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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2012
Stock-Based Compensation [Abstract]  
Stock-based compensation expense
                                 
    Three months ended
September 30,		     Nine months ended
September 30,		  
    2012     2011     2012     2011  

Research and development expense

   $ 314,393     $ 343,845     $ 966,570     $ 1,304,846  

Selling, general and administrative expense

     452,760       320,539       1,260,574       1,308,265  
   

 

 

    

 

 

    

 

 

    

 

 

  

Total employee stock-based compensation

   $ 767,153     $ 664,384     $ 2,227,144     $ 2,613,111  
   

 

 

    

 

 

    

 

 

    

 

 

  

Effect on basic and diluted net loss per share

   $ (0.03 )    $ (0.05 )    $ (0.09 )    $ (0.19 ) 
   

 

 

    

 

 

    

 

 

    

 

 

  
Stock option activity
                 
    Number of options     Weighted-average
exercise price ($) per share		  

Balance at June 30, 2012

     854,958       20.26  

Granted

     —         —    

Exercised

     —         —    

Cancelled

     (380,041 )      21.93  
   

 

 

          

Outstanding options at September 30, 2012

     474,917       18.91  
   

 

 

          
Summary of changes in unvested options
                         
    Number of options     Weighted-average
exercise price ($) per share		     Weighted-average
grant
date fair value ($) per option		  

Unvested options at June 30, 2012

     103,993       11.54       9.28  

Granted

     —         —         —    

Vested

     (14,466 )      12.04       9.71  

Cancelled

     (11,778 )      14.29       11.83  
   

 

 

                  

Unvested options at September 30, 2012

     77,749       11.04       8.82  
   

 

 

                  
Summary of changes in unvested restricted stock units
                 
    Number of RSUs     Weighted-average
grant
date fair value ($) per RSU		  

Unvested restricted stock units at June 30, 2012

     1,467,533       2.12  

Granted(1)

     52,000       2.15  

Vested

     (3,333 )      12.59  

Cancelled

     —         —    
   

 

 

          

Balance unvested at September 30, 2012

     1,516,200       2.10  
   

 

 

          

 

(1) 20,000 of these restricted stock units vest and convert into shares of our common stock after one year from the date of grant. 32,000 of these restricted stock units will vest and convert into shares of our common stock over a four year period from the date of grant; one-fourth of the award will vest on each grant date anniversary following the grant.
Summary of changes in Stock appreciation rights
         
    Number of SARs  

Outstanding at June 30, 2012

     115,187  

Granted

     —    

Exercised

     —    

Forfeited and expired

     (4,594 )
   

 

 

  

Outstanding SARs at September 30, 2012

     110,593  
   

 

 

  

SARs exercisable at September 30, 2012

     110,593