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Consolidated Statement of Stockholders' Equity (USD $) | Total | Common Stock | Additional Paid-in Capital | Accumulated Deficit | Accumulated Other Comprehensive Income (Loss)
--- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2008 | $ 21,808,985 |  | $ 949,455 | $ 279,868,802 | $ (259,001,524) | $ (7,748)
Beginning balance, shares at Dec. 31, 2008 |  |  | 9,494,560 |  |  |
Comprehensive loss |  |  |  |  |  |
Net loss | (27,026,411) |  |  |  | (27,026,411) |
Unrealized gain (loss) on foreign currency translation | 272,184 |  |  |  |  | 272,184
Change in unrealized gain (loss) on securities available-for-sale | 130,287 |  |  |  |  | 130,287
Comprehensive loss | (26,623,940) |  |  |  |  |
Issuance of common stock and warrants, net of issuance cost of $1,351,487 and $1,522,083 in 2009 and 2011 respectively, shares |  |  | 1,981,740 |  |  |
Issuance of common stock and warrants, net of issuance cost of $1,351,487 and $1,522,083 in 2009 and 2011 respectively | 26,467,314 |  | 198,174 | 26,269,140 |  |
Common stock issued for acquisition of SCS, shares |  |  | 265,000 |  |  |
Common stock issued for acquisition of SCS | 4,425,500 |  | 26,500 | 4,399,000 |  |
Common stock issued for licensing agreements, shares | 590 |  | 590 |  |  |
Common stock issued for licensing agreements | 10,000 |  | 59 | 9,941 |  |
Common stock issued pursuant to employee benefit plan, shares |  |  | 9,848 |  |  |
Common stock issued pursuant to employee benefit plan | 156,932 |  | 985 | 155,947 |  |
Compensation expense from grant of options, restricted stock units and stock (fair value) | 4,046,339 |  |  | 4,046,339 |  |
Exercise of employee and director stock options, shares |  |  | 31,528 |  |  |
Exercise of employee and director stock options | 252,984 |  | 3,152 | 249,832 |  |
Exercise and net settlement of restricted stock units, shares |  |  | 34,245 |  |  |
Exercise and net settlement of restricted stock units | (380,548) |  | 3,425 | (383,973) |  |
Exercise of warrants, shares |  |  | 17,447 |  |  |
Exercise of warrants | 331,501 |  | 1,745 | 329,756 |  |
Ending balance at Dec. 31, 2009 | 30,495,067 |  | 1,183,495 | 314,944,784 | (286,027,935) | 394,723
Ending balance, shares at Dec. 31, 2009 |  |  | 11,834,958 |  |  |
Comprehensive loss |  |  |  |  |  |
Net loss | (25,243,551) |  |  |  | (25,243,551) |
Unrealized gain (loss) on foreign currency translation | (268,810) |  |  |  |  | (268,810)
Change in unrealized gain (loss) on securities available-for-sale | (6,191) |  |  |  |  | (6,191)
Comprehensive loss | (25,518,552) |  |  |  |  |
Issuance of common stock, net of issuance cost of $480,835, shares |  |  | 847,520 |  |  |
Issuance of common stock, net of issuance cost of $480,835 | 7,279,234 |  | 84,752 | 7,194,482 |  |
Common stock issued pursuant to employee benefit plan, shares |  |  | 18,488 |  |  |
Common stock issued pursuant to employee benefit plan | 232,229 |  | 1,849 | 230,380 |  |
Compensation expense from grant of options, restricted stock units and stock (fair value) | 3,697,405 |  |  | 3,697,405 |  |
Exercise of employee and director stock options, shares |  |  | 3,451 |  |  |
Exercise of employee and director stock options | 19,802 |  | 345 | 19,457 |  |
Exercise and net settlement of restricted stock units, shares |  |  | 53,370 |  |  |
Exercise and net settlement of restricted stock units | (483,406) |  | 5,337 | (488,743) |  |
Stock retired from settlement agreement, shares |  |  | (26,500) |  |  |
Stock retired from settlement agreement | (241,150) | [1] | (2,650) | (238,500) |  |
Ending balance at Dec. 31, 2010 | 15,480,629 |  | 1,273,128 | 325,359,265 | (311,271,486) | 119,722
Ending balance, shares at Dec. 31, 2010 |  |  | 12,731,287 |  |  |
Comprehensive loss |  |  |  |  |  |
Net loss | (21,328,536) |  |  |  | (21,328,536) |
Unrealized gain (loss) on foreign currency translation | 40,032 |  |  |  |  | 40,032
Change in unrealized gain (loss) on securities available-for-sale | (119,041) |  |  |  |  | (119,041)
Comprehensive loss | (21,407,545) |  |  |  |  |
Issuance of common stock and warrants, net of issuance cost of $1,351,487 and $1,522,083 in 2009 and 2011 respectively, shares |  |  | 9,525,116 |  |  |
Issuance of common stock and warrants, net of issuance cost of $1,351,487 and $1,522,083 in 2009 and 2011 respectively | 13,792,340 |  | 187,779 | 13,604,561 |  |
Common stock issued pursuant to employee benefit plan, shares |  |  | 35,164 |  |  |
Common stock issued pursuant to employee benefit plan | 164,896 |  | 1,327 | 163,569 |  |
Compensation expense from grant of options, restricted stock units and common stock (fair value), shares |  |  | 32,631 |  |  |
Compensation expense from grant of options, restricted stock units and stock (fair value) | 3,096,043 |  | 1,267 | 3,094,776 |  |
Exercise of employee and director stock options, shares |  |  | 1,692 |  |  |
Exercise of employee and director stock options | 2,386 |  | 169 | 2,217 |  |
Exercise and net settlement of restricted stock units, shares |  |  | 102,065 |  |  |
Exercise and net settlement of restricted stock units | (403,625) |  | 9,106 | (412,731) |  |
Ending balance at Dec. 31, 2011 | $ 10,725,124 |  | $ 1,472,776 | $ 341,811,657 | $ (332,600,022) | $ 40,713
Ending balance, shares at Dec. 31, 2011 |  |  | 22,427,955 |  |  |
[1] | On April 1, 2009, we acquired the operations of Stem Cell Sciences Plc (SCS, which subsequently changed its name to Asset Realisation Company Limited). As consideration, we issued 265,000 shares of our common stock with a closing price of $16.70 per share and waived certain commitments of SCS to repay approximately $709,000 in principal and accrued interest owed to us. Pursuant to the acquisition agreement, 20% of the 265,000 shares were placed into an escrow for a twelve month period to satisfy any indemnification obligations owed to us by SCS. On August 19, 2010, we entered into a settlement agreement with SCS in which the parties agreed to the release of half the escrowed shares to SCS and half to us in full satisfaction of our claims for indemnification, and both parties waived all other claims, known and unknown, against the other. The 26,500 shares returned to us are being treated as retired and no longer outstanding. We have recorded approximately $227,000 as other income, which was the value of these shares based on the closing price of $9.10 per share on August 19, 2010, and net of amounts already accrued for potential claims against the escrowed shares.

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