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Stock-Based Compensation (Tables)
 3 Months Ended
Mar. 31, 2013
Stock-Based Compensation [Abstract]  
Stock-based compensation expense

Our stock-based compensation expense for the first quarter ended March 31 was as follows:

 

                 
    Three months ended
March 31,		  
    2013     2012  

Research and development expense

   $ 343,711     $ 331,874  

Selling, general and administrative expense

     342,871       404,671  
   

 

 

    

 

 

  

Total employee stock-based compensation

   $ 686,582     $ 736,545  
   

 

 

    

 

 

  

Effect on basic and diluted net loss per share

   $ (0.02 )    $ (0.03 ) 
   

 

 

    

 

 

  
Stock option activity

A summary of our stock option activity for the three months ended March 31, 2013 is as follows:

 

                 
    Number of options     Weighted-average
exercise price ($) per share		  

Balance at December 31, 2012

     447,359       19.59  

Granted

     —         —    

Exercised

     —         —    

Cancelled

     (3,433 )      4.40  
   

 

 

          

Outstanding options at March 31, 2013

     443,926       19.70  
   

 

 

          
Summary of changes in unvested options

A summary of changes in unvested options for the three months ended March 31, 2013 is as follows:

 

                         
    Number of options     Weighted-average
exercise price ($) per share		     Weighted-average
grant
date fair value ($) per option		  

Unvested options at December 31, 2012

     64,503       10.86       8.67  

Granted

     —         —         —    

Vested

     (13,037 )      11.86       9.54  

Cancelled

     —         —         —    
   

 

 

                  

Unvested options at March 31, 2013

     51,466       10.61       8.45  
   

 

 

                  
Summary of restricted stock unit activity

A summary of our restricted stock units activity for the three months ended March 31, 2013 is as follows:

 

                 
    Number of RSUs     Weighted-average
grant
date fair value ($) per RSU		  

Outstanding at December 31, 2012

     1,534,200       2.10  

Granted(1)

     65,200       1.64  

Vested and exercised

     (362,418 )      1.06  

Cancelled

     —         —    
   

 

 

          

Outstanding RSUs at March 31, 2013

     1,236,982       2.38  
   

 

 

          

 

(1) 10,000 of these restricted stock units vest and convert into shares of our common stock after one year from the date of grant. 55,200 of these restricted stock units will vest and convert into shares of our common stock over a four year period from the date of grant; one-fourth of the award will vest on each grant date anniversary following the grant.
Summary of changes in SARs

A summary of the changes in SARs for the three months ended March 31, 2013 is as follows:

 

         
    Number of SARs  

Outstanding at December 31, 2012

     110,593  

Granted

     —    

Exercised

     —    

Forfeited and expired

     —    
   

 

 

  

Outstanding SARs at March 31, 2013

     110,593  
   

 

 

  

SARs exercisable at March 31, 2013

     110,593