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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2012
Stock-Based Compensation [Abstract] |
Stock-based compensation expense | Our stock-based compensation expense for the last three fiscal years was as follows:
|  | 2012 |  |  | 2011 |  |  | 2010 |
Research and development expense |  | $ | 1,280,298 |  |  | $ | 1,680,431 |  |  | $ | 2,034,007 |
General and administrative expense |  |  | 1,597,836 |  |  |  | 1,580,506 |  |  |  | 1,895,627 |
Total stock-based compensation expense and effect on net loss |  | $ | 2,878,134 |  |  | $ | 3,260,937 |  |  | $ | 3,929,634 |
Schedule of Fair Value Option Award, Assumptions | The weighted-average assumptions used for the last three fiscal years are as follows:
|  | 2012 |  |  | 2011 |  |  | 2010 |
Expected term (years)(1) |  |  | 6.4 |  |  |  | 7.4 |  |  |  | 7.2 |
Risk-free interest rate(2) |  |  | 1.4 | % |  |  | 2.7 | % |  |  | 2.9 | %
Expected volatility(3) |  |  | 78.4 | % |  |  | 79.7 | % |  |  | 88.4 | %
Expected dividend yield(4) |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
(1) | The expected term represents the period during which our stock-based awards are expected to be outstanding. We estimated this amount based on historical experience of similar awards, giving consideration to the contractual terms of the awards, vesting requirements, and expectation of future employee behavior, including post-vesting terminations.
(2) | The risk-free interest rate is based on U.S. Treasury debt securities with maturities close to the expected term of the option as of the date of grant.
(3) | Expected volatility is based on historical volatility over the most recent historical period equal to the length of the expected term of the option as of the date of grant.
(4) | We have neither declared nor paid dividends on any share of common stock and we do not expect to do so in the foreseeable future.
Stock option activity | A summary of our stock option activity and related information for the last three fiscal years is as follows:
|  | Outstanding Options |
|  | Number of Shares |  |  | Weighted- Average Exercise Price |  |  | Weighted-Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value(1) |
Balance at December 31, 2009 |  |  | 926,081 |  |  | $ | 22.80 |  |  |  | 6.2 |  |  | $ | 434,092 |
Granted |  |  | 257,850 |  |  | $ | 10.70 |  |  |  |  |  |  |  |  |
Exercised |  |  | (3,451 | ) |  | $ | 5.70 |  |  |  |  |  |  | $ | 13,418 |
Cancelled (forfeited and expired) |  |  | (82,239 | ) |  | $ | 20.50 |  |  |  |  |  |  |  |  |
Balance at December 31, 2010 |  |  | 1,098,241 |  |  | $ | 20.20 |  |  |  | 6.1 |  |  | $ | 398,219 |
Granted |  |  | 3,750 |  |  | $ | 7.30 |  |  |  |  |  |  |  |  |
Exercised |  |  | (1,692 | ) |  | $ | 1.41 |  |  |  |  |  |  | $ | 11,293 |
Cancelled (forfeited and expired) |  |  | (224,801 | ) |  | $ | 20.22 |  |  |  |  |  |  |  |  |
Balance at December 31, 2011 |  |  | 875,498 |  |  | $ | 20.13 |  |  |  | 5.5 |  |  | $ | — |
Granted |  |  | — |  |  |  |  |  |  |  |  |  |  |  |  |
Exercised |  |  | (3,629 | ) |  | $ | 1.00 |  |  |  |  |  |  | $ | 4,319 |
Cancelled (forfeited and expired) |  |  | (424,510 | ) |  | $ | 20.86 |  |  |  |  |  |  |  |  |
Balance at December 31, 2012 |  |  | 447,359 |  |  | $ | 19.59 |  |  |  | 5.1 |  |  | $ | 2,175 |
Exercisable at December 31, 2012 |  |  | 382,856 |  |  | $ | 21.06 |  |  |  | 4.8 |  |  | $ | 2,175 |
Vested and expected to vest(2) |  |  | 437,989 |  |  | $ | 19.77 |  |  |  | 5.1 |  |  | $ | 2,175 |
(1) | Aggregate intrinsic value represents the value of the closing price per share of our common stock on the last trading day of the fiscal period in excess of the exercise price multiplied by the number of options outstanding or exercisable, except for the “Exercised” line, which uses the closing price on the date exercised.
(2) | Number of shares includes options vested and those expected to vest net of estimated forfeitures.
Summary of changes in unvested options | The following is a summary of changes in unvested options:
Unvested Options |  | Number of Options |  |  | Weighted Average Grant Date Fair Value |
Unvested options at December 31, 2011 |  |  | 152,192 |  |  | $ | 9.43 |
Granted |  |  | — |  |  |  | — |
Vested |  |  | (63,911 | ) |  | $ | 9.81 |
Cancelled |  |  | (23,778 | ) |  | $ | 10.46 |
Unvested options at December 31, 2012 |  |  | 64,503 |  |  | $ | 8.67 |
Weighted average exercise price and remaining term information about significant option groups outstanding | The following table presents weighted average exercise price and remaining term information about significant option groups outstanding at December 31, 2012:
Options Outstanding at December 31, 2012 |
Range of Exercise Prices |  | Number Outstanding |  |  | Weighted Average Remaining Term (Yrs.) |  |  | Weighted Average Exercise Price |  |  | Aggregate Intrinsic Value at December 31, 2012 |
Less than $10.00 |  |  | 13,828 |  |  |  | 2.8 |  |  | $ | 3.57 |  |  | $ | 2,175 |
$10.00 - $19.99 |  |  | 256,482 |  |  |  | 6.3 |  |  | $ | 12.70 |  |  |  | — |
$20.00 - $29.99 |  |  | 119,249 |  |  |  | 4.0 |  |  | $ | 23.18 |  |  |  | — |
$30.00 - $39.99 |  |  | 21,800 |  |  |  | 3.0 |  |  | $ | 36.22 |  |  |  | — |
$40.00 - $49.99 |  |  | 5,500 |  |  |  | 2.7 |  |  | $ | 46.51 |  |  |  | — |
$50.00 - $59.99 |  |  | 30,500 |  |  |  | 2.7 |  |  | $ | 53.94 |  |  |  | — |
|  |  | 447,359 |  |  |  | 5.1 |  |  | $ | 19.59 |  |  | $ | 2,175 |
Vested Options Outstanding at December 31, 2012 |
Range of Exercise Prices |  | Number Outstanding |  |  | Weighted Average Exercise Price |
Less than $10.00 |  |  | 11,443 |  |  | $ | 2.77 |
$10.00 - $19.99 |  |  | 194,364 |  |  | $ | 13.25 |
$20.00 - $29.99 |  |  | 119,249 |  |  | $ | 23.18 |
$30.00 - $39.99 |  |  | 21,800 |  |  | $ | 36.22 |
$40.00 - $49.99 |  |  | 5,500 |  |  | $ | 46.51 |
$50.00 - $59.99 |  |  | 30,500 |  |  | $ | 53.94 |
|  |  | 382,856 |  |  | $ | 21.06 |
Summary of restricted stock unit activity | A summary of our restricted stock unit activity for the year ended December 31, 2012 is as follows:
|  | Number of RSUs |  |  | Weighted Average Grant Date Fair Value |
Outstanding at January 1, 2012 |  |  | 357,542 |  |  | $ | 10.56 |
Granted(1) |  |  | 1,358,000 |  |  | $ | 1.10 |
Vested and exercised |  |  | (171,062 | ) |  | $ | 11.30 |
Cancelled |  |  | (10,280 | ) |  | $ | 12.17 |
Outstanding at December 31, 2012 |  |  | 1,534,200 |  |  | $ | 2.10 |
(1) | 75,000 of these restricted stock units vest and convert into shares of our common stock after one year from the date of grant. 536,000 of these restricted stock units vest and convert into shares of our common stock over a three year period from the date of grant: one-third of the award will vest on each grant date anniversary following the grant. 747,000 of these restricted stock units vest and convert into shares of our common stock over a four year period from the date of grant: one-fourth of the award will vest on each grant date anniversary following the grant.
Summary of changes in outstanding SARs | The following is a summary of the changes in our outstanding SARs for the last three fiscal years:
|  | 2012 |  |  | 2011 |  |  | 2010 |
|  | Number |  |  | Weighted Average Exercise Price |  |  | Number |  |  | Weighted Average Exercise Price |  |  | Number |  |  | Weighted Average Exercise Price |
Outstanding at January 1, |  |  | 115,187 |  |  | $ | 20.00 |  |  |  | 135,409 |  |  | $ | 20.00 |  |  |  | 143,085 |  |  | $ | 20.00 |
Granted |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Exercised |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Forfeited |  |  | (4,594 | ) |  |  |  |  |  |  | (20,222 | ) |  |  |  |  |  |  | (7,676 | ) |  |  |  |
Outstanding at December 31, |  |  | 110,593 |  |  | $ | 20.00 |  |  |  | 115,187 |  |  | $ | 20.00 |  |  |  | 135,409 |  |  | $ | 20.00 |
Exercisable at December 31, |  |  | 110,593 |  |  | $ | 20.00 |  |  |  | 115,187 |  |  | $ | 20.00 |  |  |  | 135,409 |  |  | $ | 20.00 |

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