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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2012
Income Taxes [Abstract] |
Loss before Income tax attributable to geographic location | Loss before income taxes is attributed to the following geographic locations for the years ended December 31,
|  | 2012 |  |  | 2011 |
United States |  | $ | 28,355,949 |  |  | $ | 19,677,292 |
Foreign |  |  | 133,103 |  |  |  | 1,651,244 |
Total loss before taxes |  | $ | 28,489,053 |  |  | $ | 21,328,536 |
Components of deferred tax assets and liabilities | Significant components of our deferred tax assets and liabilities at December 31 are as follows:
|  | 2012 |  |  | 2011 |
Deferred tax assets: |  |  |  |  |  |  |  |
Capitalized research and development costs |  | $ | 53,824,000 |  |  | $ | 53,565,000 |
Net operating losses |  |  | 53,687,000 |  |  |  | 53,065,000 |
Research and development credits |  |  | 7,777,000 |  |  |  | 8,038,000 |
Accrued wind down cost |  |  | 292,000 |  |  |  | 630,000 |
Stock-based compensation |  |  | 853,000 |  |  |  | 512,000 |
Capital loss carryover |  |  | 544,000 |  |  |  | 596,000 |
Fixed assets |  |  | 430,000 |  |  |  | 458,000 |
Other |  |  | 1,002,000 |  |  |  | 731,000 |
|  |  | 118,409,000 |  |  |  | 117,595,000 |
Valuation allowance |  |  | (118,045,000 | ) |  |  | (117,181,000 | )
Total deferred tax assets |  | $ | 364,000 |  |  | $ | 414,000 |
Deferred tax liability: |  |  |  |  |  |  |  |
Intangible assets |  |  | (364,000 | ) |  |  | (414,000 | )
Total deferred tax liability |  | $ | (364,000 | ) |  | $ | (414,000 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |
Reconciliation of federal income tax rate | The effective tax rate as a percentage of income before income taxes differs from the statutory federal income tax rate (when applied to income before income taxes) for the years ended December 31 as follows:
|  | 2012 |  |  | 2011 |  |  | 2010 |
Statutory federal income tax (benefit) rate |  |  | (34 | )% |  |  | (34 | )% |  |  | (34 | )%
State income tax (benefit) rate |  |  | (3.3 | ) |  |  | (3.4 | ) |  |  | (3.6 | )
Increase resulting from: |  |  |  |  |  |  |  |  |  |  |  |
Expenses not deductible for taxes |  |  | 8.8 |  |  |  | (6.7 | ) |  |  | (0.4 | )
Increase in valuation allowance |  |  | 3.7 |  |  |  | 32.8 |  |  |  | 36.8 |
Change in state deferred tax rate |  |  | 17.7 |  |  |  | 0 |  |  |  | 0 |
Change in foreign deferred tax rate |  |  | 1.8 |  |  |  | 0 |  |  |  | 0 |
Expiration of tax attributes |  |  | 5.3 |  |  |  | 11.3 |  |  |  | 1.2 |
Effective tax (benefit) rate |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %

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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 + Details
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