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Stock-Based Compensation (Tables)
6 Months Ended
Jun. 30, 2012
Stock-Based Compensation [Abstract]  
Stock-based compensation expense
                                 
    Three months ended
June 30,
    Six months ended
June 30,
 
    2012     2011     2012     2011  

Research and development expense

  $ 320,303     $ 522,958     $ 652,177     $ 961,001  

Selling, general and administrative expense

    403,142       491,305       807,813       987,726  
   

 

 

   

 

 

   

 

 

   

 

 

 

Total employee stock-based compensation

  $ 723,445     $ 1,014,263     $ 1,459,990     $ 1,948,727  
   

 

 

   

 

 

   

 

 

   

 

 

 

Effect on basic and diluted net income (loss) per share

  $ (0.03   $ (0.07   $ (0.06   $ (0.14
   

 

 

   

 

 

   

 

 

   

 

 

 
Stock option activity
                 
    Number of options     Weighted-average
exercise  price ($)
 

Balance at March 31, 2012

    872,032       20.12  

Granted

    —         —    

Exercised

    —         —    

Cancelled

    (17,074     13.22  
   

 

 

         

Outstanding options at June 30, 2012

    854,958       20.26  
   

 

 

         
Summary of changes in unvested options
                         
    Number of options     Weighted-average
exercise price ($)
    Weighted-average
grant

date fair value ($)
 

Unvested options at March 31, 2012

    133,904       11.66       9.34  

Granted

    —         —         —    

Vested

    (18,079     12.13       9.79  

Cancelled

    (11,832     11.96       9.12  
   

 

 

                 

Unvested options at June 30, 2012

    103,993       11.54       9.28  
   

 

 

                 
Summary of changes in unvested restricted stock units
                 
    Number of RSUs     Weighted-average
grant
date fair value ($)
 

Unvested restricted stock units at March 31, 2012

    1,542,675       2.95  

Granted(1)

    54,000       0.82  

Vested

    (118,862     11.45  

Cancelled

    (10,280     12.17  
   

 

 

         

Balance unvested at June 30, 2012

    1,467,533       2.12  
   

 

 

         

 

 

(1) 34,000 of these restricted stock units vest and convert into shares of our common stock after one year from the date of grant. 20,000 of these restricted stock units will vest and convert into shares of our common stock over a four year period from the date of grant; one-fourth of the award will vest on each grant date anniversary following the grant.
Summary of changes in Stock appreciation rights
         
    Number of SARs  

Outstanding at March 31, 2012

    115,187  

Granted

    —    

Exercised

    —    

Forfeited and expired

    —    
   

 

 

 

Outstanding SARs at June 30, 2012

    115,187  
   

 

 

 

SARs exercisable at June 30, 2012

    115,187