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Stock-Based Compensation (Details) (USD $)	12 Months Ended
Stock-Based Compensation (Details) (USD $)	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Stock-based compensation expense
Total stock-based compensation expense and effect on net loss	$ 2,878,134	$ 3,260,937	$ 3,929,634
Research and development expense [Member]
Stock-based compensation expense
Total stock-based compensation expense and effect on net loss	1,280,298	1,680,431	2,034,007
General and administrative expense [Member]
Stock-based compensation expense
Total stock-based compensation expense and effect on net loss	$ 1,597,836	$ 1,580,506	$ 1,895,627

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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