. We will continue to disclose in Note 12
any arrangements with research institutions and commercial entities which we consider material to
our business.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Definitive Proxy Statement filed April&nbsp;13, 2010</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>Executive Compensation</B>

</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>Compensation Discussion and Analysis, page 12</B>

</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>17.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>We note your statement that &#147;We have concluded that our employee compensation programs are
designed with the appropriate balance of risk and reward in relation to our company&#146;s overall
business strategy and do not incentivize executives or other employees to take unnecessary or
excessive risks. As a result, we believe that risks arising from our employee compensation
policies and practices are not reasonably likely to have a material adverse effect on the
company.&#148; Please provide us with an analysis supporting your determination that your
compensation policies and practices do not present risks that are likely to have a material
adverse effect on you or your business.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We believe our compensation practices are simple and straight-forward and consistent with those of
similarly situated research and development companies. In determining that our compensation
policies and practices do not present risks that are likely to have a material adverse effect on
our business, our directors have, from time to time, discussed with management the various pay
practices used to compensate our employees at both the executive and non-executive levels. These
inquiries have included discussions about our
</DIV>
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<DIV style="font-family: Helvetica,Arial,sans-serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 10
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">three primary components of compensation, namely base
compensation, equity incentive compensation and cash bonuses.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Our Board of Directors has periodically considered how bonus awards are determined and calculated
by the Company, noting that all bonuses are awarded entirely at the discretion of our Board after
taking into consideration the progress of our Company&#146;s programs. Based on its review, our Board
has concluded that our cash bonus program properly aligns compensation with our overall company
goals, all of which are designed to have a positive impact on our business.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">In addition, our Board has periodically examined our equity compensation practices, noting that we
typically grant customary equity awards that vest over many years after the date of grant. We
believe discretionary equity compensation that vests over multiple years does not encourage short
term or high-risk opportunistic behavior and instead aligns our employees&#146; interests with the
long-term interests of our stockholders by encouraging activities intended to build Company
long-term value.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Compensation of Named Executive Officers</B>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 6pt"><B>Bonus Compensation, page 13</B>

</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>18.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>We note your general description of the corporate goals on page 14. To the extent the
corporate goals were quantified or more specifically defined, the discussion should be
expanded to provide a similar level of detail. For example:</B></TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Were there any specific activities aimed at initiating clinical trials of
HuCNS-SC or any other items constituting progress in your CNS Program;</B></TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Was progress in your Liver Program further defined; and</B></TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="4%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Were any other corporate development activities identified?</B></TD>
</TR>

</TABLE>
</DIV>

<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>Additionally, discuss the extent to which each goal was achieved and how the bonus award of
70% was determined.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U>Company Response:</U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">For each fiscal year, our executive officers present the Compensation Committee of the Board with
approximately five to ten proposed corporate goals, each often consisting of multiple sub-parts.
Typically these goals will include some pre-clinical and clinical goals for our HuCNS-SC cell
product candidate as well as pre-clinical goals for hLEC. Our corporate goals will also typically
include financing and corporate development goals. While all these goals are considered important,
and we use a cross-functional and balanced approach to setting them, we typically prioritize our
goals by assigning relative weightings to each of them, and with all of them together adding up to
100%. However, by design, no one goal ever accounts for a majority of the relative weightings.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Management&#146;s recommendations for these corporate goals are usually presented to the Compensation
Committee concurrent with our proposed corporate budgets for a given fiscal year. The committee
members will review management&#146;s recommendations with our executive officers and often provide
suggestions for additional goals or changes to the recommended goals. After our executive officers
and directors complete this iterative
</DIV>
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<DIV style="font-family: Helvetica,Arial,sans-serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 11
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">process, which often takes several weeks, the Compensation
Committee will adopt revised corporate goals consistent with the foregoing principles. The
Compensation Committee then recommends the updated corporate goals to the full Board for
consideration and approval.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">During each fiscal year, our executive officers will use the Board-approved corporate goals as a
management tool, for example to coordinate activities, motivate personnel and help prioritize the
use of Company resources. The executive officers will sometimes refer back to the corporate goals
when providing business updates to the Board, similar to management&#146;s reference back to an approved
annual budget.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">At the end of each fiscal year, our Chief Executive Officer will present the Compensation Committee
with his assessments of corporate performance against the Board-approved corporate goals, together
with a summary of any important factors that weighed in his assessments, which he provides as
context. Our corporate goals have not been formulaic or quantitative in nature (we have not had a
corporate goal tied to specific stock price, revenues or expenses, for example), so our CEO&#146;s
assessments have been largely qualitative in nature. Along with these assessments, our CEO will
provide a percentage score for each goal reflecting the degree to which each goal was or was not,
in his judgment, achieved during the year.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">The Compensation Committee has usually considered these percentage scores as well as our Chief
Executive Officer&#146;s commentary about corporate performance and more general assessments of the
state of our business when determining whether to award employees a company-wide corporate bonus in
any given year, and if so how much of the available bonus pool to award. However, the Compensation
Committee members will use their own judgment to determine the size of any bonus award, if any.
Therefore, there is no known direct correlation between the aggregate percentage score given to any
year&#146;s corporate goals by our CEO and the ultimate bonus payout.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">In 2010, the Compensation Committee awarded a discretionary bonus equal to 70% of the available
bonus pool, based upon the committee members&#146; assessments of market conditions, corporate risks,
Company successes in 2009, employee compensation more generally, and our market comparables, among
other things, including the committee member&#146;s qualitative
assessments of the Company&#146;s performance
in 2009 measured against its 2009 corporate goals.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">For the above reasons, we believe our 2010 Proxy Statement, when taken together with our other
public filings, disclose all material information necessary to allow investors and potential
investors in the Company to understand the significant types of measures and considerations used by
our Board in determining whether to award a discretionary bonus to Company employees, including our
executive officers. We explained, for example, that some of our 2009 corporate goals related to
(i)&nbsp;progress in our CNS Program, including activities aimed at initiating clinical trials of our
HuCNS-SC proprietary cell-based product in multiple therapeutic indications; (ii)&nbsp;progress in our
Liver Program; (iii)&nbsp;successful financing efforts; (iv)&nbsp;successful corporate development
activities; and (v)&nbsp;advancement of our scientific development programs. In our view, the
particular goals, as well as their sub-parts and relative weightings, are themselves not material
and describing any of them in greater detail would not provide stockholders or investors with a
more fulsome understanding of our compensation practices or possible future bonus payments under
our discretionary bonus program. Indeed, we believe that disclosure of these particularities would
distract from our overall discussion of compensation objectives without providing material
insights, and could be misunderstood by analysts, stockholders and the investing
</DIV>
<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: Helvetica,Arial,sans-serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 12
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">public, given that
the goals are meant to be aspirational and are not intended as projections or as forecasts of
Company operations.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Proposal Number 1, Election of Directors, page 25</B>
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="3%" nowrap align="left"><B>19.</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD><B>In accordance with newly revised </B><B>Item 401(e)</B><B> of Regulation&nbsp;S-K, please provide disclosure
discussing for each director and director nominee, on an individual basis, the particular
experience, qualifications, attributes or skills that led the company&#146;s board to conclude that
the person should serve as a director of the company.</B></TD>
</TR>

</TABLE>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><U><B>Company Response:</B></U>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">In future filings, we will add disclosure to address these disclosure requirements substantially
similar to the following:
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">The Company&#146;s Nominating Committee and Board seek to nominate and appoint candidates to the Board
who have significant business experience, technical expertise or personal attributes, or a
combination of these, sufficient to suggest, in the Board&#146;s judgment, that the candidate would have
the ability to help direct the affairs of the Company and enhance the Board as a whole. The Board
also considers past service on the Board or on the board of directors of other publicly traded or
technology focused companies.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We believe each of our directors brings valuable skills, experience, judgment, and perspectives to
our Company. The Board took the following qualifications into consideration, among other things,
when appointing our current directors:
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="25%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="70%">&nbsp;</TD>
</TR>
<TR></TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Eric Bjerkholt
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Mr. Bjerkholt is a financial expert and
currently serves as the Senior Vice President
and Chief Financial Officer of Sunesis
Pharmaceuticals, Inc., a biopharmaceutical
company. His business experience spans
approximately 20&nbsp;years, during which time he
founded a nutraceutical company and worked as an
investment banker. Mr.&nbsp;Bjerkholt currently
serves on the board of directors of Round Table
Pizza. We believe Mr.&nbsp;Bjerkholt&#146;s
qualifications to serve on our Board of
Directors include his considerable financial and
business experience, especially in the life
sciences industry. Mr.&nbsp;Bjerkholt has served on
our Board for over six years.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Scott Greer
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Mr. Greer was appointed to our Board in June
2010. He is a financial expert with over 25
years of experience in the life sciences
industry. He was founder, CEO and Chairman of
Abgenix, Inc., a biotechnology company he took
public in 1998 and then sold to Amgen in 2006.
Mr.&nbsp;Greer currently serves as Chairman of
Ablexis and Acologix, both development stage
biotechnology companies, and is also on the
boards of Nektar Therapeutics and BAROnova. We
believe Mr.&nbsp;Greer&#146;s qualifications to serve on
our Board of Directors include his more than 25&nbsp;years of
experience in the life sciences industry.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Ricardo Levy, PhD
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Dr. Levy has over 30&nbsp;years of experience leading
technology companies in both North and South
America. In 1974, he</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: Helvetica,Arial,sans-serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 13
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="25%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="70%">&nbsp;</TD>
</TR>
<TR></TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">cofounded Catalytica,
Inc., a manufacturing technology and components
company. He currently serves as the lead
director of Renegy Holdings, Inc. as well as
director of Accerlys Inc. (formerly
Pharmacopeia, Inc.) and NovoDynamics, Inc. We
believe Dr.&nbsp;Levy&#146;s qualifications to serve on
our Board of Directors include his more than 30&nbsp;years of
business experience. Dr.&nbsp;Levy has served on our
Board for over eight years.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Martin McGlynn
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Mr. McGlynn has been our President and Chief
Executive Officer since January&nbsp;2001. He has
held management positions of increasing
responsibility in several countries for more
than 30&nbsp;years. Prior to joining our Company,
Mr.&nbsp;McGlynn was President and Chief Executive
Officer of Pharmadign, Inc., a privately held
company in the fields of inflammation and
genetic immunization. Prior to this, he was
President and General Manager of Abbott Canada
Ltd. and President of Anaquest, Inc., a company
focused on anesthesia and acute care
pharmaceuticals. We believe Mr.&nbsp;McGlynn&#146;s
qualifications to serve on our Board of
Directors include his significant managerial
experience in our industry and his intimate
knowledge of our operations as a result of his
day to day leadership as our President and Chief
Executive Officer. Mr.&nbsp;McGlynn has served on
our Board for over nine years.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Roger Perlmutter, MD, PhD
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Dr. Perlmutter is the Executive Vice President
of Research and Development of Amgen, Inc., a
world leading biotechnology company, a position
he has held for almost ten years. Prior to
joining Amgen, he held scientific leadership
positions of increasing responsibility at Merck.
He also worked as a researcher and
administrator at the University of Washington.
We believe pharmaceutical industry experience
brings an important industry perspective to the
Board. We believe Dr.&nbsp;Perlmutter&#146;s
qualifications to serve on our Board of
Directors include his experience in both
business and academic research, including his
pharmaceutical industry experience. Dr.
Perlmutter has served on our Board for over nine
years.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">John Schwartz, PhD
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Dr. Schwartz has over 40&nbsp;years of business and
legal experience, including several years spent
in the 1990s as President and Chief Executive
Officer of Systemix, Inc., a cell-based
therapeutics company which was acquired by
Novartis in 1997. Before joining Systemix as
its Senior Vice President and General Counsel in
1993, Dr.&nbsp;Schwartz served as the Vice President
and General Counsel of Stanford University. He
currently runs a registered investment advisor
firm called Quantum Strategies Management
Company. We believe Dr.&nbsp;Schwartz&#146;s
qualifications to serve on our Board of
Directors include his over 40&nbsp;years of business
and legal experience in our industry as well as
his significant experience working at Stanford
University. Dr.&nbsp;Schwartz has served on our
Board for over eleven years.</TD>
</TR>
<TR valign="bottom"><!-- Blank Space -->
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Irving Weissman, MD
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Dr. Weissman has been a leader in the stem cell
field for over twenty years. He is a professor
at Stanford University and</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: Helvetica,Arial,sans-serif">

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">U.S. Securities and Exchange Commission<BR>
July&nbsp;6, 2010<BR>
Page 14
</DIV>

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="25%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="70%">&nbsp;</TD>
</TR>
<TR></TR>
<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">serves as the
director of the Stanford Institute for Stem Cell
Biology and Regenerative Medicine. He
co-founded Systemix in 1988 and Cellerant
Therapeutics, Inc., a hematopoietic stem cell
development company, in 2001. He is a member of
several scientific advisory boards and national
science institutes, including the National
Academy of Science, the American Academy of Arts
and Science, and the American Society of
Microbiology. We believe Dr.&nbsp;Weissman&#146;s
qualifications to serve on our Board of
Directors include the fact that he has been a
leader in stem cell research for over twenty
years as well as his substantial business
experience in our industry. Dr.&nbsp;Weissman has
served on our Board for over twelve years and
serves as the chairman or our Scientific
Advisory Board.</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>


<DIV align="center" style="font-size: 10pt; margin-top: 18pt">********
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Please be advised that, in connection with the Staff&#146;s comments in the June 7 Letter and the
Company&#146;s responses thereto, the Company hereby acknowledges that (i)&nbsp;the Company is responsible
for the adequacy and accuracy of the disclosure in the above-referenced filing; (ii)&nbsp;the Staff&#146;s
comments or changes to disclosure in response to the Staff&#146;s comments do not foreclose the
Commission from taking any action with respect to the filing; and (iii)&nbsp;it is the Staff&#146;s position
that the Company may not assert the Staff comments as a defense in any proceeding initiated by the
Commission or any person under the federal securities laws of the United States.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We hope that the foregoing has been responsive to the Staff&#146;s comments. If you should have any
questions about this letter or require any further information, please call the undersigned at
(650)&nbsp;475-3122.
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt">Very truly yours,
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 18pt">/s/ Kenneth B. Stratton</DIV>

<font style="border-bottom: 1px solid #000000; width: 40%; margin-top: 0pt; font-size: 1pt"></font>

<DIV align="left" style="font-size: 10pt; margin-top: 0pt">Kenneth B. Stratton<BR>
General Counsel
</DIV>



<P align="center" style="font-size: 10pt"><!-- Folio -->&nbsp;<!-- /Folio -->
</DIV>



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`
end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
